ISSN:
1420-9071
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Feeding various dosages of benzene hexachloride (100, 250, 750 and 1500 ppm) in the diet to weanling male albino rats for 90 days resulted in marked hypertrophy of the adrenals with large, vacuolated cells in the cortex at 750 and 1500 ppm. Accumulation of cholesterol-positive lipids and marked reduction in the activities of steroidogenic enzymes such asΔ 5 3β HSDH, 11β HSDH, G-6-PDH and SDH were seen using histochemical methods in the adrenal cortex of rats fed 750 and 1500 ppm. The results are suggestive of steroidogenic inhibition at 750 and 1500 ppm of dietary BHC while 100 and 250 ppm did not produce any discernible changes in the adrenal cortex.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01959770
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