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  • 1
    Electronic Resource
    Electronic Resource
    Combination treatment using thymosin α1 and interferon after cyclophosphamide is able to cure Lewis lung carcinoma in mice (1990)
    Springer
    Cancer immunology immunotherapy 32 (1990), S. 154-160 
    Details
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A combination treatment with thymosin α1 (200 µg/kg) for 4 days, followed by a single injection of murine interferon α/β (3 × 104 international units/mouse), starting 2 days after cyclophosphamide treatment (200 mg/kg, single injection) demonstrated a dramatic and rapid disappearance of tumor burden in mice bearing Lewis lung carcinoma (3LL) tumor. The effectiveness of this new chemoimmunotherapy protocol was evident even on the long-term survival in a high percentage of animals, and was statistically significant when compared to treatment with the single agents in conjunction with chemotherapy or to chemotherapy itself. The same combination immunotherapy treatment strongly stimulated natural killer activity and cytotoxicity against autologus 3LL tumor cells in 3LL-tumor-bearing mice treated with cyclophosphamide, whereas treatments with each agent singly did not alter or only slightly modified the cytotoxic activity towards Yac-1 or 3LL target cells. Selective depletion with antibodies showed that killer cells stimulated by combination chemoimmunotherapy treatment bear phenotypic characteristics of asialo-GM1-positive cells. A histological study has shown a high number of infiltrating lymphoid cells in the tumors obtained from mice treated with combination chemoimmunotherapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01771450
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Protective effect of interferon β on human T cell leukaemia virus type I infection of CD4+ T cells isolated from human cord blood (1993)
    Springer
    Cancer immunology immunotherapy 37 (1993), S. 97-104 
    Details
    ISSN: 1432-0851
    Keywords: HTLV-I ; Interferon ; Cord blood ; 2′,5′-oligo(A) synthetase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The present study shows the effect of human interferon β (IFNβ) on the susceptibility of highly purified cord blood CD4+ T cells to infection with the human T cell leukaemia virus type I (HTLV-I). Unfractionated cord blood mononuclear cells (CBMC), or a separated CD4+ T cell subpopulation (CBCD4) were exposed to HTLV-I by cocultivation with a chronically infected virus-donor cell line. The results show that presence of proviral DNA as well as virus transcription was markedly reduced by IFNβ in both populations, indicating that this cytokine protects not only unfractionated CBMC but also purified CBCD4 cells from virus infection. Moreover IFNβ treatment caused 60%–80% inhibition of virus expression in CBCD4, assayed as the presence of virus core protein p19. This study demonstrates that IFNβ is able to inhibit HTLV-I infection of CBMC through a mechanism that does not necessarily involve cell-mediated natural or antigen-dependent immunity afforded by CBMC subpopulations distinct from targets of HTLV-I infection. Therefore it is reasonable to conclude that IFNβ has a direct protective effect on CBCD4, through induction of antiviral resistance/activity in target cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01517041
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Modulation of natural killer activity by thymosin alpha 1 and interferon (1985)
    Springer
    Cancer immunology immunotherapy 20 (1985), S. 189-192 
    Details
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A single injection of αβ-interferon (αβ-IFN) (30 000 units/mouse), a major biological modifier of natural killer (NK) cytolytic activity, strongly stimulated NK activity in normal mice, as expected, while the same treatment did not statistically alter the NK response in cyclophosphamide (CY)-suppressed animals. We investigated the possibility of thymosin α1 cooperating with αβ-IFN in boosting NK activity in CY-suppressed animals. The results show that treatment with thymosin α1 (200 μg/kg) for 4 days, followed by a single injection of αβ-IFN 24 h before testing, strongly restored NK activity in CY-suppressed mice. Thymosin α1 was, moreover, able to accelerate the recovery rate of NK activity in bone marrow reconstituted murine chimeras. Taken together the data support the concept that the synergic effect between thymosin α1 and αβ-IFN could be the result of effects on differentiation of the NK lineage at different levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00205574
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    Paper (German National Licenses)
    Fulltext
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