ISSN:
1420-908X
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The platelet-activating factor, of PAF-acether, is a phospholipid derivative that is a potent aggregating agent. It is formed by platelets themselves and also by basophils, neutrophils, monocytes and macrophages including alveolar macrophages. A role for PAF-acether during inflammation is envisaged since its intravenous administration induces hypotension, thrombocytopenia and bronchoconstriction in anaesthetized guinea-pigs. It is hypothesized that platelets, which contain and synthetize many pro-inflammatory substances, play a primary role in some pathological states.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02024151
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