ISSN:
1432-1912
Schlagwort(e):
Vernolepin
;
Antitumoral agents
;
Platelet aggregation
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Summary Vernolepin, a natural compound isolated from Vernonia amygdalina Del., shows platelet anti-aggregating properties. In this paper some of its pharmacological activities towards rabbit platelets are studied. Vernolepin has a “stabilizing” effect during freeze-thawing of platelets, it inhibits arachidonic acid, ADP and collagen-induced platelet aggregation and interferes with ATP-release. Electromicroscopy shows a protection of platelets by the drug against adhesion and a desaggregating effect. All these activities are time dependent; a steep dose response relationship is seen. A concentration of 1×10−5 g/ml seems to be optimal.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00498859
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