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  • 1
    ISSN: 1432-1106
    Keywords: Harmaline tremor ; Cerebellum ; Inferior olive ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Purkinje cells were recorded extracellularly and mapped in the cerebellar cortex of the rat under tremogenic doses of harmaline. Four différent types of responses were encountered, of which two were considered as being responsible for the harmaline tremor. The latter had a regular firing pattern of complex spikes at 5 to 10 Hz and were mostly found in the vermis. Their number decreased in the more lateral region of the cerebellar cortex until they eventually disappeared. Horseradish peroxidase was injected into all the areas of the cerebellar cortex containing Purkinje cells with harmaline-induced activity. Labeled neurons were in all cases traced to the medial accessory olive. The metabolic activity of the inferior olive under harmaline was measured with 2-deoxyglucose. Increased labeling was only found in the medial accessory olive. Such an increase was demonstrated as being due to a direct effect of the drug on the inferior olivary neurons, indicating that the medial accessory olive is responsible for the harmaline tremor in the rat. Our results point out that, in the rat, there is an inverse relationship between serotoninergic innervation of a region in the inferior olivary nucleus and that with harmaline sensitivity, therefore a serotoninergic mechanism hypothesis for the harmaline tremor needs further investigation.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0300-9084
    Keywords: maximum entropy method ; multidimensional NMR ; nuclear magnetic resonance ; protein ; protein structure
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Computational complexity 7 (1998), S. 174-191 
    ISSN: 1420-8954
    Keywords: Key words. self‐reducibility; self‐correction; coherence.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract. We study three types of self‐reducibility that are motivated by the theory of program verification. A set A is random‐self‐reducible if one can determine whether an input x is in A by making random queries to an A‐oracle. The distribution of each query may depend only on the length of x. A set B is self‐correctable over a distribution ${\cal D}$ if one can convert a program that is correct on most of the probability mass of ${\cal D}$ to a probabilistic program that is correct everywhere. A set C is coherent if one can determine whether an input x is in C by asking questions to an oracle for C–{x}.¶We first show that adaptive coherence is more powerful than nonadaptive coherence, even if the nonadaptive querier is nonuniform. Blum et al.(1993) showed that every random‐self‐reducible function is self‐correctable. It is unknown, however, whether self‐correctability implies random‐self‐reducibility. We show, assuming a reasonable complexity‐theoretic hypothesis, that certain hard, sparse, tally sets exist, and that there is a self‐correctable function which is not random‐self‐reducible. For easily samplable distributions, however, we show that constructing a self‐correctable function that is not random‐self‐reducible is as hard as proving that P is different from PP.
    Type of Medium: Electronic Resource
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