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Digitale Medien

Asymmetric cerebral blood flow patterns in migraine (1987)

Levine, Steven R ; Welch, K M A ; Ewing, James R ; [weitere]

USA/Oxford, UK : Blackwell Science Ltd

Cephalalgia 7 (1987), S. 0

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ISSN: 1468-2982

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: Although asymmetric EEG abnormalities have been reported during the headache-free period in migraineurs, asymmetries of regional cerebral blood flow (rCBF) have not been studied. Headache-free rCBF values measured by 133Xe inhalation were lower in migraineurs than in controls. Interhemispheric CBF and regional (anterior versus posterior) CBF did not differ between the groups. When a novel scoring system was used to obtain a mean asymmetry index (MAI), the MAI of the classiccomplicated group was significantly higher than that of the controls but not significantly different from that of the common migraine group. These data suggest that in the headache-free interval rCBF asymmetries, variable in location, exist in classiccomplicated migraineurs. These rCBF changes may be related to the cause or the effect of the focal neurologic dysfunction that occurs during an attack in these patients

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1046/j.1468-2982.1987.0704245.x

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Digitale Medien

Migraine and the lupus anticoagulant (1987)

Levine, Steven R ; Joseph, Rajiv ; D'Andrea, Giovanni ; [weitere]

USA/Oxford, UK : Blackwell Science Ltd

Cephalalgia 7 (1987), S. 0

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ISSN: 1468-2982

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: Lupus anticoagulants (LA) are antiphospholipid serum immunoglobulins generally associated with autoimmune conditions, especially systemic lupus erythematosus (SLE). They have recently been linked to thrombotic events, including stroke. A possible association of migraine with LA is now forwarded with the presentation of two cases and a literature review. Our two patients, both in their forties, had migrainous phenomena without SLE or thrombotic events. Eight other cases were found in the literature, suggesting more than a chance association. Relevance to migraine pathophysiology is discussed and may come from the ability of the LA to alter prostaglandins and platelet activity and to interact with neuronal phospholipids. Further, larger studies are needed to support this association.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1046/j.1468-2982.1987.0702093.x

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Digitale Medien

Brain pH in migraine: An in vivo phosphorus-31 magnetic resonance spectroscopy study (1988)

Welch, K M A ; Levine, Steven R ; D'Andrea, Giovanni ; [weitere]

USA/Oxford, UK : Blackwell Science Ltd

Cephalalgia 8 (1988), S. 0

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Details

ISSN: 1468-2982

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: The intracellular pH (pHi ) of cerebral cortex was measured in migraine patients by use of in vivo phosphorus-31 NMR spectroscopy. No changes in pHi were measured during a migraine attack. The long-standing concept that the headache of migraine is due to cerebral vaso-dilatation induced by prodromal vasospasm-induced ischemic acidosis is not substantiated.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1046/j.1468-2982.1988.0804273.x

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