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Digitale Medien

Preexistence of chronic tubular damage in cases of renal cell cancer after long and high exposure to trichloroethylene (1996)

Brüning, T. ; Golka, K. ; Makropoulos, V. ; [weitere]

Springer

Archives of toxicology 70 (1996), S. 259-260

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Details

ISSN: 1432-0738

Schlagwort(e): Key words Trichloroethylene ; Renal cell cancer ; Tubular damage

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract Substantially more cases of tubular damage were found among renal cell carcinoma patients who had been exposed to high levels of trichloroethylene over many years than among renal cell carcinoma patients who had not been exposed to trichloroethylene. This supports the hypothesis (Goeptar et al. 1995) that chronic tubular damage may be regarded as a necessary precondition for trichloroethylene to exert a nephrocarcinogenic effect. The findings also indicate that the urine protein patterns identified with SDS-PAGE may represent a valuable parameter for effect biomonitoring of persons exposed to high levels of trichloroethylene over many years.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/s002040050271

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