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  • 1
    Electronic Resource
    Electronic Resource
    The role of Mg2+ in the regulation of the structural and functional steady-states in rat liver mitochondria (1983)
    Springer
    Journal of bioenergetics and biomembranes 15 (1983), S. 217-234 
    Details
    ISSN: 1573-6881
    Keywords: Mg2+ levels ; respiratory states ; phosphorylative efficiency ; rat liver mitochondria
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Physics
    Notes: Abstract A possible relationship between mitochondrial Mg2+ levels, structural configurations, and functional steady states has been studied in rat liver mitochondria. The results show that the concentration of mitochondrial Mg2+ in respiratory state 4 is definitely higher than in respiratory state 3. The metabolic transition from state 3 to state 4 and vice-versa is associated with reversible influx-efflux of about 10 nmol of Mg2+ per mg protein. The net uptake of this aliquot of Mg2+ is a necessary condition in order for the metabolic transition to state 4, both structurally and functionally, to occur. This process requires a threshold concentration of external Mg2+ greater than 5 mM. The phosphorylative mechanism does not appear to depend on the presence or absence of external Mg2+. The role of Mg2+ on the attainment and maintenance of the structural and functional steady state 4 seems to be correlated with its regulatory effect on the concentration of the mitochondrial Pi.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00743942
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Iron-Induced Oxidant Stress Leads to Irreversible Mitochondrial Dysfunctions and Fibrosis in the Liver of Chronic Iron-Dosed Gerbils. The Effect of Silybin (2000)
    Springer
    Journal of bioenergetics and biomembranes 32 (2000), S. 175-182 
    Details
    ISSN: 1573-6881
    Keywords: Iron ; oxidant stress ; liver mitochondria (gerbil)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Physics
    Notes: Abstract Hepatic iron toxicity because of iron overload seems to be mediated by lipid peroxidation ofbiological membranes and the associated organelle dysfunctions. However, the basicmechanisms underlying this process in vivo are still little understood. Gerbils were dosed with weeklyinjections of iron—dextran alone or in combination with sylibin, a well—known antioxidant,by gavage for 8 weeks. A strict correlation was found between lipid peroxidation and the levelof desferrioxamine chelatable iron pool. A consequent derangement in the mitochondrialenergy-transducing capability, resulting from a reduction in the respiratory chain enzymeactivities, occurred. These irreversible oxidative anomalies brought about a dramatic drop intissue ATP level. The mitochondrial oxidative derangement was associated with thedevelopment of fibrosis in the hepatic tissue. Silybin administration significantly reduced bothfunctional anomalies and the fibrotic process by chelating desferrioxamine chelatable iron.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005512014280
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    ‘Free’ iron, as detected by electron paramagnetic resonance spectroscopy, increases unequally in different tissues during dietary iron overload in the rat (1996)
    Springer
    BioMetals 9 (1996), S. 98-103 
    Details
    ISSN: 1572-8773
    Keywords: electron paramagnetic resonance spectroscopy ; free iron ; iron overload ; lipid peroxidation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract ‘Free’ iron concentration, as determined by electron paramagnetic resonance (EPR) spectroscopy, and lipid peroxidation (LPO), as determined by thiobarbituric acid test, were assessed in the lung, heart, liver, spleen, brain and kidney of rats subjected to experimental iron overload. Two tests, Desferal- and NO-available iron, were used to measure ‘free’ iron and gave comparable results. The most pronounced accumulation of ‘free’ iron was observed in liver, kidney and spleen. Differences between control and iron loaded animals increased during the initial 90 days of treatment. Between 90 and 180 days ‘free’ iron concentration reached a steady state level, or even decreased, as in the case of liver. Lipid peroxidation level, measured in the organs of both treated and matched controls, did not give any significant difference during the initial 90 days of treatment. A significant augmentation was observed in liver, kidney, spleen and heart at 180 days. The results of the present research show that, under conditions of moderate siderosis, the occurrence of LPO is partially related to the level of ‘free’ iron.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00188097
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    Paper (German National Licenses)
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