ISSN:
1432-0584
Keywords:
Key words Pentosan polysulfate
;
Thrombocytopenia
;
Stroke
;
Cerebrovascular disease
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract We report a patient who developed severe thrombocytopenia and ischemic stroke following pentosan polysulfate treatment. An ELISA test employed in type-II heparin-induced thrombocytopenia was highly positive. To our knowledge, this is the first case in which this test has been performed in a pentosan polysulfate-induced thrombocytopenia (PIT). Our data suggest that the antibody against pentosan polysulfate-platelet complex also cross-reacts with heparin-platelet factor 4 complex. Due to its greater sensitivity and wider availability, this ELISA test should be used in cases where PIT is suspected.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002770050202
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