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  • 1
    Electronic Resource
    Electronic Resource
    A case of anaplastic lymphoma kinase-positive anaplastic large cell lymphoma presenting with spontaneous splenic rupture: an extremely unusual presentation (2000)
    Springer
    Virchows Archiv 437 (2000), S. 459-464 
    Details
    ISSN: 1432-2307
    Keywords: Keywords Non-Hodgkin’s lymphoma ; Immunohistochemistry ; ALK1 ; T-cell lymphoma ; Splenic rupture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  In a 22-year-old male with a 10-day history of fever, painful swelling in the left groin, and abdominal complaints, emergency surgery was performed because of spontaneous splenic rupture. At histology, a cellular infiltrate of intermediate-sized atypical lymphocytes was seen in the splenic white pulp, staining for T-cell markers. In addition, CD30 and anaplastic lymphoma kinase 1 (ALK) were diffusely positive, thus, representing a case of anaplastic large cell lymphoma (ALCL), T-cell, ALK-positive, small cell monomorphic variant. ALK-positive ALCL patients generally bear a much better prognosis than patients with T-cell lymphomas, unspecified, or ALK-negative ALCL. Therefore, besides the very unusual clinical presentation, this case highlights the importance of immunostaining for CD30 and ALK in all T-cell lymphomas. This report is the first extensive description of ALK-positive ALCL involvement of the spleen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004280000251
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Skin blood flow and autonomic reactivity in human poikilothermia (1996)
    Springer
    Clinical autonomic research 6 (1996), S. 91-97 
    Details
    ISSN: 1619-1560
    Keywords: skin blood flow ; autonomic reactivity ; hypothermia ; poikilothermia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Autonomic reactivity is pivotal in maintaining a constant body core temperature. Skin vasomotor reflexes and cardiovascular reactivity were investigated in four women (aged 28–37 years) with acquired poikilothermia, during steady-state spontaneous hypothermia (rectal temperature (Tr)=33.7 ± 1.0°C [mean ±SD]) and steady-state normothermia (Tr=36.7 ± 0.3°C), as well as in 12 normothermic control subjects. Baseline finger temperature (Tf) during hypothermia was significantly lower than during normothermia (Tf=32.4 ± 1.2 compared with 36.2 ±0.3°C, respectively), and than in the controls (Tf=34.8 ±0.8°C). No significant differences in baseline skin blood flow and forearm blood flow were found between subjects during hypothermia or normothermia and controls, suggesting a failure of sympathetic drive to counter-regulate hypothermia in the subjects. Skin vasoconstrictor responses to the contralateral cooling test and neck cooling test were markedly attenuated in three subjects, and to the finger cooling test in two subjects, during normothermia compared with hypothermia. Blood presure responses to the Valsalva manoeuvre and head-up tilting were normal in all subjects, whereas the heart rate response to head-up tilting was blunted in three subjects during hypothermia. The responses of blood pressure and forearm blood flow to the cold pressor test in the subjects during both thermal conditions were comparable with the controls. We conclude that in our subjects, without generalized autonomic failure, poikilothermia has to be attributed predominantly to disorders of the central thermoregulatory pathways. Our findings during hypothermia and normothermia indicate that variations in core and skin temperature significantly affect skin vasomotor reactivity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02291229
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    Paper (German National Licenses)
    Fulltext
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