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  • 1
    Digitale Medien
    Digitale Medien
    TOXICOLOGICAL BASES FOR THE SETTING OF HEALTH-RELATED AIR POLLUTION STANDARDS (2000)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Public Health 21 (2000), S. 309-333 
    Details
    ISSN: 0163-7525
    Quelle: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Thema: Medizin
    Notizen: Abstract The development of air pollution standards ideally involves the integration of data from the disciplines of epidemiology, controlled clinical studies, and animal toxicology. Epidemiological studies show statistical associations between health outcomes and exposure; they cannot establish a definite cause-effect relationship. The utility of toxicological studies is to establish this relationship. Recently, there was simultaneous promulgation of a new National Ambient Air Quality Standard (NAAQS) for particulate matter 〈2.5 mum in aerodynamic diameter (PM2.5) and a revised NAAQS for ozone (O3). The O3 NAAQS was based, in part, on a sound foundation of toxicological data from controlled exposure studies in humans and animals. It also relied on epidemiological studies of hospital admissions for respiratory diseases. Such studies also served as important bases for the new PM2.5 NAAQS. However, the most influential bases for the PM NAAQS were the numerous and generally consistent epidemiological studies that associated exposure with premature mortality in susceptible subpopulations and the inability of numerous hypothesized confounding factors to negate the associations. Using ozone and PM as examples, this paper discusses the scientific basis for NAAQS promulgations in situations in which the underlying database differed greatly in the extent of toxicological support.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1146/annurev.publhealth.21.1.309
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  • 2
    Digitale Medien
    Digitale Medien
    Effects of Ozone on Respiratory Function and Structure (1989)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Public Health 10 (1989), S. 49-67 
    Details
    ISSN: 0163-7525
    Quelle: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1146/annurev.pu.10.050189.000405
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  • 3
    Digitale Medien
    Digitale Medien
    The use of ketamine in civilian and military surgery (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 44 (1989), S. 0 
    Details
    ISSN: 1365-2044
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2044.1989.tb11423.x
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  • 4
    Digitale Medien
    Digitale Medien
    FACTORS INFLUENCING DUST RETENTION IN THE PULMONARY PARENCHYMA (1972)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 200 (1972), S. 0 
    Details
    ISSN: 1749-6632
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Allgemeine Naturwissenschaft
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1749-6632.1972.tb40176.x
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  • 5
    Digitale Medien
    Digitale Medien
    Factors affecting distribution of airflow in a human tracheobronchial cast
    Amsterdam : Elsevier
    Respiration Physiology 93 (1993), S. 261-278 
    Details
    ISSN: 0034-5687
    Schlagwort(e): Airflow, human airways, cast ; Airways, cast ; Distribution, airflow airways
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://linkinghub.elsevier.com/retrieve/pii/0034-5687(93)90073-J
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  • 6
    Digitale Medien
    Digitale Medien
    Susceptibility to amiodarone-induced pulmonary toxicity: Relationship to the uptake of amiodarone by isolated lung cells (1996)
    Springer
    Lung 174 (1996), S. 31-41 
    Details
    ISSN: 1432-1750
    Schlagwort(e): Amiodarone ; Pulmonary uptake ; Pulmonary toxicity
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract In previous studies, we showed that Fischer rats fed 175 mg/kg of amiodarone accumulated large amounts of drug and metabolite in the lung and developed pulmonary toxicity, whereas Wistar rats fed the same drug dose had significantly less amiodarone in the lung and did not develop pulmonary inflammation. The present study was designed to determine whether this difference in susceptibility between the strains was related to differences in uptake of amiodarone by lung cells. We found that isolated mixed lung cells of Fischer rats sequester significantly more drug than cells from Wistar rats. This difference in uptake cannot be due to drug metabolism because the lung is not capable of metabolizing amiodarone. We also found that the alveolar macrophage is one of the cell types in the mixed cell population that is partially responsible for the difference in drug uptake and that fibroblasts and type II pneumocytes are not involved. In addition, despite the fact that there was no difference in drug uptake, we found that fibroblasts isolated from Fischer rats were more susceptible to amiodarone-induced cytotoxicity than were Wistar fibroblasts. We conclude that genetic differences in lung drug sequestration and possibly the sensitivity to cytotoxicity may explain differences in susceptibility to amiodarone-induced pulmonary toxicity.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00167949
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  • 7
    Digitale Medien
    Digitale Medien
    Primärer Formwandel der Thrombozyten in vitro (1978)
    Springer
    Annals of hematology 37 (1978), S. 327-339 
    Details
    ISSN: 1432-0584
    Schlagwort(e): Platelet shape change ; Inhibition of platelet shape change ; Thrombozyten-Formwandel ; Hemmung des Thrombozyten ; Formwandels
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Bei der Untersuchung mit dem Interferenz-Kontrast-Mikroskop zeigen die Thrombozyten nach der Blutentnahme im Zitrat-Blut, -Plasma, Heparin- und EDTA-Blut innerhalb von 30–60′ charakteristische, quantifizierbare FormverÄnderungen: Quellung, Bildung von Pseudopodien, kleinsten Vesikeln und Unebenheiten an der PlÄttchenoberflÄche. Dieser „Formwandel“ wird durch niedrige Inkubationstemperaturen (4
    Notizen: Summary Studies with interference contrast microscopy reveal that platelets undergo a typical shape change within 30–60′ after venepuncture, i.e. swelling, formation of large tentacles, tiny protrusions and vesicles at the platelet surface. This “shape change” can be observed in citrated blood and PRP, heparinized blood and EDTA-blood as well. It is enhanced by low incubation temperatures (4
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01007868
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