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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 54 (1998), S. 815-815 
    ISSN: 1432-1041
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 147 (2002), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 146 (2002), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Background The long-term prognosis of patients treated for erythema migrans has only rarely been assessed. Objectives To evaluate the clinical characteristics and long-term prognosis of patients treated for erythema migrans in the region of Alsace, France. Methods In a prospective study, 56 consecutive patients presenting with erythema migrans at the Strasbourg University Hospital between 1995 and 1999 were examined and a Borrelia burgdorferi enzyme immunoassay was performed. Patients were treated with tetracyclines or amoxycillin. Patients were re-examined 6 weeks later and a telephone interview was performed in summer 2000 to evaluate the long-term outcome. Results There were 25 women and 31 men of mean age 49 years presenting with single (n = 54) or multiple (n = 2) erythema migrans lesions. At the time of diagnosis, 30% of the patients had systemic signs, myalgias or arthralgias and only 36% of 50 patients were seroreactive against B. burgdorferi. None of the 51 patients evaluated at 6 weeks and none of the 37 patients interviewed after a median delay of 3 years had developed complications attributable to Lyme borreliosis. Conclusions The prognosis of patients treated for Lyme borreliosis in this part of France is excellent. Therefore, a complete clinical examination is sufficient as an initial evaluation and long-term follow-up is not necessary.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The Schnitzler syndrome is the association of chronic urticaria, intermittent fever, osteosclerotic bone lesions and a monoclonal IgM gammopathy. It is not yet firmly established whether the monoclonal immunoglobulin component plays a part in the pathophysiology of the urticarial lesions. Immunoblotting on epidermal and dermal human skin extracts as well as immunoelectron microscopic (IEM) studies on Lowicryl K4M-embedded skin sections were performed in three patients with the Schnitzler syndrome. Western blotting on epidermal extracts showed the presence of IgM-κ antiskin autoantibodies in two patients. These antibodies displayed the same isotype as the monoclonal components and recognized a 280–290-kDa antigen in one patient and a 200-kDa antigen in the other patient. IEM studies showed sparse IgM deposits in the epidermis, around the keratinocytes, near the desmosomes in one patient and dense deposits below the lamina densa, in the region of the anchoring fibrils, in another patient. Antiskin IgM autoantibodies of the same isotype as their monoclonal gammopathies can be present in the serum of some patients with the Schnitzler syndrome. These IgM antibodies seem to deposit in vivo in the epidermis and at the dermal–epidermal junction, in the region of the anchoring fibrils. These findings suggest that the monoclonal gammopathy plays a part in the pathophysiology of the skin rash. They also suggest patient heterogeneity both in the skin antigens that are recognized as well as in their localization.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    New York, NY : American Institute of Physics (AIP)
    Physics of Fluids 5 (1993), S. 1746-1753 
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: This study provides an analytic solution to the general problem of mode conversion in an unmagnetized plasma. Specifically, an electromagnetic wave of frequency ω propagating through a plasma with a parabolic density profile of scale length Lp is examined. The mode conversion points are located a distance Δ0 from the peak of the profile, where the electron plasma frequency ωp(z) matches the wave frequency ω. The corresponding reflection, transmission, and mode conversion coefficients are expressed analytically in terms of parabolic cylinder functions for all values of Δ0. The method of solution is based on a source approximation technique that is valid when the electromagnetic and electrostatic scale lengths are well separated. For large Δ0, i.e., (cLp/ω)1/2(very-much-less-than)Δ0〈Lp, the appropriately scaled result [D. E. Hinkel-Lipsker et al., Phys. Fluids B 4, 559 (1992)] for a linear density profile is recovered as the parabolic cylinder functions asymptotically become Airy functions. When Δ0→0, the special case of conversion at the peak of the profile [D. E. Hinkel-Lipsker et al., Phys. Fluids B 4, 1772 (1992)] is obtained.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    New York, NY : American Institute of Physics (AIP)
    Physics of Fluids 4 (1992), S. 1772-1787 
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: For mode conversion in an unmagnetized plasma with a parabolic density profile of scale length L, analytic expressions, in terms of parabolic cylinder functions, for the energy flux coefficients (reflection, transmission, and mode conversion) and the fields for both the "direct'' problem (incident electromagnetic wave converting to a Langmuir wave) and the "inverse'' problem (incident Langmuir wave converting to an electromagnetic wave) are derived for the case where the incident wave frequency ω matches the electron plasma frequency ωp at the peak of the density profile. The mode conversion coefficient for the direct problem is equal in magnitude to that of the inverse problem, and the corresponding reflection and transmission coefficients satisfy energy conservation. In contrast to the linear profile problem, the conversion efficiency depends explicitly on the value of the collision frequency (in the cold, collisional limit) or electron temperature (in the warm, collisionless limit), but a transformation of parameters relates the results for these two limits.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    New York, NY : American Institute of Physics (AIP)
    Physics of Fluids 4 (1992), S. 559-575 
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The transformation of electromagnetic waves into Langmuir oscillations (and vice versa) is explicitly examined in the vicinity where the wave frequency matches the electron plasma frequency in an inhomogeneous plasma. For an unmagnetized plasma with a linear density profile of scale length L, closed-form, analytic expressions are derived, in terms of Airy functions, for the reflection and mode conversion coefficients of Langmuir and electromagnetic waves utilizing a source approximation that is valid when the electromagnetic field scale length is large compared to that of the electrostatic field. The technique developed to determine the energy flux coefficients and the fields is general enough to apply to a plasma with a profile other than a linear one, and should prove useful in other problems where a scale length separation is valid. The reflection coefficient for the "direct'' problem (incident electromagnetic wave) is equal in magnitude to that of the "inverse'' problem (incident electrostatic wave) and the corresponding mode conversion coefficients satisfy energy conservation. The mode conversion coefficient of the warm, collisionless problem is independent of electron temperature, T, in the limit of small T, and is equal in magnitude to the mode conversion coefficient of the cold, collisional problem, which is likewise independent of the collision frequency. It also depends on the angle of incidence θ and the vacuum scale length k0L, and for T/mc2(very-much-less-than)1, agrees with earlier, numerical calculations.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 135 (1996), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Cutaneous macroglobulinosis is a rare cutaneous manifestatiou of Waldenstrom's disease. Lesions are thought to result from accumulation of macroglobulin in the dermis and are therefore called IgM storage papules. Ultrastructural findings in the previously reported cases were contradictory and the nature of the deposits was not established by electron microscopy. The purpose of this study was to analyse such deposits by the use of immunoelectron microscopy. A 60-year-old woman had multiple erythemalous papules for 1 year. The histopathological changes consisted of plasmocytic infiltration of the dermis and eosinophiiic deposits. The skin changes and other investigations led to a diagnosis of Waldenstrom's disease. Samples from normal and diseased, skin were analysed by electron microscopy and by immunogold labelling with anti-IgM antibodies, after Lowicryl K4M embedding. An extracellular electron dense granular and filamentous material was observed in the mid- and upper dermis, between and within the collagen bundles. No periodicity was noted and no deposits were seen at the dermoepidermal junction. Immunoelectron mieroscopy showed a positive labelling located only on these deposits, in both normal-appearing skin and in lesions. In this patient, immunoelectron microscopy clearly demonstrated the presence of large amounts of IgM in the dermis, which were found in the lesions of cutaneous macroglobulinosis and in normal skin. These results suggest that the IgM storage papules result from a greater density of deposits rather than a site-specitic accumulation.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background  Although deficiencies in the early components of the complement system were among the first identified genetic risk factors for systemic lupus erythematosus (SLE), only a few studies addressed their significance in patients with cutaneous LE (CLE). Among environmental factors, it was postulated that cigarette smoking might intervene in the pathogenesis of LE.Objectives  To describe the clinical and biological features of patients with CLE and a complement deficiency. A secondary objective was to assess cigarette smoking in patients with CLE.Patients and methods  A retrospective study including all patients diagnosed as having LE between 1995 and 2003 in the Dermatology Department of Strasbourg University Hospital. Patient charts were reviewed and those patients in whom a C4 and/or C2 deficiency was diagnosed were included. Two patients with a combined C2/C4 deficiency were analysed in detail.Results  There were 48 females and 37 males (F/M ratio = 1·3), with a mean age of 41 years at diagnosis; 73% of the patients had chronic LE and 27% subacute CLE. Among 32 screened patients, 24 patients with a mean age of 36 years had a complement deficiency; 17 had a C4A deficiency, five a C4B deficiency and two a combined C4A/C2 deficiency. A high proportion (58%) of these patients was male; 82% of the patients were smokers. This was especially true in males: 94% were smokers compared with 69% of females.Conclusions  Partial deficiency of C4, C2 or C4 and C2 is a common finding in patients with CLE. Most male patients with CLE are smokers. It is thus suggested that the combination of cigarette smoking and complement deficiency could be a risk factor for LE in men.
    Type of Medium: Electronic Resource
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