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  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    BBA - Biochimica et Biophysica Acta 3 (1949), S. 371-377 
    ISSN: 0006-3002
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Cancer immunology immunotherapy 1 (1976), S. 109-112 
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Patients with bad prognosis malignant lymphomas were treated by a combination of radiotherapy and polychemotherapy. After complete remission they were randomized: one group was treated by BCG in dermic scarification, the other one was not treated. The results do not ascertain BCG efficiency but justify the intensive reductive treatment.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Cancer immunology immunotherapy 3 (1977), S. 57-60 
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effectiveness of a nonspecific immunostimulation in related human or animal diseases incited us to do a study of nonspecific immunotherapy by BCG in Hodgkin's disease, and then in other malignant lymphomas. Seventy patients, each one fulfilling at least 2 criteria of poor prognosis, were initially put in complete remission by a combination of radio-chemotherapy, followed by a reinforcing chemotherapy. These patients were then randomized into two groups. The first group received no further treatment; the second received BCG in weekly cutaneous scarifications. Eight patients were excluded from the study. The rate of relapses is significantly lower in the treated group. The results are discussed. Other therapeutic studies are necessary to fix the indications and modalities of this immunotherapy.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 80 (1973), S. 179-188 
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Les auteurs analysent 124 cures de chimiothérapie associant vinblastine, procarbazine, cyclophosphamide et méthyl-prednisolone réalisées chez 90 malades atteints de maladie de Hodgkin. Ce traitement, appliqué à des malades hospitalisés, dure en principe trois semaines. L'intolérance, surtout hématologique (leucocytose inférieure à 2000μl) a conduit à abréger la cure dans près de la moitié des cas, mais, rapidement réversible, elle n'a gêné la réalisation d'une irradiation ultérieure que dans deux cas sur 81. Pour 101 cures interprétables, on a observé 10 échecs non totaux, 88 rémissions partielles dont 32 inférieures à 50% et 56 supérieures à 50% et 3 rémissions complètes. Un seul échec a été enregistré chez les 51 malades vierges de traitement. La place de ce traitement dans la stratégie du traitement de la maladie de Hodgkin est discutée et son intérêt souligné en tant que moyen pratique et efficace.
    Notes: Summary Ninety patients with Hodgkin's disease have received 124 courses of chemotherapy with vinblastine, procarbazine, cyclophosphamide and methyl-prednisolone. The treatment is given during a period of 2–3 weeks to hospitalized patients. The main toxicity is haematological and the course is stopped when the leucocytosis is to 2000μl or less. This chemotherapy has allowed a subsequent irradiation in all but 2 among 81 cases. For 101 evaluable courses there were 10 incomplete failures, 32 remissions of less than 50%, 56 remissions of more than 50% and 3 complete remissions. There was only one failure among 51 patients without previous treatment. The place of this chemotherapy in the therapeutic strategy of Hodgkin's disease is discussed.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1573-7217
    Keywords: adjuvant chemotherapy ; breast cancer ; CMF ; randomized trial ; steroid receptors ; tamoxifen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The purpose of a randomized trial achieved in a single centre (Fondation Bergonié, Bordeaux, France) was to compare chemotherapy alone (intravenous CMF) versus chemotherapy and hormonotherapy (CMF plus tamoxifen — 30 mg per day during 2 years), for patients with stage II breast carcinoma and positive values of estrogen and/or progesterone receptor (EPR) (〉10 and 〉15 fmoles mg protein−1 respectively). Three hundred and thirty four women treated by surgery ± radiotherapy are included in this trial from 06.01.81 to 12.31.84. No patient is lost for follow-up. Eight are excluded. Three hundred and twenty six patients are evaluable with a 38 month median follow-up. For EPR assay, the dextran charcoal micromethod was used in the same centre. The two groups are identical as far as age, hormonal status, TNM, EPR values, and histological features are concerned. Analysis of results shows a significant improvement of relapse free survival (p = 0.018) and also overall survival (p = 0.04) for the CMF + tamoxifen group.
    Type of Medium: Electronic Resource
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