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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Archives of toxicology 67 (1993), S. 179-185 
    ISSN: 1432-0738
    Keywords: Hepatic porphyria ; Cytochrome P450 ; Suicide substrate ; Ferrochelatase ; Species difference ; Porphyrins ; N-Methyl protoporphyrin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract 1-[4-(3-Acetyl-2,4,6-trimethylphenyl)-2,6-cyclohexanedionyl]-O-ethyl propionaldehyde oxime (for short ATMP) is a novel porphyrogenic agent causing hepatic protoporphyria in the mouse. Mice given a single dose of the drug showed 24 h later a 70% inhibition of liver ferrochelatase and marked accumulation of protoporphyrin. These changes were not seen in similarly treated rats, guinea pigs, hamsters or chick embryos. A green pigment was isolated from the liver of mice treated with ATMP and identified by its electronic absorption spectrum and chromatographic properties on HPLC asN-methyl protoporphyrin. The ATMP pigment markedly inhibited the enzyme ferrochelatase in vitro, thus supporting its identification asN-methyl protoporphyrin. Two inhibitors of liver cytochrome P450, compound SKF 525-A and piperonyl butoxide, when given before ATMP, afforded protection against ATMP-induced porphyria and production ofN-methyl protoporphyrin, suggesting a role of cytochrome P450 in the induction of the metabolic disorder. The most likely interpretation for these findings is therefore that ATMP is metabolized in the mouse to a reactive species, which in turn alkylates the haem moiety of liver cytochrome P450, thus producingN-methyl protoporphyrin. This inhibits ferrochelatase and, as a secondary response, protoporphyrin accumulates. This pathway of metabolism to the postulated reactive metabolite presumably does not occur to a significant extent in the other species examined and hence is the likely basis for the species difference in protoporphyria.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Il nuovo cimento della Società Italiana di Fisica 10 (1988), S. 693-708 
    ISSN: 0392-6737
    Keywords: Impurity and defect absorption in solids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Description / Table of Contents: Riassunto Sono state studiate per la prima volta le forme di riga delle bande di assorbimento dei centriF A in alogenuri alcalini. Il nuovo metodo usato per questa indagine è basato sulla determinazione attraverso misure di luminescenza della sovrapposizione fra le bandeF A1 eF A2 . I risultati sperimentali sono stati confrontati con i valori dedotti da bandeF A teoriche di diverse forme. La forma di riga dell'assorbimento a bassa temperatura, sia per i centriF A (I) in KCl: Na+ sia per i centriF A (II) in KCl: Li+ e RbCl: Li+, è approssimata molto meglio da una somma di due curve Lorentziane che da quella di due bande Gaussiane o Poissoniane. Questo risultato rivela una differenza imprevista rispetto ai centriF, il cui assorbimento ha una forma di riga Poissoniana alle stesse temperature.
    Abstract: Резюме Впервые исследуются формы линий зон поглощения дляF A центров в щелочно-галоидных соединениях. Предлагается новый метод исследования. Этот метод основан на определении перекрытия междуF A иF A2 зонами из измерений люминесценции. Экспериментальные результаты сравниваются с вычисленными величинами, полученными из теоретическихF A зон различной формы. ДляF A (I) центров в KCl: Na+ иF A (II) центров в KCl: Li+ и RbCl: Li+ форма линии поглощения при низких температурах оказывается ближе к сумме двух Лоренцевых кривых, а не двух Гауссовых или Пуассоновых зон. Этот результат обнаруживает неожиданное отличие отF центров, форма линии поглощения которых, как известно, представляет Пуассонову кривую при тех же температурах.
    Notes: Summary The lineshapes of the absorption bands ofF A centres in alkali halides have been studied for the first time. The new method used for this investigation is based on the determination of the overlap between theF A1 andF A2 bands from luminescence measurements. The experimental results have been compared with calculated values deduced from the theoreticalF A bands of different shapes. For bothF A (I) centres in KCl: Na+ andF A (II) centres in KCl: Li+ and RbCl: Li+ the absorption lineshape at low temperature is much closer to a sum of two Lorentzian curves than that of two Gaussian or Poissonian bands. This result shows an unexpected difference with theF centres, whose absorption lineshape is known to be Poissonian at the same temperatures.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Il nuovo cimento della Società Italiana di Fisica 17 (1995), S. 411-424 
    ISSN: 0392-6737
    Keywords: Solid alkali halides ; Optical rotatory power ; Impurity and defect absorption in solids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Summary The evaluation of site symmetry distortion for an impurity ion in cubic crystals is a problem which obtained attention from a number of investigators during the last decade. So far, all approaches were based on multi-parameter fittings of the experimental results by some theoretical curves. A new technique, described in this paper, makes it possible to obtain the site symmetry distortion parameter in a straightforward fashion directly from the experimental data. The method is based on precise measurements of the light polarization azimuth for a beam transmitted by a crystal with reorienting centres. results are reported forF A (Li) centres in KCl and RbCl.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 191 (1961), S. 363-366 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] OUTBREAKS of cutaneous porphyria, involving several thousand cases, have occurred in districts of south-eastern Turkey since 19561. Affected individuals, predominantly children, are said to exhibit photosensitivity, hepatomegaly and porphyrinuria but no abdominal or neurological symptoms. Poisoning ...
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    BBA - Biochimica et Biophysica Acta 68 (1963), S. 100-107 
    ISSN: 0006-3002
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    BBA Specialized Section on Nucleic Acids and Related Subjects 68 (1963), S. 100-107 
    ISSN: 0926-6550
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Physics and Chemistry of Solids 51 (1990), S. 1053-1059 
    ISSN: 0022-3697
    Keywords: Color centers ; F"A center off-axis ; KF : Li^+ ; alkali halides
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 0003-2697
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Free Radical Biology and Medicine 15 (1993), S. 301-309 
    ISSN: 0891-5849
    Keywords: Bilirubin ; Cytochrome P450IA1 ; Desferrioxamine ; Free radicals ; Polyhalogenated biphenyls ; Trolox
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Chromatography B: Biomedical Sciences and Applications 562 (1991), S. 749 
    ISSN: 0378-4347
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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