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  • 1
    Electronic Resource
    Electronic Resource
    Feasibility of obtaining breast epithelial cells from healthy women for studies of cellular proliferation (1997)
    Springer
    Breast cancer research and treatment 43 (1997), S. 201-210 
    Details
    ISSN: 1573-7217
    Keywords: breast cancer ; cell proliferation ; dietary fat ; Ki-67 ; mammographic densities ; PCNA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Increased dietary fat intake and rate of breastepithelial cell proliferation have each been associated withthe development of breast cancer. The goal ofthis study was to measure the effect ofa low fat, high carbohydrate diet on therate of breast epithelial cell proliferation in womenat high risk for breast cancer. Women wererecruited from the intervention and control groups ofa randomized low fat dietary intervention trial, breastepithelial cells were obtained by fine needle aspiration,and cell proliferation was assessed in these samplesusing immunofluorescent detection of Ki-67 and PCNA. Theeffects of needle size and study group oncell yield and cytologic features of the cellswere also examined. Fifty three women (20 inthe intervention group and 33 in the controlgroup) underwent the biopsy procedure. Slides from 38subjects were stained for Ki-67 and from 14subjects for PCNA. No cell proliferation (fluorescence) wasdetected for either Ki-67 or PCNA in anyof the slides. Epithelial cell yield and numberof stromal fragments were greater with a largerneedle size. Numbers of stromal fragments and bipolarnaked nuclei were greater in the low fatas compared to the control group but nodifferences in epithelial cell yield were observed betweenthe two groups. This study confirms that fineneedle aspiration biopsy is a feasible method ofobtaining epithelial cells from women without discrete breastmasses, but suggests that cell proliferation cannot beassessed using Ki-67 and PCNA in such samples.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005784628237
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    A comprehensive linkage analysis for myocardial infarction and its related risk factors (2002)
    [s.l.] : Nature Publishing Group
    Nature genetics 30 (2002), S. 210-214 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Coronary artery disease and myocardial infarction (MI) are leading causes of death in the western world. Numerous studies have shown that risk factors such as diabetes mellitus, arterial hypertension and hypercholesterolemia contribute to the development of the disease. Although each risk factor by ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng827
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    A study of diet and breast cancer prevention in Canada: why healthy women participate in controlled trials (1993)
    Springer
    Cancer causes & control 4 (1993), S. 521-528 
    Details
    ISSN: 1573-7225
    Keywords: Canada ; cancer prevention ; clinical trials ; dietary fat ; females ; participation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Little research has been undertaken to determine why healthy people agree to enroll in randomized controlled trials of cancer prevention. This study describes the beliefs of Canadian women participating in a trial designed to determine the effect of reducing dietary fat on the development of breast cancer. Healthier eating, nutritional counseling, contributing to science, and helping others were the most frequently cited advantages of participation. Weight control and general better health were specifically associated with the dietary regimens. Attending appointments and difficulties when eating out were the main disadvantages of participation. Suggestions that would promote adherence to the trial protocol also were elicited. Responses cited most often included opportunities to meet other participants, more nutritional counseling (particularly psychological tips), updates about the trial, and more recipes. Attention should be paid to these suggestions as they characterize some of the major determinants of adherence behavior.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00052427
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Self-reported physical and emotional health of women in a low- fat, high-carbohydrate dietary trial (Canada) (1998)
    Springer
    Cancer causes & control 9 (1998), S. 601-610 
    Details
    ISSN: 1573-7225
    Keywords: Diet ; dietary fat ; health status ; women's health
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objectives: While decreased intake of dietary fat may have significant positive effects on women's health by reducing the risk of cancer and other diseases, little research has been carried out to determine the potential adverse effects of dietary fat reduction. This study compares the self-reported physical and emotional health of 402 low fat intervention and control group participants in the Canadian Diet and Breast Cancer Prevention Trial. Methods: Subjects who had been participating in the dietary intervention trial for at least 2 years completed 3 mailed questionnaires: two designed to assess physical and emotional health (MOS 36-Item Short-Form Health Survey (SF-36) and the Women's Health Questionnaire (WHQ)) and a Health Practices Survey. Results: There were no significant differences between the study groups on total scores or any of the subscales/health domains for the SF-36 or the WHQ. In premenopausal women only, intervention group subjects scored significantly lower on the vasomotor symptoms scale, indicating less symptom experience. Frequency of visits to physicians and alternative health practitioners were not significantly different between the study groups. Conclusions: The results of this study suggest that participation in a low-fat, high-carbohydrate dietary intervention did not have any detrimental effects on participants'; self-reported physical health or emotional well-being.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008827428524
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    Paper (German National Licenses)
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