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  • 1
    Electronic Resource
    Electronic Resource
    Renal tubular damage after renal stone treatment (1988)
    Springer
    Urological research 16 (1988), S. 101-104 
    Details
    ISSN: 1434-0879
    Keywords: Renal stones ; Renal surgery ; Percutaneous nephrolithotomy ; Extracorporeal shock wave lithotripsy ; Urinary enzymes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 50 patients were studied with respect to renal tubular damage related to open operative, percutaneous and extracorporeal shock wave treatment of renal stones. Preoperative and postoperative urinary N-acetyl-glucosaminidase (NAG) levels were measured as a marker of renal damage. There was no significant evidence of renal tubular damage in patients who underwent a conventional or percutaneous nephrolithotomy; urinary NAG excretion was significantly increased after ischaemic surgery. After extracorporeal shock wave lithotripsy (ESWL) serum NAG levels increased, probably because a damage of the white blood cells in cutaneous and renal circulation, but a slight increase of urinary NAG excretion could suggest a mild renal tubular damage especially in case of more than 2,000 shocks.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00261965
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Urinary NAG excretion after anesthesia-free extracorporeal lithotripsy of renal stones: a marker of early tubular damage (1990)
    Springer
    Urological research 18 (1990), S. 259-262 
    Details
    ISSN: 1434-0879
    Keywords: Urinary enzyme ; N-acetyl-glucosaminidase ; Renal tubular damage ; Extracorporeal shock wave lithotripsy (ESWL) ; Anesthesia-free ; Spark gap ; Piezoelectric ; Renal stone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Second generation lithotripters require a higher number of shocks per session as well as an increased rate of secondary treatments for complete stone disintegration compared to the original spark gap lithotripter. The clinical relevance of biological side effects caused by such treatment are less known. We evaluated urinary excretion of N-acetyl-glucosaminidase (NAG) before and after lithotripsy in 50 patients treated with a low pressure spark gap lithotripter (Dornier HM3) and in 36 patients treated with a piezoelectric lithotripter (Wolf Piezolith 2200) in an attempt to evaluate their side effects on renal tissue. The urinary excretion of NAG increased after both spark gap lithotripsy using the modified HM3 and piezoelectric lithtripsy. These changes may be associated with slight tubular damage that would occur after anesthesia-free lithotripsy in patients subjected both to a high number of shocks and to secondary treatments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294769
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Secretory immunoglobulin A and inhibitory activity of bacterial adherence to epithelial cells in urine from patients with urinary tract infections (1990)
    Springer
    Urological research 18 (1990), S. 305-308 
    Details
    ISSN: 1434-0879
    Keywords: Secretory immunoglobulin A ; Bacterial adhesion ; Urinary tract infection ; Ileocystoplasty
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To assess the role of local immune response against bacterial invasion of the urinary tract we studied 168 patients with bacteriuria. Urinary secretory immunoglobulins A (sIgA) were measured using radial immunodiffusion or enzyme-linked immunosorbent assay (ELISA). In particular, ELISA is a very suitable assay for measuring the low levels of sIgA in urine. Furthermore, we used a quantitative in vitro adherence assay to investigate the attachment of Escherichia coli to human uroepithelial cells after incubation in urine from patients with urinary tract infection. Urine from patients with ileocystoplasty was significantly more potent in inhibiting bacterial adherence than was urine from other groups of patients with urinary tract infection. The presence of high urinary sIgA may help explain the increased antiadherence activity of urine in patients with ileocystoplasty. Mean urinary sIgA in patients with upper urinary tract infection was higher than in patients with uncomplicated infection in the lower urinary tract. Alterations in mucosal immune functions may account for the propensity toward bacterial colonization in women prone to uncomplicated urinary tract infection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00300776
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    Paper (German National Licenses)
    Fulltext
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