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  • 1
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Cellular senescence has been theorized to oppose neoplastic transformation triggered by activation of oncogenic pathways in vitro, but the relevance of senescence in vivo has not been established. The PTEN and p53 tumour suppressors are among the most commonly inactivated or mutated genes in ...
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    The journal of supercomputing 17 (2000), S. 277-289 
    ISSN: 1573-0484
    Keywords: Run-time tools ; interoperability ; on-line monitoring ; distributed systems ; coordination ; behavioral integration ; plug-in architecture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract Tools that observe and manipulate the run-time behavior of parallel and distributed systems are essential for developing and maintaining these systems. Sometimes users would even need to use several tools at the same time in order to have a higher functionality at their disposal. Today, tools developed independently by different vendors are, however, not able to interoperate. Interoperability not only allows concurrent use of tools, but also can lead to an added value for the user. A debugger interoperating with a checkpointing system, for example, can provide a debugging environment where the debugged program can be reset to any previous state, thus speeding up cyclic debugging for long running programs. Using this example scenario, we derive requirements that should be met by the tools' software infrastructure in order to enable interoperability. A review of existing infrastructures shows that these requirements are only partially met today. In an ongoing research effort, support for all of the requirements is built into the OMIS compliant on-line monitoring system OCM.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-2013
    Keywords: Transepithelial electrical resistance Carcinoma Invasion Assay Metastasis Boyden chamber
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. We describe an electrophysiological method for evaluating the intrinsic invasive potency of tumour cells using renal cells as an in vitro assay system. A high-resistance clone of Madin-Darby canine kidney cells (MDCK-C7) was grown to confluency in a filter cup. Transepithelial electrical resistance across the MDCK-C7 monolayer was measured in a commercially available electrode chamber. After a transepithelial electrical resistance of about 4,000 Ω cm2 had been reached, human melanoma or pancreatic carcinoma cells were co-cultivated with the MDCK-C7 monolayer. Both carcinoma cell lines induced resistance breakdown measured after 24 h or later depending on seeding density and cell type. Seeding carcinoma cells on the basolateral surface of MDCK-C7 cells caused a similar decrease in transepithelial resistance of the MDCK-C7 monolayer. Resistance breakdown indicates opening of tight junctions prior to tumour cell invasion. In conclusion, the high-resistance MDCK-C7 cell clone could serve as a valuable biological assay system to determine electrically the metastatic potency of tumour cells in vitro.
    Type of Medium: Electronic Resource
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