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  • 1
    Electronic Resource
    Electronic Resource
    The Cellular Basis of T-Cell Memory (1989)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Immunology 7 (1989), S. 77-89 
    Details
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.iy.07.040189.000453
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  • 2
    Electronic Resource
    Electronic Resource
    Cytolytic T Lymphocytes (1983)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Immunology 1 (1983), S. 273-306 
    Details
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.iy.01.040183.001421
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  • 3
    Electronic Resource
    Electronic Resource
    Superantigens of Mouse Mammary Tumor Virus (1995)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Immunology 13 (1995), S. 459-486 
    Details
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.iy.13.040195.002331
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  • 4
    Electronic Resource
    Electronic Resource
    Antibody-Dependent Cell-Mediated Cytotoxicity: Heterogeneity of Effector Cells in Human Peripheral Blood (1975)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 4 (1975), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We have compared antibody-dependent cell-mediated cytotoxicity (ADCMC) of human peripheral blood leukocytes (PBL) in three model systems Target cells were 51Cr-labeled mouse mastocytoma cells, chicken erythrocytes (CRBC), and human erythrocytes (HRBC) coated with appropriate heterologous or isologous antisera. Effector cells were characterized on the basis of their adherence, phagocytosis, radiosensitivity, and sedimentation velocity(s) at 1 g. In predominantly mononuclear (Ficoll-Isopaque-purified) PBL preparations (MPBL) HRBC were lysed by an adherent, phagocytic population of cells that was markedly radioresistant. Sedimentation velocity analysis further established that these effector cells were restricted to rapidly sedimenting fractions (s 〉 4.5 mm/hr). On the other hand, mastocytoma cells were lysed by a population of MPBL that was nonadherent, nonphagocytic, and relatively radiosensitive. These cells were mainly restricted to slowly sedimenting fractions (s 〈 4.5 mm/hr) following 1 g. velocity sedimentation. CRBC appeared to be susceptible to lysis by both types of mononuclear effector cell. In some experiments, enriched populations of polymorphonuclear leukocytes (PMN) were isolated. These cells were found to lyse both HRBC and CRBC very efficiently, whereas mastocytoma cells were lysed very little if at all by the same effector populations. Taken together, these results suggest that antibody-coated mastocytoma cells are lysed uniquely by effector cells in human peripheral blood with the physical properties of lymphocytes, whereas antibody-coated HRBC are lysed by both monocytes and PMN, but not by lymphocytes. Antibody-coated CRBC would appear to be lysed by all of the three effector cell types tested.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1975.tb02654.x
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  • 5
    Electronic Resource
    Electronic Resource
    A Comparison of the Effector Cells Involved in Cell-Mediated Lympholysis and Antibody-Dependent Cell-Mediated Cytotoxicity in Man (1975)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 4 (1975), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Some physical and mechanistic properties of cytotoxic lymphocytes and antibody-dependent killer tells were compared. Cytotoxic lymphocytes were measured by the cell-mediated lympholysis (CML) technique after sensitization of human peripheral blood leukocytes (PBL) in unidirectional mixed leukocyte culture (MLC). Kilter cells were measured before and after MLC in an antibody-dependent cell-mediated cytotoxicity (ADCMC) assay using 51Cr-labeled mouse mastocytoma cells as targets Quantitative analysis of the cytotoxic activity of populations separated by velocity sedimentation at 1 g indicated that cytotoxic lymphocytes in MLC were a relatively heterogeneous population of rapidly sedimenting cells that corresponded morphologically to lymphoblasts Further studies in which PBL were separated before MLC suggested that such cytotoxic lymphocytes were derived from small lymphocyte progenitors. Analysis of ADCMC in separated populations showed that most killer cells in PBL had the sedimentation properties of small lymphocytes After stimulation of PBL in MLC. increased ADCMC activity was detected, and the increased activity was associated with a population of rapidly sedimenting cells. Comparison of the sensitivity of cytotoxic lymphocytes and killer cells to inhibition by EDTA, cytochalasin B, and dimethyl sulfoxide showed no significant differences between the two types of effector cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1975.tb02609.x
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  • 6
    Electronic Resource
    Electronic Resource
    T-Cell Activation (1986)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Cell and Developmental Biology 2 (1986), S. 231-253 
    Details
    ISSN: 0743-4634
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.cb.02.110186.001311
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  • 7
    Electronic Resource
    Electronic Resource
    Reversible Changes in Cytolytic T Lymphocyte Function Induced by Hyperthermia (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 7 (1978), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The ability of cytolytic T lymphocytes (CTL) generated in vitro in mixed leucocyte cultures (MLC) to ‘repair’ functional damage induced by moderate hyperthermia has been investigated. Repair of CTL function was assessed in a split dose system in which MLC cells were exposed to a total of 20 min at 43°C delivered either as a single treatment or as two 10 min fractions separated by an interval at 37°C. Significant repair was observed within 15 min at 37°C in the split-dose protocol and maximum repair (corresponding to a 30-100-fold increase in lytic activity) was seen after 1.5-2 h. Repair was both temperature and energy dependent and was apparently related to a reversible lesion in the cytolytic mechanism itself. The effect of a number of metabolic inhibitors (and other agents) on repair was determined, but the precise nature of the heat-induced lesion could not be identified.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1978.tb00439.x
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  • 8
    Electronic Resource
    Electronic Resource
    Selective Lysis of Activated Cells in Oncorna Virus Infection (1997)
    Oxford, U.K. and Cambridge, USA : Blackwell Science Ltd
    Scandinavian journal of immunology 45 (1997), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The authors devised a cytotoxic assay based on cytofluorometric analysis of target surface markers in order to compare lysis exerted in vitro by cytotoxic T lymphocytes (CTLs) on different cell subsets in the context of a single lymphoid target cell population. Using this assay, the authors evaluated when oncorna virus-infected lymphocytes become a suitable target for virus-specific T cell effectors. A lymphocyte population from Moloney-murine leukaemia virus (M-MuLV)-infected (carrier) mice, in which the proliferation of selective Vβ T-cell receptor (TCR) families was induced in response to Mlsa encoded antigens, was utilized as a target. The authors observed that a virus-specific T cell clone exerted lytic activity preferentially against activated cell subsets. Moreover, virus-specific CTLs generated in mixed leucocyte tumour cell cultures (MLTC) were also able to impair the concomitant anti-Mlsa response of lymphocytes from M-MuLV carrier mice. It was found that the proliferative status of oncorna virus-infected target cells played an important role in limiting the in vitro efficacy of the immune response, and it is speculated that this phenomenon might represent an in vivo escape mechanism from immunosurveillance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-3083.1997.d01-411.x
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  • 9
    Electronic Resource
    Electronic Resource
    Regulation of Ig Class Secretion by Soluble Products of Certain T-Cell Lines (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Immunological reviews 78 (1984), S. 0 
    Details
    ISSN: 1600-065X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-065X.1984.tb00475.x
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  • 10
    Electronic Resource
    Electronic Resource
    Rat × Mouse T-cell Hybrids with Inducible Specific Cytolytic Activity (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Immunological reviews 76 (1983), S. 0 
    Details
    ISSN: 1600-065X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-065X.1983.tb01099.x
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