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  • 1
    Electronic Resource
    Electronic Resource
    Involvement of the β 2-integrin CD18 in apoptosis signal transduction in human neutrophils (2000)
    Springer
    Inflammation research 49 (2000), S. 452-459 
    Details
    ISSN: 1420-908X
    Keywords: Key words: Programmed cell death - Reactive oxygen species - Adhesion - Cytoskeleton - Tyrosine phosphorylation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: Objective and design: To examine the hypothesis that an accelerated rate of neutrophil apoptosis occurs following β 2-integrin activation, and further investigate the signal transduction pathways involved.¶Material: Human polymorphonuclear neutrophils.¶Treatment: Neutrophils were challenged with pansorbins coated with antibodies towards the β 2-integrin subunit CD18 in a proportion of 1:100 with or without the inhibitors diphenylene iodonium (10 M), cytochalasin B (5 μg/ml), genistein (10 nM), herbimycin A (10 M) and Z-VAD-FMK (10 μM).¶Methods: Measurement of phosphatidylserine exposure and DNA fragmentation in flow cytometry and assessment of H2O2-production through spectrofluorometry. The results were analysed using Mann Whitney U test and Kruskal Wallis.¶Results: Pansorbins coated with antibodies to CD18 induce apoptosis in neutrophils (p〈0.01), and activate the production of reactive oxygen species (p〈0.01). Pre-treatment with the inhibitors have no effect on anti-CD18 induced apoptosis.¶Conclusion: Anti-CD18 pansorbins induce apoptosis in neutrophils through an alternative pathway not involving reactive oxygen species and independent of tyrosine phosphorylation, cytoskeletal reorganisation and caspases.¶
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050616
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of environmental stress on tissue survival and neutrophil recruitment in surgical skin flaps in relation to plasma corticosterone levels in the rat (1997)
    Springer
    Inflammation research 46 (1997), S. 199-202 
    Details
    ISSN: 1420-908X
    Keywords: Key words: Glucocorticoids — Neutrophil leukocytes — Surgical flaps — Stress
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective: Because glucocorticoid treatment can improve the survival of surgical skin flaps, we examined the influence of environmental stress on skin flap survival in the rat.¶Material: Female Sprague-Dawley rats.¶Treatment: Dexamethasone (1 mg/kg i.p.).¶Methods: A standardized dorsal skin flap was raised and sutured back into position, and six days later the percentage of flap survival was assessed. Corticosterone in rat plasma was measured using radioimmuno assay, and skin flap myeloperoxidase accumulation (reflecting neutrophil recruitment) was determined spectrophotometrically.¶Results: Skin flap survival decreased gradually during a 10 day acclimatization period after transportation of the animals from the supplier, and plasma corticosterone levels were increased during the first 5 days of acclimatization compared to day 7 and 10. Dexamethasone treatment of rats accustomed to their new environment for 10 days increased flap survival to a level close to that observed in animals operated at day 1 after arrival. Flap surgery induced pronounced neutrophil recruitment into flap tissue, and this cell accumulation was greatly reduced in both the dexamethasone treated rats and in rats with elevated corticosterone levels.¶Conclusions: Skin flap survival in rats exposed to environmental stress may be significantly increased as compared to animals accustomed to their new environment for one week, possibly as a consequence of anti-inflammatory actions exerted by stress-induced elevations in plasma corticosterone. These findings emphasize the importance of strictly controlling environmental stress factors in studies of inflammation and tissue damage after surgical skin trauma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050173
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  • 3
    Electronic Resource
    Electronic Resource
    Islet amyloid polypeptide: demonstration of mRNA in human pancreatic islets by in situ hybridization in islets with and without amyloid deposits (1993)
    Springer
    Diabetologia 36 (1993), S. 323-328 
    Details
    ISSN: 1432-0428
    Keywords: Islet amyloid polypeptide ; deposits ; fibrils ; in situ hybridization ; expression ; immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Islet amyloid polypeptide which is normally coexpressed with insulin in beta cells, forms amyloid deposits especially in islets of Type 2 (non-insulin-dependent) diabetic subjects. Occurrence of islet amyloid is paradoxically associated with loss of islet amyloid polypeptide immunoreactivity in beta cells. The present study was undertaken to examine whether the islet amyloid polypeptide gene is expressed in islets with decreased islet amyloid polypeptide immunoreactivity. Pancreatic tissue from 14 patients, 7 with Type 2 diabetes and 7 non-diabetic, were obtained at autopsy or surgery and studied for islet amyloid polypeptide expression by in situ hybridization and for presence of insulin and islet amyloid polypeptide by immunohistochemistry. Six of the specimens from the diabetic and three of those from the non-diabetic patients had varying degrees of islet amyloid polypeptide-derived islet amyloid. Amyloid deposits were associated with decreased numbers of beta cells with islet amyloid polypeptide immunoreactivity despite an apparent normal frequency of insulin-containing cells. This discrepancy might reflect an alteration in islet amyloid polypeptide production or processing at a transcriptional or post-transcriptional level. In contrast to the varying immunohistochemical patterns, islets of all categories showed strong labelling using an islet amyloid polypeptide probe for in situ hybridization. It is concluded that islet amyloid polypeptide production is not altered at the transcriptional level. The following possibilities remain: (1) islet amyloid polypeptide production may be altered at a post-transcriptional level or (2) that islet amyloid polypeptide production is normal but the reduced immunoreactivity of the cells reflects a reduced storage of IAPP in secretory granules. We favour the second possibility since islet amyloid deposition is incompatible with reduced islet amyloid polypeptide synthesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400235
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  • 4
    Electronic Resource
    Electronic Resource
    Nonlinear interaction between acoustic gravity waves (1996)
    Springer
    Annales geophysicae 14 (1996), S. 304-308 
    Details
    ISSN: 0992-7689
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract The resonant interaction between three acoustic gravity waves is considered. We improve on the results of previous authors and write the new coupling coefficients in a symmetric form. Particular attention is paid to the low-frequency limit.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s00585-996-0304-3
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  • 5
    Electronic Resource
    Electronic Resource
    A basis set study for the calculation of electronic excitations using Monte Carlo configuration interaction (2001)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 114 (2001), S. 15-22 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: A systematic study of basis sets and many-body correlations for the treatment of electronic excitations is presented. Particular emphasis is placed on the highly accurate treatment of transition energies within a computationally tractable scheme. All calculations have been performed using the Monte Carlo configuration interaction method and correlation-consistent basis sets augmented by diffuse functions constructed for the description of anions, and with the inclusion of additional Rydberg functions. The importance of a balanced description of the excited states and the ground state has been emphasized and the resulting electronic transitions have been compared with experimental values. We have found that the aug-cc-pVTZ basis set further augmented with Rydberg functions constitutes a good choice of basis set for which we report electronic excitations in excellent agreement with experiment. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1328394
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  • 6
    Electronic Resource
    Electronic Resource
    Phosphorous trapped within buckminsterfullerene (2002)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 116 (2002), S. 7849-7854 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Under normal circumstances, when covalent molecules form, electrons are exchanged between atoms to form bonds. However, experiment and theoretical computations reveal exactly the opposite effect for the formation of group V elements nitrogen and phosphorous encapsulated within a buckminsterfullerene molecule. The C60 carbon cage remains intact upon encapsulation of the atom, whereas the electronic charge cloud of the N or P atom contracts. We have studied the chemical, spin, and thermodynamic properties of endohedral phosphorous (P@C60) and have compared our results with earlier findings for N@C60. From a combined experimental and theoretical vantage, we are able to elucidate a model for the interaction between the trapped group V atom and the fullerene cage. A picture emerges for the electronic structure of these complexes, whereby an atom is trapped within a fullerene, and interacts weakly with the molecular orbitals of the C60 cage. © 2002 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1468643
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  • 7
    Electronic Resource
    Electronic Resource
    The use of prediction models for eliminating effects due to regression-to-the-mean in road accident data
    Amsterdam : Elsevier
    Accident Analysis and Prevention 20 (1988), S. 299-310 
    Details
    ISSN: 0001-4575
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Architecture, Civil Engineering, Surveying , Psychology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0001-4575(88)90057-7
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  • 8
    Electronic Resource
    Electronic Resource
    Models for predicting accidents at junctions where pedestrians and cyclists are involved. How well do they fit?
    Amsterdam : Elsevier
    Accident Analysis and Prevention 25 (1993), S. 499-509 
    Details
    ISSN: 0001-4575
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Architecture, Civil Engineering, Surveying , Psychology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0001-4575(93)90001-D
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  • 9
    Electronic Resource
    Electronic Resource
    Three-wave interaction in the presence of an oscillating electric field
    Amsterdam : Elsevier
    Physics Letters A 76 (1980), S. 396-398 
    Details
    ISSN: 0375-9601
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0375-9601(80)90742-2
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  • 10
    Electronic Resource
    Electronic Resource
    Isolation and partial characterization of a low molecular weight trypsin inhibitor from human urine
    Amsterdam : Elsevier
    BBA - Protein Structure 667 (1981), S. 303-308 
    Details
    ISSN: 0005-2795
    Keywords: (Human urine) ; N-terminal sequence ; Trypsin inhbitor
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0005-2795(81)90196-3
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