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  • 1
    ISSN: 1520-6041
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 135 (1996), S. 0 
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Abstract Moraxella catarrhalis is one of the major pathogens of respiratory infections and has the ability to attach to the pharyngeal cells via fimbriae. We characterized the epithelial cell receptor to which fimbriate M. catarrhalis binds. Neuraminidase pretreatment of pharyngeal epithelial cells resulted in a significant decrease of M. catarrhalis attachment, suggesting interaction with the sialic acid component. The attachment was not decreased in M. catarrhalis pretreated with 2 and 1 mg/ml of fucose, N-acetyl-neuraminic acid, N-acetyl-glucosamine, N-acetyl-galactosamine, acetyl-salicylic acid and colominic acid. However, M. catarrhalis treated with gangliosides M1, M2, D1a, D1b and T1a at a concentration of 2.5 μg/ml had significantly decreased the attachment compared to the control. In contrast treatment with gangliosides M3 and asialoganglioside M1 did not decrease the attachment of M. catarrhalis and thereby provided evidence for specificity of the inhibition. Concentration dependent effects of ganglioside M2 on the attachment were also observed. Other fimbriate isolates of M. catarrhalis showed decrease in attachment after treatment with ganglioside M2. However there was no effect on attachment when a nonfimbriate isolate was treated with ganglioside M2. This study indicates that the receptor of fimbriate M. catarrhalis on pharyngeal epithelial cells resides in the sequences of ganglioside M2.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1573-7373
    Keywords: intracranial tumors ; gliomas ; boron neutron capture therapy ; BSH pharmacokinetics ; boron uptake
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We evaluated retrospectively the pharmacokinetics and boron uptakeof BSH (mercaptoundecahydrododecarborate) for Boron Neutron Capture Therapy(BNCT) in 123 patients undergoing craniotomy for intracranialtumors. The pharmacokinetics revealed that BSH could moveeasily from blood to the peripheral organs; itwas retained there and elimination was very slow.BSH after intra-arterial infusion (IA) was found tomove into the peripheral organs more easily thanafter intra-venous (IV) infusion. In patients with malignant glioma, the average valuesof boron concentration in tumor and the tumorto blood ratio (T/B ratio) after IA infusionwere 26.8 ± 19.5 μg/g (range, 6.1–104.7 μg/g)and 1.77 ± 1.30 (range, 0.47–6.65) respectively. Onthe other hand, after IV infusion the valueswere 20.9 ± 12.2 μg/g (range, 7.0–39.7 μg/g)and 1.30 ± 0.65 (range, 0.61–2.94) respectively. Thedifferences are not statistically significant. Boron uptake inmalignant glioma was about three times higher thanlow grade glioma. We found a good correlationbetween boron uptake and time interval from BSHinfusion, and 15–20 hours after BSH infusion theboron concentration in tumor was above 20 μg/g10B in 69% of the malignant glioma patients;T/B ratio was above one in 75%, andabove two in 44% of them. We recommend intra-venous infusion of BSH clinically sinceit is safer, and results in sufficient boronconcentration in tumor, and the planned irradiation mightbe optimal around 15–20 hours after the BSHinfusion for treating malignant glioma.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1573-6792
    Keywords: MEG ; Source Localization ; Localization accuracy ; Neural network ; Error back propagation algorithm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The purpose of this study was to examine the usefulness of BP neural networks for source localization of MEG. Since the performance of this method does not depend on the complexity of brain parameters and source models, a homogeneous brain model and a single current dipole source are assumed for convenience. Localization accuracy was examined in relation to the configuration and scale of the network. As a result, average error for position and moment estimations was within 2%, while the maximum error was about 5%. It was therefore concluded that the neural network method was useful for MEG source localization, though some improvements are still necessary.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Brain topography 3 (1990), S. 209-218 
    ISSN: 1573-6792
    Keywords: Deviation ratio topography ; Assessment of hemispheric dominance ; Intraoperative monitoring ; Movement-related cortical potentials
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Sophisticated spectral analysis and mapping of the EEG with computer techniques provides objective and reliable diagnostic information, which is superior to that obtained by naked-eye observation, even by experienced clinicians. In our department, a topographic system was introduced as one of major adjuncts to EEG examination in 1980, and we devised our own software (dynamic topography, compound dynamic topography, deviation ratio topography) to facilitate its clinical application. Topographic mapping is applied to assessment of the dominant hemisphere, evaluation after medical and surgical treatment, spatial localization of epileptic foci, and intraoperative monitoring for cerebral hypoperfusion. Besides these surgical applications, topographic analysis has contributed to human neurophysiology, for instance in determining the participation of the dentate-thalamic tract in movement-related cortical potentials. Our experience of the neurosurgical and neurophysiological applications of topographic mapping will be presented.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1573-6792
    Keywords: Source Localization ; Optimization Techniques ; Sophisticated Head Models ; Localization Accuracy ; Neural Networks ; Error-Back-Propagation Algorithm ; Automated-Dipole Tracing ; Data Reduction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Source localization in the brain remains an ill-posed problem unless further constraints about the type of sources and the head model are imposed. Human head is modeled in various ways depending critically on the computing power available and/or the required level of accuracy. Sophisticated and truly representative models may yield more accurate results in general, but at the cost of prohibitively long computer times and huge memory requirements. In conventional source localization techniques, solution source parameters are taken as those which minimize an index of performance, defined relative to the model-generated and clinically measured voltages. We propose the use of a neural network in the place of commonly employed minimization algorithms such as the Simplex Method and the Marquardt algorithm, which are iterative and time consuming. With the aid of the error-backpropagation technique, a neural network is trained to compute source parameters, starting from a voltage set measured on the scalp. Here we describe the methods of training the neural network and investigate its localization accuracy. Based on the results of extensive studies, we conclude that neural networks are highly feasible as source localizers. A trained neural network's independence of localization speed from the head model, and the rapid localization ability, makes it possible to employ the most complex head model with the ease of the simplest model. No initial parameters need to be guessed in order to start the calculation, implying a possible automation of the entire localization process. One may train the network on experimental data, if available, thereby possibly doing away with head models.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1573-6792
    Keywords: Somatosensory evoked potential ; N20-P20 dipole ; P20 ; Brain tumor ; Central sulcus ; Neural Network
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We have applied the artificial neural network method to estimate the N20-P20 dipole from scalp SEP potentials, and have investigated the rotation of the dipole moment caused by the compression effect of a brain tumor (para-Rolandic tumor) adjacent to the central sulcus. The variation of the frontal P20 potential was demonstrated by the rotation of the N20-P20 dipole moment in 8 cases of para-Rolandic tumor. By estimation of the rotation of the dipole moment, it may be possible to obtain preoperative information regarding the relation between the central sulcus and the tumor.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1861-387X
    Keywords: Schwannoma ; Brain tumor ; Cathepsin D ; Lysosomal protease ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The immunohistochemical localization of cathepsin D (CD) was demonstrated for the first time in 54 schwannomas (32 intra- and 22 extracranial; 47 benign and 7 malignant) and 5 normal nerve fibers. Granular or vesicular CD-reactive structures were observed in all normal Schwann cells. All tumors contained CD-reactive tumor cells, although the population of CD-reactive tumor cells, the density, intracellular localization, and morphology of CD-reactive structures, and the intensity of CD immunore-activity varied from case to case, portion to portion, and cell to cell, differing variously from those in normal Schwann cells. The variations were greater in malignant than in benign schwannomas. In mildly degenerate tumor cells, CD immunoreactivity was increased, possibly in response to the increased intracellular degenerate proteins, suggesting that the mechanism of induction of lysosomal proteases preserved in normal cells is not affected by the process of neoplastic transformation. In lesions of severe degeneration or necrosis, CD immunoreactivity was lost in most tumor cells but was strong in macrophages invading the lesions and perivascular regions. CD immunoreactivity was observed at various intensities in tumor cells in the Antoni type A area but not in most tumor cells in the Antoni type B area, suggesting that Antoni type B lesions show degenerative changes. The presence of CD-reactive tumor cells in all tumors examined and strong CD immunoreactivity observed at the invasion front of tumors in some cases of benign or malignant schwannoma suggests the possible role of CD in tumor invasion in some cases.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Brain tumor pathology 14 (1997), S. 53-57 
    ISSN: 1861-387X
    Keywords: Gliomatosis cerebri ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 52-year-old man was admitted to our clinic with severe headache and bilateral papilledema. Magnetic resonance (MR) images on admission demonstrated diffuse swelling of the cerebral cortex without formation of a tumor mass. Biopsy revealed diffuse infiltration with neoplastic glial cells. After radiation and chemotherapy, the MR images returned to normal. The morphological and neurological features of the present case met the criteria for gliomatosis cerebri. However, this patient showed an unusually good response to radiation and chemotherapy.
    Type of Medium: Electronic Resource
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