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  • 1
    Digitale Medien
    Digitale Medien
    Growth hormone and renal function (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Nephrology 3 (1997), S. 0 
    Details
    ISSN: 1440-1797
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Summary: Recombinant human growth hormone (rhGH) has been recognized to be beneficial for improving growth retardation in uraemic children. the potential effect of growth hormone (GH) on renal haemodynamics results in an increase in glomerular filtration rate and renal plasma flow. However, in GH transgenic mice and uraemic rats treated with GH, GH has been reported to aggravate glomerular sclerosis and induce deterioration in renal function. Therefore, the potential of adverse effect of GH on deterioration in renal function has been of concern in uraemic children receiving rhGH. Growth hormone enhances protein anabolism and promotes a positive nitrogen balance. It is more likely that the anabolic effect of GH used at the conventional dose may reduce renal solute load and slow the progression of end-stage renal failure (ESRF) in rhGH-treated uraemic children. A low protein diet with adequate calories slows the deterioration of renal function in uraemic patients. the effects of GH on growth promotion, renal haemodynamics and protein anabolism are mainly mediated by insulin-like growth factor-I (IGF-I). Insulinlike growth factor-I enhances glomerular filtration rate and promotes glomerular hypertrophy, but IGF-I administration is unlikely to give rise to glomerular sclerosis. the efficacy and the safety of concomitant therapy of recombinant GH or IGF-I and low protein diet should therefore be considered in uraemic children.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1440-1797.1997.tb00248.x
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  • 2
    Digitale Medien
    Digitale Medien
    Vitamin D metabolites and growth hormone therapy in uraemic rats: the short-term effect on growth failure and hyperparathyroidism (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Nephrology 2 (1996), S. 0 
    Details
    ISSN: 1440-1797
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Summary: The aim of our study was to evaluate the effect of 1,25 dihydroxyvitamin D3 (D), 22-oxacalcitriol (O) or recombinant human growth hormone (GH) on growth failure and hyperparathyroidism in 5/6 nephrectomized uraemic (Ur) rats. Seven groups of rats were studied: (i) sham controls (SC; n=6); (ii) Ur controls (UrC;n=8); (iii) Ur treated either with D (UrD; n=7); (iv) O (UrO, n=8); (v) GH (UrGH; n=7); (vi) D+GH (UrDGH; n=9); or (vii) O+GH (UrOGH; n=7). For 14 days, D and O were administered intraperitoneally daily at 30 ng/kg per day and GH subcutaneously daily at 1.3 i.u./day. Four weeks after 5/6 nephrectomy, plasma creatinine (Cr), plasma and urine calcium (Ca), plasma phosphate (P), ratio of urine Ca/urine Cr, amino-terminal parathyroid hormone (PTH; pg/mL) and Ca/dry bone weight in the left femur (mg/g) were measured. Uraemic controls, UrD, UrO and UrDGH rats were lower in weight gain than SC rats over the study period, but linear growth was not retarded in any uraemic group. Plasma Cr was greatly increased in any Ur group as compared with SC group. Plasma Ca and P concentrations did not differ among each group. the ratio of urine Ca/urine Cr in UrD and UrDGH groups was higher than SC, UrCand UrGH groups. the use of Dor D+GH suppressed PTH, returning the level in these rats to the normal level of the SC rats, while the PTH concentrations in the UrO and UrOGH rats were less decreased. Bone Ca content was enhanced by D+GH and O+GH administration in comparison with UrC rats, but there was no difference in the bone Ca content between UrD and UrDGH rats, and between UrO and UrOGH rats. In conclusion, growth failure in weight was shown in uraemia, but linear growth was not retarded in any uraemic group. 1.25 dihydroxyvitamin D3 and D plus GH successfully suppressed secondary hyperparathyroidism. Further studies are needed in order to elucidate the interactions on bone between vitamin D rnctabolites and GH.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1440-1797.1996.tb00095.x
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  • 3
    Digitale Medien
    Digitale Medien
    Obstructive airway disease caused by Moraxella catarrhalis after renal transplantation (2000)
    Springer
    Pediatric nephrology 14 (2000), S. 707-709 
    Details
    ISSN: 1432-198X
    Schlagwort(e): Key words Biedl-Bardet syndrome ; Moraxella catarrhalis ; Pulmonary obstructive disease ; Renal transplantation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  We report a case of severe acute obstructive airway disease 2 months after renal transplantation in a 16-year-old patient with Biedl-Bardet syndrome who was transplanted for end-stage renal failure secondary to cystic kidney disease. Symptoms of severe obstructive airway disease developed 2 months after transplantation under immunosuppression with prednisone, azathioprine, and tacrolimus. The patient did not develop signs of infection; progressive shortness of breath remained the only symptom for several weeks. After extensive diagnostic evaluation, bronchoalveolar lavage revealed Moraxella catarrhalis as the single infectious agent. After 3 weeks of appropriate antibiotic therapy, symptoms of obstructive airway disease were completely relieved. This atypical presentation of Moraxella infection in an immunocompromised host represents a rare complication of renal transplantation, especially in young patients. Special aspects such as frequency, diagnosis, differential diagnosis, and management of this rare complication of renal transplantation in a pediatric patient are discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/PL00013421
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  • 4
    Digitale Medien
    Digitale Medien
    Therapeutics of X-linked hypophosphatemic rickets (1993)
    Springer
    Pediatric nephrology 7 (1993), S. 744-748 
    Details
    ISSN: 1432-198X
    Schlagwort(e): X-linked hypophosphatemic rickets ; Nephrocalcinosis ; Hypercalciuria ; Pregnancy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract X-linked hypophosphatemia, the most common form of familial rickets, is conventionally treated with 1,25-dihydroxyvitamin D3 (5–50 ng/kg per day) plus phosphate supplementation (70–100 mg/kg per day). However, nephrocalcinosis is noted in many children treated with this therapy. Whether to treat or not and whether such treatment should be continued into adulthood or in pregnancy are unsettled questions. This article reviews these controversies and provides current recommendations.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01213343
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  • 5
    Digitale Medien
    Digitale Medien
    Non-compliance following renal transplantation in children and adolescents (1998)
    Springer
    Pediatric nephrology 12 (1998), S. 703-708 
    Details
    ISSN: 1432-198X
    Schlagwort(e): Key words: Non-compliance ; Renal transplantation ; Communication
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract. Reported frequencies of non-compliance in children with end-stage renal disease range from 8% to 70% with a mean around 40%. Sequelae amount to momentous emotional and financial burdens, including the loss of 7% of transplanted organs. Reasons for non-compliance have too often been attributed selectively to the patients (e.g., emotional, mental, social, or communication problems). Compared with general compliance research, this selective attribution appears to be too simplistic. Selective attribution neglects the patients’ experiences within the context of disease and treatment and prevents open communication about non-compliance. Research on personal reasons for non-compliance is scarce. In psychological interviews, a third of our 85 patients with end-stage renal disease (34 boys, 51 girls, mean age 12.7 years, range 7.4–19.3 years) communicated psychologically meaningful reasons for non-compliance, frequently related to interrelational and systemic treatment conditions. Patients indirectly asked for more communication about their subjective reasons for non-compliance.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s004670050531
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  • 6
    Digitale Medien
    Digitale Medien
    Continuous arteriovenous haemofiltration in critically ill children (1994)
    Springer
    Pediatric nephrology 8 (1994), S. 334-337 
    Details
    ISSN: 1432-198X
    Schlagwort(e): Continuous arteriovenous haemofiltration ; Acute renal failure ; Cardiac surgery ; Liver failure
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We report 24 children with acute renal failure treated with continuous arteriovenous haemofiltration (CAVH) between 1987 and 1991. The median age was 2.9 years (range 3 days to 9 years). The main causes of the acute renal failure were: open heart surgery (n=11) and liver failure of different origins before and after liver transplantation (n=10). The indication for CAVH was oliguria or fluid overload in all children. The femoral vessels were used as vascular access in most instances. Different filters were used, depending on the size of the patient and an average ultrafiltration of 130±89 ml/h was achieved, which resulted in a fluid clearance of 4.0±2.6 ml/min per 1.73 m2. In 18 patients uraemia was adequately controlled. Nine children survived after recovery of their renal function; 15 (62.5%) died as a consequence of multiorgan failure. We conclude that CAVH is an effective method to support critically ill children with acute renal failure.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00866352
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  • 7
    Digitale Medien
    Digitale Medien
    One year's experience with recombinant erythropoietin in children undergoing continuous ambulatory or cycling peritoneal dialysis (1990)
    Springer
    Pediatric nephrology 4 (1990), S. 498-500 
    Details
    ISSN: 1432-198X
    Schlagwort(e): Recombinant human erythropoietin ; Continuous ambulatory peritoneal dialysis ; Continuous cycling peritoneal dialysis ; Renal anaemia
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Fourteen patients (aged 5.9–22.1 years) undergoing continuous ambulatory or cycling peritoneal dialysis were treated with recombinant human erythropoietin (rhEPO), which was given intravenously once a week at a dosage of 300 units/kg. The mean haematocrit level increased from 18.5% to 27.5% and the reticulocyte count from 19‰ to 62‰ within 1 month. After an average time of 3.1 months rhEPO dosage could be adjusted to 100 units/kg per week to keep the haematocrit level at 30%. Only 1 patient had an exacerbation of hypertension, which required a dosage reduction; other side-effects were not noted.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00869830
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  • 8
    Digitale Medien
    Digitale Medien
    Growth hormone resistance in uremia (1997)
    Springer
    Clinical and experimental nephrology 1 (1997), S. 179-186 
    Details
    ISSN: 1437-7799
    Schlagwort(e): uremia ; growth failure ; growth hormone ; growth hormone resistance ; insulin-like ; growth factor I ; growth hormone receptor mRNA
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Growth retardation is a major complication in children with uremia. Protein restriction, calorie deficit, metabolic acidosis, renal osteodystrophy, and endocrinologic disturbances contribute to the growth failure. The effect of these factors on growth retardation can be attenuated in part by therapy with vitamin D metabolites, adequate nutrition, alkalization, and dialysis. Linear growth in children with uremia is markedly retarded despite normal or increased levels of circulating serum growth hormone. An increased growth hormone level in children with uremia is due to normal growth hormone secretion from the pituitary gland and impaired growth hormone clearance in the kidney. However, the elevated growth hormone level does not lead to a commensurate rise in serum insulin-like growth factor I (IGF-I); the serum IGF-I level is decreased or normal in relation to the degree of renal failure. This discrepancy suggests growth hormone resistance in the liver in uremia. Recent molecular techniques open a new era in studying the gene expression for growth hormone or IGF-I. There is no doubt today that growth hormone treatment has the beneficial effect of growth promotion in children with uremia, which also suggests endogenous growth hormone resistance in target organs or target cells in uremia.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02480693
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  • 9
    Digitale Medien
    Digitale Medien
    Growth hormone aggravates glomerular sclerosis in the remnant kidney of 5/6 nephrectomized uremic rats (1997)
    Springer
    Clinical and experimental nephrology 1 (1997), S. 92-98 
    Details
    ISSN: 1437-7799
    Schlagwort(e): growth hormone ; insulin-like growth factor-I ; glomerular hypertrophy ; glomerular sclerosis ; uremia
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Background Our study evaluated the influence of short-term growth hormone treatment on the remnant kidney in 5/6 nephrectomized uremic rats Methods Twenty male Sprague-Dawley rats were divided into 4 groups: sham-operated control rats (SC, n=4); sham-operated rats treated with recombinant human growth hormone (SGH, n=4); uremic (5/6 nephrectomized) control rats (UrC, n=6); and uremic rats treated with recombinant human growth hormone (UrGH, n=6). Total food intake, food efficiency, average daily food intake per 100 g body weight, weight gain, increase in body length, creatinine clearance, and kidney weight per 100 g body weight were measured. Glomerular tuft area was determined, and the severity of glomerular sclerosis was scored. Insulin-like growth factor-I was localized in the kidneys by immunostaining. Results Weight gain, increase in body length, food efficiency, and food intake per unit body weight were greatest in the SGH group; in UrGH animals, food efficiency and food intake per unit body weight were significantly higher than those in UrC rats. Creatinine clearance in uremic rats was significantly reduced compared with that in sham-operated animals. There was no difference in the ratio of kidney weight to body weight among the groups. The average glomerular area was greatest, and the glomerular sclerosis index was highest, in the UrGH group. No insulin-like growth factor-I could be identified in the glomeruli. Conclusions Growth-hormone treatment augmented daily food intake, and the more rapid progression to glomerular sclerosis in hormone-treated uremic rats is probably due mainly to increased daily protein intake.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02479907
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