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  • 1
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of naproxen in elderly patients (1986)
    Springer
    European journal of clinical pharmacology 31 (1986), S. 463-468 
    Details
    ISSN: 1432-1041
    Keywords: naproxen ; osteoarthritis ; elderly patients ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of naproxen have been examined in 13 elderly patients (mean age 84.2 years) and in 9 younger patients (mean age 53.9 years) at the end of a 21 day course of therapy with naproxen 500 mg b.d. The mean pre-dose concentration on days 19, 20 and 21 was significantly higher in the elderly patients than in the controls (60.1 vs. 43.3 µ g · ml−1). The AUC (0–24) was significantly higher in the elderly subjects only when normalized for body weight (9.1 vs. 5.4 µg·ml−1·h kg−1 p⩽0.02). The AUC was significantly higher in the elderly group compared to the control group also in the normalized form. The apparent clearance of naproxen was reduced in the elderly compared to the control patients (315 vs. 628 ml·h−1). The percentage protein binding of naproxen was the same in both groups (99.8%) but the free concentration of naproxen was significantly higher in the elderly patients than in the control patients (141 vs. 89.8 ng·ml−1). Although there was no excess of side effects in the elderly patients it is suggested that when naproxen is given to elderly patients, therapy should be started at the lower end of the dosage range.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00613525
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of Noises of Warfare on the Ear (1940)
    [s.l.] : Nature Publishing Group
    Nature 146 (1940), S. 217-219 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE rapid development of high-explosive * weapons of destruction and attack accompanied by increased blast effects has necessitated increased protection against the possibility of physical injury. The dangers of destructive effects on the sense organs though less obvious have become increasingly ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/146217a0
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Resonance in the External Auditory Meatus (1939)
    [s.l.] : Nature Publishing Group
    Nature 143 (1939), S. 118-118 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IN investigations on the extent to which objective tests can be used to obtain information on the magnitude of the effective amplification hearing aids give to a deaf user, a knowledge of the extent to which resonance occurs in the auditory meatus is of value. In normal human beings such a ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/143118a0
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    Paper (German National Licenses)
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  • 4
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    Unknown
    Auditory Fatigue and Adaptation (1934)
    London, etc. : Periodicals Archive Online (PAO)
    British journal of psychology. 25 (1934/1935) 284 
    Details
    ISSN: 0007-1269
    Topics: Psychology
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:0047-1934-025-00-000027
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  • 5
    Electronic Resource
    Electronic Resource
    Der Hitzdraht-Anemometer und seine Anwendung zur Messung von Blutströmen (1932)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 163 (1932), S. 311-332 
    Details
    ISSN: 1432-1912
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung 1. Die physikalischen Eigenschaften des H.D.-Anemometers werden vom Standpunkt seiner Anwendbarkeit für physiologische Untersuchungen beschrieben. 2. Vorteile und Grenzen des H.D.-Anemometers werden erörtert. Es wird gezeigt, daß bei richtiger Anwendung die H.D.-Registrierung von Blutströmungen eine durchaus zuverlässige, exakte Methode ist. 3. Der Blutstrom durch die unter konstantem Druck durchströmte linke Kranzarterie ist minimal während der Systole und maximal während der Diastole. Diese Beziehung zwischen den verschiedenen Phasen des kardialen Zyklus und der Koronardurchströmung ist stets und unter allen Umständen die gleiche.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01862591
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    Paper (German National Licenses)
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