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  • 1
    Electronic Resource
    Electronic Resource
    Sequential treatment with bolus and continuous infusion of recombinant factor VIIa for hip arthroplasty in a patient with haemophilia A and inhibitor (2002)
    Oxford, UK : Blackwell Science Ltd
    Haemophilia 8 (2002), S. 0 
    Details
    ISSN: 1365-2516
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. We describe a total arthroplasty of the hip in a 40-year-old male patient with haemophilia A and a high-titre inhibitor to factor VIII, treated with rFVIIa. The patient received sequential therapy first as bolus in the early postoperative phase in order to obtain appropriate haemostasis and then as continuous infusion with lower doses to avoid frequent episodes of bleeding without a higher consumption of product. After an initial dose of 150 µg kg−1 for the first five days after surgery, we used bolus doses of 120–90 µg kg−1 every 2.5–3 h, achieving plasma FVII:C levels above 40 U mL−1. We then continued with continuous infusion at decreasing doses 15–7 µg kg−1 h−1 for 12 days (FVII:C 19–7 U mL−1). There were no bleeding complications nor signs of clotting activity. The rehabilitation programme was continued without prophylactic treatment. The total consumption of rFVIIa was 6.3 mg kg−1, implying a saving of at least 30% of the product with respect to previous publications.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2516.2002.00690.x
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  • 2
    Electronic Resource
    Electronic Resource
    Interdemic variation in haematocrit and lactate dehydrogenase in the African cyprinid Barbus neumayeri (2004)
    Oxford, UK; Malden, USA : Blackwell Science Ltd
    Journal of fish biology 65 (2004), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: This study evaluated whether the African cyprinid Barbus neumayeri from Rwembaita Swamp (low-oxygen) and Njuguta River (high-oxygen) in the Kibale National Park, Uganda differed in traits related to aerobic and anaerobic metabolic potential. Haematocrit was measured as an index of blood oxygen-carrying capacity, and tissue activities and isozyme composition of lactate dehydrogenase (LDH) were measured as indices of tissue anaerobic capacity. To address whether site-dependent differences were acute responses v. longer-term adjustments to environmental conditions, these variables were measured in fish sampled shortly after collection and after laboratory maintenance under well-aerated conditions. In fish sampled in the field, those from the low-oxygen site had significantly higher haematocrit, but this difference disappeared after long-term laboratory maintenance. In contrast, fish from the low-oxygen site had higher liver LDH activities than fish from the high-oxygen site, and this difference persisted during laboratory maintenance. Polymorphism was detected at both the LDH-A and LDH-B loci, and genotype frequencies for LDH-B differed significantly between collection sites. These results demonstrate physiological, biochemical and genetic differences in B. neumayeri from habitats differing in dissolved oxygen availability and suggest both acute and long-term responses to local environmental conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0022-1112.2004.00515.x
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  • 3
    Electronic Resource
    Electronic Resource
    2-Phenylcyclopropane-1-spiro-4'-(2'-benzylthio-4',5'-dihydro-6'H-1',3'-thiazine)-5'-spiro-2''-oxirane (CTO) (1977)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 33 (1977), S. 3913-3915 
    Details
    ISSN: 1600-5740
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0567740877012424
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  • 4
    Electronic Resource
    Electronic Resource
    The crystal and molecular structures of two derivatives of a spiro-oxazolone: a cis vs trans X-ray study (1978)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 34 (1978), S. 593-597 
    Details
    ISSN: 1600-5740
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0567740878003593
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  • 5
    Electronic Resource
    Electronic Resource
    Polymerization of aqueous liquid-crystalline allyldimethyldodecylammonium bromide (1999)
    Springer
    Colloid & polymer science 277 (1999), S. 1215-1219 
    Details
    ISSN: 1435-1536
    Keywords: Key words Allyldimethyldodecylammonium bromide ; Liquid crystals ; Polymerization ; Polymerizable surfactant
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Allyldimethyldodecylammonium bromide was polymerized by γ-ray irradiation in both hexagonal and cubic mesophases, and the conversion–time curves were obtained. The maximum conversion was about 35%, and the polymer remained in the liquid-crystalline structure formed by the nonpolymerized monomers. The influence of polymerization on the distribution of water in the different types related to the hydrophilic surfaces of microstructures was studied using Fourier transform infrared spectroscopy. The incomplete polymerization was explained by steric constraints in the liquid-crystalline structures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003960050513
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  • 6
    Electronic Resource
    Electronic Resource
    Germination response to temperature, salinity, light and depth of sowing of ten tropical dune species (1992)
    Springer
    Oecologia 92 (1992), S. 343-353 
    Details
    ISSN: 1432-1939
    Keywords: Dunes ; Germination ; Mexico ; Ecophysiology ; Neotropic
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract This study describes the germination responses of ten tropical dune species to several factors to which their seeds are exposed in the field. Species studied were: three sand dune endemics (Amaranthus greggii, Palafoxia lindenii, and Trachypogon gouini), three pantropical coastal species (Sesuvium portulacastrum, Sporobolus virginicus and Ipomoea stolonifera) and four cosmopolitan grasses also found inland (Panicum repens, Panicum maximum, Pappophorum vaginatum and Andropogon glomeratus). Six species germinated when exposed to different constant temperatures. Four required temperature fluctuation (S. portulacastrum, P. lindenii, S. virginicus, P. repens). Light promoted germination of three species (S. Portulacastrum, P. vaginatum, P. lindenii). Species varied in their degree of sensitivity to salinity. Seeds of T. gouini, I. stolonifera, S. portulacastrum, P. repens, P. Maximum and P. vaginatum were able to germinate under some of the salinity concentrations. Not all species were able to recover after being transferred to distilled water. Seedling emergence was inhibited when seeds were buried. This response was related to depth and to seed size. S. portulacastrum and S. virginicus were the most affected. Nitrates only affected germination response of two species. Seed age promoted germination under a wider range of conditions. P. lindenii showed very heterogeneous responses depending on seed cohort. No dormancy mechanisms were found, other than a thermoperiod and/or light requirement for some of the species. Cosmopolitan grasses tolerated both sand burial and salinity, although the endemics were the most successful in emerging from sand burial; coastal pantropicals were very tolerant to high saline concentrations and recovered completely.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00317460
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  • 7
    Electronic Resource
    Electronic Resource
    DisseminatedScedosporium inflatum infection in a patient with acute myeloblastic leukemia (1991)
    Springer
    European journal of clinical microbiology & infectious diseases 10 (1991), S. 759-761 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A case of disseminatedScedosporium inflatum infection occurring in a neutropenic patient with acute myeloblastic leukemia is reported.Scedosporium inflatum was isolated from skin lesions, blood, urine and vitreous cultures. Amphotericin B treatment was ineffective in avoiding hematogenous spread. At autopsy, hyphae and ovoid conidia with truncate bases consistent with the morphology ofScedosporium inflatum were found in the lungs, kidneys, myocardium, liver, thyroid, spleen, lymph nodes, brain and the left eye. This is the first report of disseminatedScedosporium inflatum infection and the first time this organism has been isolated from a patient in Europe.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01972505
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  • 8
    Electronic Resource
    Electronic Resource
    Visceral leishmaniasis in patients infected with the human immunodeficiency virus (1997)
    Springer
    European journal of clinical microbiology & infectious diseases 16 (1997), S. 898-903 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The experience with 52 episodes of visceral leishmaniasis diagnosed in 43 patients is reported. The most common symptoms were fever (81%), splenomegaly (65%), hepatomegaly (63%), and pancytopenia (73%). In 79% of the patients, CD4+ cell counts were 〈100 cells/mm3. Prior or simultaneous diagnosis of AIDS was made in 29 (67%) patients. Diagnosis was considered fortuitous in 19% of the episodes. In 27% of the episodes, the diagnosis was made on the basis of demonstration of parasites outside the reticuloendothelial system, chiefly blood (7 cases) and gastrointestinal mucosa (5 cases). Parasites were frequently observed or cultured from blood (22/37 episodes) or the digestive tract (8/9 episodes). High antimony doses were more effective than low doses in achieving clinical or parasitological cure (rate of cure, 80% vs. 40%, p=0.11). Severe toxicity was observed in six (11.7%) of the 51 treated episodes. Severe AIDS-related diseases [odds ratio (OR) 10, p〈0.05] and CD4+ counts (OR 12, p〈0.05) were independent factors for early death. Prophylaxis with monthly pentamidine was not useful in reducing relapses of visceral leishmaniasis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01700556
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  • 9
    Electronic Resource
    Electronic Resource
    Direct search methods for the molecular conformation problem (1994)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Computational Chemistry 15 (1994), S. 627-632 
    Details
    ISSN: 0192-8651
    Keywords: Computational Chemistry and Molecular Modeling ; Biochemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Computer Science
    Notes: An important area of research in computational biochemistry is the design of molecules for specific applications. The design of these molecules, which depends on the accurate determination of their three-dimensional structure, can be formulated as a global optimization problem. In this article, we present results from the application of a new conformation searching method based on direct search methods. We compare these results to some earlier results using genetic algorithms and simulated annealing. © 1994 by John Wiley & Sons, Inc.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcc.540150606
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  • 10
    Electronic Resource
    Electronic Resource
    Study on the System CoSeO4—NiSeO4—H2O at 30°C Crystal Structure of CoSeO4 · 5 H2O (1985)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 528 (1985), S. 183-190 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Das System CoSeO4-NiSeO4—H2O bei 30°C. Kristallstruktur des CoSeO4 · 5 H2OEs wird das System CoSeO4—NiSeO4—H2O bei 30°C untersucht. Die Kristallwerden aus wäßriger Lösung durch langsames Eindampfen erhalten. Die gefundenen Phasen sind CoSeO4 · 5 H2O und NiSeO4 · 6 H2O; CoSeO4 · 6 H2O wird dann gefunden, wenn die Kristallisation der Co-Verbindung in Gegenwart von Ni erfolgt. Diese drei Phasen zeigen einen begrenzten Ersatz des Metalls auf Grund von Röntgenpulverdaten. Die Kristallstruktur des CoSeO4 · 5 H2O ist triklin, a = 6.435(1), b = 10,703(2), c = 6,220(1) Å, α = 98,71(1), β = 109,60(2), γ = 75,54(1)°, P1, Z = 2. Verfeinerung bis zu R = 0,032 für alle beobachteten Reflexe. Die Kristallstruktur ist isostrukturell zu CuSO4 · 5 H2O und besteht aus Ketten von Co(H2O)4-Ionen parallel zu [110], die brückengebunden über die SeO4-Anionen sind. Das fünfte Wassermolekül wirkt als Puffer.
    Notes: A study of the system CoSeO4—NiSeO4—H2O at 30°C has been carried out. Crystals were obtained by slow evaporation from a water solution. The identified phases were CoSeO4 · 5 H2O and NiSeO4 · 6 H2O, but CoSeO4 · 6 H2O is identified when the crystallization of Co compound is carried out in presence of Ni. The three phases show a limited replacement of metal according to X-ray powder results. The crystal structure of CoSeO4 · 5 H2O has been solved, the come pound is triclinic, a = 6.435(1), b = 10.703(2), c = 6.220(1) Å, α = 98.71(1), β = 109.60(2), γ = 75.54(1)°, P1, Z = 2. Refinement was terminated at R = 0.035 for all observed reflections. The crystal structure is isostructural to CuSO4 · 5 H2O and consists of Co(H2O)4 ions chains parallel to [110] μ-linked by the SeO4. The fifth water molecule acts as buffer.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19855280921
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