ISSN:
1432-2161
Keywords:
Bisphosphonate APD
;
Osteogenesis imperfecta
;
Dual photon absorptiometry
;
Meta-physeal bands
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract A 12-year-old female suffering fromosteogenesis imperfecta (OI) was treated with 3-amino-1-hydroxypropylidene-1,1-bisphosphonate (APD) orally, 250 mg daily, for periods of 2 months, alternating with periods of 2 months of abstinence. Total duration of therapy was 1 year. Radiological and clinical improvement was striking. Furthermore, X-rays of the bones showed large, parallel radio-opaque striae, corresponding exactly to the periods of therapy. These were present in all metaphyses.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00350961
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