ISSN:
1432-2072
Keywords:
l-Fenfluramine
;
Haloperidol
;
qEEG
;
Rats
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract EEG effects of l-fenfluramine (l-F) (2.5, 5 and 10 mg/kg) and haloperidol (0.1, 0.25 and 0.5 mg/kg) were studied in 20 adult rats. The EEG signals of two prefrontal (A=+4, L=2.5) and two sensorimotor (A=-4, L=4) transcortical electrodes were analyzed in each rat during three 60-min periods, 1, 3 and 5 h after the intraperitoneal (IP) administration of the drugs. In the prefrontal cortex haloperidol induced a decreased power for the 1–3 Hz components and an increase in power for frequencies higher than 8 Hz, with a maximum around 13 Hz. These effects were already observed after 0.1 mg/kg. In this cortical area l-F administration was essentially associated with a decrease of power maximum for 3–8 Hz, an increased power for the 10–19 Hz band being present only after 10 mg/kg. In the sensorimotor cortex haloperidol appeared less potent than in the prefrontal site; a significant power increase for the frequencies higher than 8 Hz was only observed with 0.5 mg/kg. On the contrary, l-F appeared more effective in this area, its action being characterized by a decreased power from 2–8 Hz and a power increase already significant with 2.5 mg/kg for the frequencies higher than 10 Hz, with a maximum lying around 15 Hz. These results suggest that haloperidol induced cortical sedation (increased power) on the two recording sites. l-F also induced a net cortical sedation in sensorimotor cortex but up to 5 mg/kg acted in the opposite direction on the prefrontal cortex. These results could be related to the different changes induced by the two drugs on the dopaminergic neurotransmitter system.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00442019
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