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  • 1
    Electronic Resource
    Electronic Resource
    Breast tissue inclusions in axillary lymph nodes (1980)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 4 (1980), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This report describes a female of 54 years with a past history of repeated breast biopsies all showing benign epithelial hyperplasia. The patient subsequently had a simple mastectomy and axillary lymph node biopsy. No evidence of malignancy was found in the specimen but there were numerous foci of epithelial hyperplasia in the breast and one axillary lymph node was extensively replaced by similar tissue. The danger of mistaking benign inclusions in lymph nodes for metastatic malignancy, particularly in tissue examined by cryostat section, is emphasized. The possible aetiology of such lesions is briefly discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1980.tb02958.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    An immunohistochemical study of the presence of c-erbB-2 protein in Paget's disease of the nipple (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 15 (1989), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Tumours from 45 patients with Paget's disease of the nipple have been stained with antibody 21N which was raised against a peptide from the C-terminus of the predicted c-erbB-2 protein. Positive staining was observed in 41 cases (91%). In 42 cases the underlying mammary carcinoma was also available for study. In all but two cases staining was similar in the Paget's cells and the underlying carcinoma whether the latter was purely in situ ductal (35%) or in situ associated with infiltrating carcinoma (65%); the malignant cells in both components were large and pleomorphic and the in situ ductal carcinoma was of the comedo type. In the two exceptions the underlying carcinoma showed different histological features. The significance of the high levels of c-erbB-2 protein in this pattern of mammary carcinoma is considered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1989.tb01610.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Relation between Risk of Breast Cancer and Biological Availability of Estradiol in the Blood: Prospective Study in Guernsey (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 464 (1986), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1986.tb16017.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    A comparative immunohistochemical study of mammary and extramammary Paget's disease and superficial spreading melanoma, with particular emphasis on melanocytic markers (1996)
    Springer
    Virchows Archiv 429 (1996), S. 370-376 
    Details
    ISSN: 1432-2307
    Keywords: Immunohistochemistry ; Melanocytic markers ; Paget's disease ; Melanoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A comparative immunohistochemical study was performed on Paget's disease of the nipple (PDN), extramammary Paget's disease (EMPD) and cutaneous superficial spreading melanoma (SSM) using antibodies to S100, NK1-C3 and HMB45, cytokeratin (CAM 5.2) and c-erb B2 oncoprotein (21N). Conventional histochemical stains for intracytoplasmic mucin and melanin were also done. Of the 20 cases of PDN, positivity was seen in 12 with S100, 16 with NK1-C3, none with HMB45, 20 with CAM 5.2 and 19 with 21N. All 5 cases of EMPD were CAM 5.2 positive and HMB45, S100 and 21N negative. Three EMPD were NK1-C3 positive. All 10 cases of SSM were S100, NK1-C3 and HMB45 positive and all were CAM5.2 and 21N negative. Mucin was demonstrable in 11 cases of PDN and all of EMPD but none of SSM. Melanin was seen in 2 PDN, 3 EMPD and all SSM cases. Identification of mucin and melanin, therefore, proved an unreliable means of distinguishing these diseases. Immunohistochemistry for cytokeratin and HMB45 appear to be the most specific markers in differentiating Paget's disease and SSM. Antibodies to c-erb B2 may also be valuable in this situation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00198442
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  • 5
    Electronic Resource
    Electronic Resource
    Quantitative comparison of estradiol and progesterone receptor contents of primary and metastatic human breast tumors in relation to response to endocrine treatment (1982)
    Springer
    Breast cancer research and treatment 2 (1982), S. 339-346 
    Details
    ISSN: 1573-7217
    Keywords: breast tumors ; estradiol ; progesterone ; receptor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cytosol receptors for estradiol (RE) and progesterone (RP) in breast tumors from women attending one clinic have been analyzed. The analysis involved a single concentration of [3H] ligand and low speed centrifugation of homogenates. Analysis of tumors immediately before the start of first endocrine treatment indicated a poor response rate in patients with tumor RE 〈20 fmol/mg protein. A cut-off value of 20 fmol/mg protein gave the best discrimination between responders and nonresponders in both pre- and postmenopausal patients. An appreciable number of responses (17%) was seen with RP negative tumors (〈5 fmol/mg protein) and analysis of this receptor alone is not recommended. Combined analysis of RE and RP indicated good response rates for RE+ RP+ (64%) and RE − RP+ (67%) tumors and a low response rate for RE− RP− (9%) tumors. Responses also occurred in patients with RE+ RP− tumors (30%). The influence of cut-off value and menopausal status on clinical usefulness of combined RE and RP analysis is discussed. Data are also presented on the clinical value of receptor analyses on primary tumors in predicting the endocrine sensitivity of subsequent metastatic disease. Receptor results for tumors obtained at different times from the same patient are presented and discussed. Receptor phenotype of some tumors does change with time and this is influenced by receptor amount, histological appearance, and intervening treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01805875
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Family history and bilateral primary breast cancer (1985)
    Springer
    Breast cancer research and treatment 5 (1985), S. 201-205 
    Details
    ISSN: 1573-7217
    Keywords: breast cancer ; bilateral disease ; family history
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The prevalence of a family history of breast cancer was established in 54 women with bilateral primary breast cancer and 208 women with unilateral disease. Women with bilateral disease had significantly greater prevalence of family history than women with unilateral breast cancer (P〈0.01). Compared with the unilateral cancers, a significantly greater proportion of bilateral cancers had first degree affected relatives (P〈0.05). Moreover the affected relatives of probands with bilateral disease showed a significantly higher prevalence of bilateral breast cancer compared with the relatives of women with unilateral disease (P = 0.04). The findings suggested that bilateral disease was a characteristic of familial breast cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01805995
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    Paper (German National Licenses)
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