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Prognostic significance of retinopathy at presentation in adult acute leukemia (1998)

Reddy, S. C. ; Quah, S. H. ; Low, H. C. ; [et al.]

Springer

Annals of hematology 76 (1998), S. 15-18

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ISSN: 1432-0584

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Retinal changes are common in adult acute leukemia patients at presentation, but their prognostic significance is controversial. A 5-year study has been carried out with newly diagnosed acute leukemia patients aged 12–77 years. Seventy-seven cases (49 AML, 28 ALL) were studied prospectively for the presence of intraretinal hemorrhages (IRH), white-centered hemorrhages, cotton-wool spots, and macular hemorrhages. They were treated according to standard chemotherapy protocols, and then achievement of complete remission (CR) and the duration of overall survival (OS) were compared between the groups with and without these different retinal features. No association was found between the presence of any retinal abnormality and CR induction rate, although there was a trend to a lower CR rate among patients with IRH. The median OS of those with IRH was 72 days, compared with 345 days among those without IRH (p=0.002). A WBC at presentation greater than 50×l09/l and age greater than 40 years were also associated with shorter OS (p〈0.0001 and p=0.0045, respectively). However, after regression analysis, IRH remained statistically significant as a poor prognostic indicator (p=0.01).) We conclude that the presence of IRH is an indicator of poor prognosis in acute leukemia.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s002770050354

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Fre-radical addition to olefins, Part 22L. L. T. Vertommen, J. M. Tedder, and J. C. Walton, J. Chem. Res. (S), 18 (1977).. Arrhenius parameters for the addition of trifluoromethyl radicals to vinyl monomers (CH2=CHX) (1978)

Low, H. C. ; Tedder, J. M. ; Walton, J. C.

New York, NY : Wiley-Blackwell

International Journal of Chemical Kinetics 10 (1978), S. 325-334

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ISSN: 0538-8066

Keywords: Chemistry ; Physical Chemistry

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: Relative Arrhenius parameters have been determined for the addition of trifluoromethyl radicals to vinyl chloride (X=Cl), vinyl bromide (X=Br), acrylonitrile (X=CN), methyl vinyl ketone (X=COCH3), 2-methylbut-2-ene, and to iso-butene, taking the rate of addition to ethylene as standard. Addition occurred virtually exclusively at the unsubstituted end of all the olefins. The relative rates of addition at 164°C show very little variation. The preexponential terms for addition to the CH2 ends are constant within experimental error, and the small variations in rate are due principally to the activation energy term. The present results are put on an absolute scale using the previously determined Arrhenius parameters for addition to ethylene and are compared with data for other similar monomers determined previously.

Additional Material: 8 Tab.