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  • 1
    ISSN: 1399-3038
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Histamine plays an important role in the allergic inflammation. Histamin N-Methyltransferase (HNMT) catalyses the major pathway of histamine metabolism in the human lung. A common functional single nucleotide polymorphism (SNP) within the HNMT gene (C314T) was recently related to asthma. We tested this SNP for associations with asthma and asthma associated traits in two German pediatric populations (1. MAS-cohort, n = 888, 85 children with asthma; 2. asthmatic children from Freiburg, n = 176). Non-asthmatic (n = 515) and non-atopic (n = 211) children from the MAS-cohort were used as controls. For genotyping melting curve analyses (Light Cycler System) were applied. In contrast to a previous study, no association of the HNMT 314T allele with asthma, bronchial hyperresponsiveness (BHR) or other asthma related phenotypes could be observed in either study population. We conclude that this SNP might not play a major role in the pathogenesis of asthma or BHR in German children.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1434-6036
    Keywords: PACS. 05.45.Mt Semiclassical chaos (“quantum chaos”) – 03.65.Sq Semiclassical theories and applications
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract: Employing symbolic dynamics for geodesic motion on the tesselated pseudosphere, the so-called Hadamard-Gutzwiller model, we construct extremely long periodic orbits without compromising accuracy. We establish criteria for such long orbits to behave ergodically and to yield reliable statistics for self-crossings and avoided crossings. Self-encounters of periodic orbits are reflected in certain patterns within symbol sequences, and these allow for analytic treatment of the crossing statistics. In particular, the distributions of crossing angles and avoided-crossing widths thus come out as related by analytic continuation. Moreover, the action difference for Sieber-Richter pairs of orbits (one orbit has a self-crossing which the other narrowly avoids and otherwise the orbits look very nearly the same) results to all orders in the crossing angle. These findings may be helpful for extending the work of Sieber and Richter towards a fuller understanding of the classical basis of quantum spectral fluctuations.
    Type of Medium: Electronic Resource
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  • 3
    Publication Date: 2023-07-17
    Language: English
    Type: article , doc-type:article
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  • 4
    Publication Date: 2023-11-03
    Description: Measurable levels of immunoglobulin G antibodies develop after infections with and vaccinations against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). These antibody levels are dynamic: due to waning, antibody levels will drop over time. During the COVID-19 pandemic, multiple models predicting infection dynamics were used by policymakers to support the planning of public health policies. Explicitly integrating antibody and waning effects into the models is crucial for reliable calculations of individual infection risk. However, only few approaches have been suggested that explicitly treat these effects. This paper presents a methodology that explicitly models antibody levels and the resulting protection against infection for individuals within an agent-based model. The model was developed in response to the complexity of different immunization sequences and types and is based on neutralization titer studies. This approach allows complex population studies with explicit antibody and waning effects. We demonstrate the usefulness of our model in two use cases.
    Language: English
    Type: article , doc-type:article
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  • 5
    Publication Date: 2024-04-10
    Description: Collaborative comparisons and combinations of epidemic models are used as policy-relevant evidence during epidemic outbreaks. In the process of collecting multiple model projections, such collaborations may gain or lose relevant information. Typically, modellers contribute a probabilistic summary at each time-step. We compared this to directly collecting simulated trajectories. We aimed to explore information on key epidemic quantities; ensemble uncertainty; and performance against data, investigating potential to continuously gain information from a single cross-sectional collection of model results. Methods We compared July 2022 projections from the European COVID-19 Scenario Modelling Hub. Five modelling teams projected incidence in Belgium, the Netherlands, and Spain. We compared projections by incidence, peaks, and cumulative totals. We created a probabilistic ensemble drawn from all trajectories, and compared to ensembles from a median across each model’s quantiles, or a linear opinion pool. We measured the predictive accuracy of individual trajectories against observations, using this in a weighted ensemble. We repeated this sequentially against increasing weeks of observed data. We evaluated these ensembles to reflect performance with varying observed data. Results. By collecting modelled trajectories, we showed policy-relevant epidemic characteristics. Trajectories contained a right-skewed distribution well represented by an ensemble of trajectories or a linear opinion pool, but not models’ quantile intervals. Ensembles weighted by performance typically retained the range of plausible incidence over time, and in some cases narrowed this by excluding some epidemic shapes. Conclusions. We observed several information gains from collecting modelled trajectories rather than quantile distributions, including potential for continuously updated information from a single model collection. The value of information gains and losses may vary with each collaborative effort’s aims, depending on the needs of projection users. Understanding the differing information potential of methods to collect model projections can support the accuracy, sustainability, and communication of collaborative infectious disease modelling efforts. Data availability All code and data available on Github: https://github.com/covid19-forecast-hub-europe/aggregation-info-loss
    Language: English
    Type: article , doc-type:article
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