ISSN:
1573-8221
Keywords:
metastasizing
;
melanoma
;
blood
;
nude mice
;
beige/nude mice
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Two human melanoma cell variats-with low and high metastasizing activity-are obtained by successive passaging on mice with combined immunodeficiency. After the development of a subcutaneous tumor, tumor cells are detected only in the bloodstream of animals with a highly metastasizing tumor, in mice with combined immunodeficiency the number of these cells being much greater than that in nude mice. These results indicate a preeminent influence of the nature of tumor cells on the dissemination of metastasizing cells.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02445879
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