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  • 1
    ISSN: 1573-7225
    Keywords: adolescence ; alcohol drinking ; breast neoplasms ; risk factors ; smoking
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objectives: Studies of breast cancer among survivors of the World War II atomic bomb blasts over Japan suggest that the adolescent breast may be particularly sensitive to carcinogenic insult. To further explore that possibility we examined the relationships of cigarette smoking, alcohol consumption, environmental tobacco smoke (ETS) exposure, and medical treatment with ionizing radiation during adolescence with subsequent breast cancer risk. Methods: Data from the Carolina Breast Cancer Study, a population-based, case–control study of breast cancer in North Carolina women aged 20–74years (864 cases, 790 controls), were analyzed. Results: A modest increase in breast cancer risk was suggested for women who began to smoke cigarettes between the ages of 10 and 14 years (OR: 1.5, CI: 0.9–2.5), and for women exposed to ionizing radiation between ages 10 and 19 years to treat or monitor a medical condition (OR: 1.6, CI: 0.5–2.5). Neither exposure to ETS at home prior to age 18 years (OR: 1.1, CI: 0.9–1.3) nor initiation of alcoholic beverage consumption between ages 10 and 15 years (OR: 1.1, CI: 0.6–1.8) appeared to increase risk. Conclusions: Our results are consistent with previous evidence suggesting that some adolescent exposures could influence future breast cancer risk.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-7225
    Keywords: Alcohol drinking ; alcoholic beverages ; case-control study ; colorectal neoplasms ; United States ; women
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Age-specific consumption of beer, wine, and liquor was ascertained by telephone interview from 779 women in Wisconsin (United States) with newly reported diagnosis of carcinoma of the colon and rectum. Population controls (n=2,315) interviewed for this case-control study were randomly selected from Wisconsin driver's license files and Health Care Financing Administration files. Overall, there was a modest indication that high levels of alcohol consumption (11 or more drinks per week) were associated with increased risk of large bowel cancer (adjusted odds ratio [OR]=1.47,95 percent confidence interval [CI]=1.0–2.22). In site-specific analyses, only rectal cancer demonstrated a significant linear trend (P=0.01) with increasing consumption. Significant beverage-specific effects were observed for liquor and colon cancer: the adjusted ORs for 1–2, 3–5, and 6+ drinks per week were 1.12, 1.68, 1.51, respectively (P trend = 0.01). Beer was associated significantly with rectal cancer: the adjusted ORs for 1–2, 3–5, 6–10, and 11+ drinks per week were 1.25, 1.25, 1.58, 2.42, respectively (P trend = 0.02). Wine consumption was associated inversely with these cancers. These relationships appeared to be consistent for recent, past, and total lifetime consumption, and were not attributable to differences in dietary habits.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1573-7225
    Keywords: Breast cancer ; detection ; females ; mammography ; screening ; United States
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Early detection is advocated widely as the best method to reduce the high rate of breast cancer mortality in women. The purpose of this study was to describe the detection histories of women with breast cancer and to identify factors related to the method of detection. During the period 1988–90, 3,197 women with invasive breast cancer, identified through the Wisconsin (United States) tumor registry, were interviewed. The method of cancer detection (classified as self, screening mammography, or clinical breast examination [CBE]) was analyzed using polychotomous logistic regression. Fifty-five percent (1,754/3,197) of the women found their own cancers, while 35 percent (1,122/3,197) were detected by screening mammography. Compared with self-detection, the likelihood of non-localized disease was significantly lower for tumors detected by mammography (odds ratio [OR]=0.3, 95 percent confidence interval [CI]=0.2–0.4) and CBE (OR=0.6, CI=0.4–0.7). The likelihood of cancer being detected by screening mammography increased with increasing age, education, number of prior mammograms, family history, and body mass index (weight/height2) (BMI). Women in the highest BMI quintile were 2.3 times (CI=1.7–3.0) more likely than women in the lowest BMI quintile to have their cancers diagnosed by mammography. This association most likely results from breast tumors being more difficult to palpate in heavier women.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1573-7225
    Keywords: adolescence ; breast neoplasms ; epidemiology ; exercise ; female
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objectives: Some epidemiologic studies suggest that adolescent physical activity reduces subsequent breast cancer risk. To examine this question further, we analyzed data on physical activity at age 12 that had been collected as part of the Carolina Breast Cancer Study (CBCS). Methods: The CBCS is a population-based, case-control study of 527 white and 337 African-American cases and 790 controls, frequency-matched on age and race. Respondents were asked whether, and to what extent, they engaged in four specific activities at age 12 (walking to school, biking to school, competitive training, performing vigorous household chores). Results: Women who reported participation in any of the four activities had a modest reduction in breast cancer risk (odds ratio (OR): 0.8, 95% confidence interval (CI): 0.6–1.0). Using an index measuring approximate number of activity episodes per week, analyses revealed modest inverse relationships for nearly all levels of activity relative to no reported activity; a weighting of the index by metabolic equivalent scores produced similar results. Conclusions: Our findings support the hypothesis that adolescent physical activity may protect against adult breast cancer, even at moderate levels.
    Type of Medium: Electronic Resource
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