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  • 1
    Electronic Resource
    Electronic Resource
    On the possibility of helical structures in olefin/sulfur dioxide copolymers (1982)
    s.l. : American Chemical Society
    Macromolecules 15 (1982), S. 935-937 
    Details
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ma00231a047
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  • 2
    Electronic Resource
    Electronic Resource
    Promoter (4G/5G) plasminogen activator inhibitor-1 genotype in Pima Indians: relationship to plasminogen activator inhibitor-1 levels and features of the insulin resistance syndrome (1996)
    Springer
    Diabetologia 39 (1996), S. 1512-1518 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Plasminogen activator inhibitor-1 ; fibrinolysis ; Pima Indians ; polymorphism ; genetic ; diabetes mellitus ; non-insulin-dependent.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Elevated plasminogen activator inhibitor-1 may contribute to vascular disease in diabetes mellitus. Pima Indians have a low incidence of cardiovascular disease despite having a high prevalence of non-insulin-dependent diabetes mellitus (NIDDM) which in this population is not associated with elevated plasminogen activator inhibitor-1 activity. In Caucasians an insertion/deletion (4G/5G) polymorphism in the promoter region of the plasminogen activator inhibitor-1 gene that has been related to activity levels of its protein in plasma differentially binds repressor and enhancer elements. In 265 Pima Indians (133 diabetic, 132 non-diabetic, 129 male, 136 female, mean age 46.6, range 34–68 years) the promoter genotype frequencies were 23.0 % for 4G/4G, 49.8 % for 4G/5G and 27.2 % for 5G/5G compared to 35.4 %, 50.8 % and 13.8 % respectively (χ2 = 15.3, 2 df, p 〈 0.0005) previously reported in Caucasians with NIDDM. The mean plasma activity levels in the three genotypes in the Pima Indians were 18.2, 19.1 and 18.1 U/ml, respectively. Plasminogen activator inhibitor-1 activities correlated with plasma insulin (r = 0.38, p 〈 0.0001), body mass index (r = 0.24, p 〈 0.0001), and with triglyceride level (r = 0.12, p = 0.054) but there was no relationship between promoter genotype and activity. A steeper regression slope between plasminogen activator inhibitor-1 activity and triglycerides has been observed in Caucasians with the 4G/4G genotype as compared to Caucasians with the other genotypes. This was not found in the Pima population which may indicate a functional difference in this gene associated with reduced cardiovascular risk and may be involved in the lack of association of plasminogen activator inhibitor-1 levels with NIDDM in Pima Indians. [Diabetologia (1996) 39: 1512–1518]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050606
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  • 3
    Electronic Resource
    Electronic Resource
    Soluble vascular cell adhesion molecule-1 and E-selectin levels in relation to vascular risk factors and to E-selectin genotype in the first degree relatives of NIDDM patients and in NIDDM patients (1998)
    Springer
    Diabetologia 41 (1998), S. 460-466 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Adhesion molecules ; NIDDM ; relatives ; insulin resistance ; vascular disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To investigate the metabolic and genetic associations of levels of soluble adhesion molecules, plasma levels of soluble E-selectin and vascular cell adhesion molecule-1 were measured in 60 non-insulin-dependent diabetes mellitus (NIDDM) patients, 60 first-degree relatives of NIDDM patients and 60 control subjects, none of whom displayed clinical features of vascular disease. In addition, E-selectin A561C genotype, coding for a serine to arginine change, was determined. E-selectin levels were elevated in the patient group; 57 [52–63] (mean [95 % confidence intervals]) ng/ml, compared with both relatives; 44 [39–50] ng/ml p = 0.001 and controls 39.5 [36–43] ng/ml p = 0.0001. E-selectin levels correlated with triglycerides, tissue-plasminogen activator and plasminogen activator inhibitor-1 activity in all groups. Levels of E-selectin were related to E-selectin genotype, being higher in subjects possessing the arginine allele (51.4 vs 44.5 ng/ml p 〈 0.05). E-selectin levels were higher in males than females in controls (female 35 [32–39] vs male 45 [40–51] ng/ml p = 0.004), and NIDDM relatives (female 38 [33–44] vs male 52 [45–61] ng/ml p = 0.004) but not in NIDDM patients where levels were similar (female 58 [49–69] vs male 56 [50–62] ng/ml, ns). There was no difference in soluble vascular cell adhesion molecule-1 levels between the three groups (control 640 [598–686] ng/ml, NIDDM relatives 634 [593–678] ng/ml and NIDDM patients 664 [608–725] ng/ml). In controls and patients vascular cell adhesion molecule-1 levels correlated with von Willebrand factor (vWF). The results indicate that levels of E-selectin relate to vascular risk factors in control subjects, NIDDM relatives and NIDDM patients. [Diabetologia (1998) 41: 460–466]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050930
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  • 4
    Electronic Resource
    Electronic Resource
    A randomised controlled pilot study of the management of gestational impaired glucose tolerance (2000)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 107 (2000), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To determine whether a study of a less intensive form of management for impaired glucose tolerance in pregnancy is feasible and whether women would accept randomisation.Design Prospective randomised controlled study.Setting A large district general hospital and a large teaching hospital in West Yorkshire.Sample Seventy women with impaired glucose tolerance in pregnancy.Methods One group monitored plasma glucose up to four times daily. The other group did not monitor plasma glucose at all.Main outcome measures The number of women recruited of those approached and neonatal admissions to special care baby units in each group.Results Sixty-eight of 70 women approached entered the study. There were no statistically significant differences between the groups in neonatal outcome measures. The median number of plasma glucose measurements in the monitored group was 118 (range 0–500), and 19% of women in the monitored group were treated with insulin.Conclusions This study fails to demonstrate any benefit from intensive management of impaired glucose tolerance in pregnancy with additional maternal inconvenience. This pilot study has shown that a large randomised controlled study of the management of impaired glucose tolerance in pregnancy is not only feasible but necessary.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.2000.tb10396.x
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  • 5
    Electronic Resource
    Electronic Resource
    Efficacy of Monensin Against Bovine Coccidiosis in Young Holstein-Friesian Calves (1973)
    Oxford, UK : Blackwell Publishing Ltd
    The @journal of eukaryotic microbiology 20 (1973), S. 0 
    Details
    ISSN: 1550-7408
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Monensin, an anticoccidial antibiotic, was incorporated into pelleted feed and given to 10-week-old Holstein-Friesian calves at 0.25 mg/kg, 1.0 mg/kg, or 2.0 mg/kg of body weight. Inoculated calves were inoculated by drenching with 500,000 sporulated oocysts of Eimeria bovis. Other calves served as inoculated or uninoculated controls. Observations were recorded on oocyst discharge in the feces, clinical signs, weight gain, food consumption, hemoglobin, packed cell volume, total serum protein, sodium and potassium content of the serum, and differential white cell counts.Calves in the inoculated control group developed severe infections, discharged large numbers of oocysts, developed clinical signs and 1 of 5 died. Uninoculated, untreated control calves were essentially free of coccidia. A few calves in the groups which received monensin developed light infections but none of them had clinical signs of coccidiosis. Calves which received the highest and the lowest dosages of monensin gained weight less rapidly than did the uninoculated controls or the animals which received monensin at 1.0 mg/kg of body weight. Inoculated control calves with severe infections had reduced food intake and a significant reduction in weight which was not regained during the experimental period.The only other significant change in any of the parameters measured was a reduction in the total serum protein of inoculated, nonmedicated control calves. The level returned to normal 5 weeks after clinical signs first appeared.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1550-7408.1973.tb06014.x
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  • 6
    Electronic Resource
    Electronic Resource
    THE TREATMENT OF HIRSUTISM WITH CYPROTERONE ACETATE (AN ANTI-ANDROGEN) (1977)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 84 (1977), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The rationale of anti-androgen treatment for hirsutism is explained. The results are presented of treatment with cyproterone acetate of idiopathic hirsutism or hirsutism associated with polycystic ovarian disease. Ten out of 14 patients showed a good response after six months treatment. The response was dramatic in two patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1977.tb12537.x
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  • 7
    Electronic Resource
    Electronic Resource
    AMNIOTIC FLUID TESTOSTERONE AND FETAL SEX DETERMINATION IN THE FIRST HALF OF PREGNANCY (1977)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 84 (1977), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The concentration of freely extractable testosterone in amniotic fluid was measured in 54 patients whose gestational ages ranged from 10 to 20 weeks; 31 of the fetuses were male and 23 were female. The mean amniotic fluid testosterone concentration was significantly higher with a male fetus than with a female fetus. On only 7 out of 31 occasions was the presence of a male fetus associated with amniotic fluid testosterone values below 100 pg/ml, whereas the values associated with a female fetus were never higher than 90 pg/ml. After 14 weeks gestation no amniotic fluid testosterone level was lower than 120 pg/ml in the presence of a male fetus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1977.tb12687.x
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  • 8
    Electronic Resource
    Electronic Resource
    The Treatment of Hirsutism with Cyproterone Acetate (an Anti-androgen). (1977)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 84 (1977), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1977.tb12627.x
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  • 9
    Electronic Resource
    Electronic Resource
    MATERNAL PLASMA ANDROGENS IN EARLY HUMAN PREGNANCY (1980)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 87 (1980), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Mean maternal plasma levels of testosterone, androstenedione, and 5 α-dihydro-testosterone were established from 4 to 16 weeks gestation from twice-weekly blood samples taken from 15 pregnant women. All three hormone levels were raised when compared with the non-pregnant state. There were significant differences in mean maternal plasma testosterone levels at 4 to 5 and 7 to 8 weeks gestation, when comparing women carrying male and female fetuses. Androstenedione levels in a twin pregnancy were increased throughout and testosterone levels were more than 1 SD above the mean from week 15. Steroid levels fell late in the two women who aborted. Hormone levels in three women being given progestogens were within normal limits.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1980.tb04603.x
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  • 10
    Electronic Resource
    Electronic Resource
    A trial of pre-emptive analgesia (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 49 (1994), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The influence of timing of administration of peroperative alfentanil on pain and analgesic requirements after surgery was studied in 60 patients undergoing total abdominal hysterectomy with or without bilateral salpingo-oophorectomy. Thirty patients received alfentanil 7.5μg.kg-1 on induction of anaesthesia, followed by alfentanil 7.5μg.kg-1 90s before surgical incision (group A). Thirty control patients received alfentanil 15μg.kg-1, 10 min after abdominal incision (group B). In addition, 10min after surgical incision both groups received morphine 0.2mg.kg-1, given over a 10min period. The visual analogue scores (median, interquartile range) for pain 24 h after operation were 28.5 mm (11.25–47.0) in group A and 21.0 mm (10.5–47.5)in group B, p = 0.76. There were no differences in visual analogue scores at intermediate times. Morphine consumption in the first 24 h after surgery (median, interquartile range) was 53.5mg (37.25–60.0) in group A and 52.0mg (39.75–71.0) in group B, p = 0.52. We conclude that postoperative morphine consumption and pain scores are no different when alfentanil 15μg.kg-1 is given before or after skin incision for abdominal hysterectomy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1994.tb04363.x
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