ISSN:
1573-8221
Keywords:
vasorenal hypertension
;
aldosterone
;
Verospiron
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract The role of the mineralocorticoid function of the adrenals in rats was studied during the development of two forms of experimental vasorenal hypertension (stenosis of one renal artery while the opposite kidney remains intact, and ischemia of the solitary kidney). The sodium-retaining action of aldosterone was blocked immediately after the operation by Verospiron. In rats with unilateral stenosis of the renal artery and the opposite kidney intact, a marked increase in the daily urinary aldosterone excretion was observed; in animals with ischemia of the solitary kidney no activation of adrenal mineralocorticoid function was observed. Verospiron sharply inhibited the development of the first form of renal hypertension but did not affect the blood pressure in rats with stenosis of the artery of the solitary kidney.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00833144
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