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  • 1
    Electronic Resource
    Electronic Resource
    Mechanism of allosteric activation of glycogen phosphorylase probed by the reactivity of essential arginine residues. Identification of an arginine residue involved in the binding of glucose 1-phosphate (1981)
    s.l. : American Chemical Society
    Biochemistry 20 (1981), S. 2354-2360 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00511a044
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Proton nuclear magnetic resonance contact shifts of octahedral iron(II), cobalt(II), and nickel(II) imidazole complexes (1975)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 97 (1975), S. 2113-2117 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00841a019
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    A workbench for computational geometry (1994)
    Springer
    Algorithmica 11 (1994), S. 404-428 
    Details
    ISSN: 1432-0541
    Keywords: Algorithms ; Computational geometry ; Implementation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics
    Notes: Abstract We describe the design and implementation of a workbench for computational geometry. We discuss issues arising from this implementation, including comparisons of different algorithms for constant factors, code size, and ease of implementation. The workbench is not just a library of computational geometry algorithms and data structures, but is designed as a geometrical programming environment, providing tools for: creating, editing, and manipulating geometric objects; demonstrating and animating geometric algorithms; and, most importantly, for implementing and maintaining complex geometric algorithms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01187021
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Benthic and pelagic fish biomass of the upper continental slope off eastern Tasmania (1989)
    Springer
    Marine biology 101 (1989), S. 11-25 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Benthic and pelagic fishes were sampled east of Maria Island, Tasmania, at two-monthly intervals from April 1984 to June 1985, from the surface to the bottom (500 m depth), using commercial-sized trawls. Biomass was calculated by the “area swept/volume filtered” method and divided by estimated catchability coefficients so that catches from the two sampling gears could be combined. Of the 54 families caught, three (Myctophidae, Squalidae, Sternoptychidae) contributed 25% of the 115 species. Most benthic and dispersed species were caught regularly, whereas most pelagic species occurred only occasionally and in low numbers, although a core group was always present. Total fish biomass was high (range=77 to 532 g m-2; x= 390 g m-2), due almost entirely to the myctophid Lampanyctodes hectoris (over 90% of the biomass). Benthic biomass was relatively low and stable, but derived from many species. Pelagic biomass was high, fluctuated widely and was composed of a few species. Biomass was highest in summer: Maurolicus muelleri increased by a factor of 200, Diaphus danae by 50, and L. hectoris, Macruronus novaezelandiae and Lepidorhynchus denticulatus by almost 10. Peaks in biomass may correlate with the interactions of the subtropical convergence and the East Australian Current and the resultant marked seasonal cycle in water temperature, nutrients and primary productivity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00393474
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  • 5
    Electronic Resource
    Electronic Resource
    Glycerol and dihydroxyacetone metabolizing enzymes in fission yeasts of the genus Schizosaccharomyces (1987)
    Springer
    Archives of microbiology 147 (1987), S. 263-267 
    Details
    ISSN: 1432-072X
    Keywords: Schizosaccharomyces ; Glycerol dehydrogenases ; Dihydroxyacetone kinase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The only species of fission yeasts capable of growing on glycerol or dihydroxyacetone were Schizosaccharomyces pombe and S. malidevorans. When growing on glycerol or grown on glucose until it was exhausted, these species contained glycerol:NAD+ 2-oxidoreductase and dihydroxyacetone kinase but no glycerol kinase, consistent with utilization of glycerol via dihydroxyacetone. When grown to exhaustion of glucose, S. octosporus, S. slooffiae and S. japonicus contained dihydroxyacetone kinase but no glycerol:NAD+ 2-oxidoreductase or glycerol kinase. Prior to exhaustion of glucose in the medium, all species contained dihydroxyacetone kinase, all species except S. japonicus contained glycerol:NADP+ 2-oxidoreductase, and only S. pombe and S. malidevorans contained glycerol:NAD+ 2-oxidoreductase. Possible roles for the glycerol:NAD+ 2-oxidoreductase, glycerol:NADP+ 2-oxidoreductase and dihydroxyacetone kinase in metabolism of glycerol and dihydroxyacetone are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00463486
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  • 6
    Electronic Resource
    Electronic Resource
    A non-cholinergic function for acetylcholinesterase in the substantia nigra: Behavioural evidence (1984)
    Springer
    Experimental brain research 54 (1984), S. 513-520 
    Details
    ISSN: 1432-1106
    Keywords: Acetylcholinesterase ; Substantia nigra ; Microinfusion ; Turning behaviour ; Dopamine receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Acetylcholinesterase is released from substantia nigra neurons, independently of cholinergic transmission. In an attempt to discover the functional significance of this phenomenon, the behavioural effects of injecting acetylcholinesterase into one substantia nigra of the rat were investigated. Following a single injection of the enzyme, intraperitoneal amphetamine evoked circling behaviour in a direction away from the side of injection. Purified acetylcholinesterase with a similar electrophoretic mobility to the endogenous secreted form, was far more potent in eliciting circling than much higher activities of commercial enzyme, consisting of several molecular species of acetylcholinesterase. Similar infusions of butyrylcholinesterase did not induce circling. Depending upon the amount of enzyme initially given, the behavioural effects of a single injection of acetylcholinesterase persisted for up to thirty days. During this period apomorphine, administered systemically, induced transient circling towards the acetylcholinesterase-treated side. It is concluded that secreted acetylcholinesterase has a functional significance within the substantia nigra, independent of cholinergic transmission. This released enzyme could exert long-term changes in the activity of the nigrostriatal system, involving modification of dopamine striatal receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00235476
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  • 7
    Electronic Resource
    Electronic Resource
    Different patterns of corticopontine projections from separate cortical fields within the inferior parietal lobule and dorsal prelunate gyrus of the macaque (1986)
    Springer
    Experimental brain research 63 (1986), S. 265-278 
    Details
    ISSN: 1432-1106
    Keywords: Corticopontine projections ; Inferior parietal lobule ; Prelunate gyrus ; Area 7 ; Intraparietal sulcus ; Pontine nuclei
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Corticopontine projection patterns were studied after injections of an 3H-leucine and 3H-proline mixture into each of four distinct cortical fields within the inferior parietal lobule and dorsal prelunate gyrus. Different preferential patterns of pontine labeling were observed for each of the four cortical areas studied. Multiple injections across the dorsal aspect of the prelunate gyrus (area DP) yielded scattered patches of label limited to the dorsolateral pontine nuclear region. A single injection within the lateral intraparietal area (area LIP), located in the caudal portion of the lateral bank of the intraparietal sulcus resulted in a series of labeled patches across the dorsal tier of cells stretching across the dorsal portions of the dorsolateral, peduncular and dorsal pontine nuclei. Injection of the cortex on the caudal aspect of the inferior parietal convexity (area 7a) produced multiple patches of label along the lateral margin of the ventral, lateral, and dorsolateral nuclei. Injection of area 7b resulted in label along the lateral aspects of the ventral, lateral and dorsolateral nuclei, as seen with area 7a injections, as well as additional label in the ventromedial portions of the ventral, peduncular and paramedian pontine nuclei. These results provide supporting anatomic evidence for the functional subdivision of the inferior parietal lobule and dorsal aspect of the prelunate gyrus and provide new information about the organization of cortical projections to the primate pontine nuclei.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00236844
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  • 8
    Electronic Resource
    Electronic Resource
    A comparison of labetalol and prazosin combined with atenolol in non-responders to atenolol plus hydrochlorothiazide in uncomplicated hypertension (1985)
    Springer
    European journal of clinical pharmacology 28 (1985), S. 507-511 
    Details
    ISSN: 1432-1041
    Keywords: hypertension ; labetalol ; prazosin ; hydrochlorothiazide ; side-effects ; therapeutic efficacy ; atenolol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary After screening two local populations in the northern part of The Netherlands for hypertension, patients with a diastolic pressure (DP) between 95 and 120 mmHg were treated daily either with 50 mg hydrochlorothiazide or 100 mg atenolol. Non-responders were given the combination and if necessary the dose of atenolol was increased to 200 mg. Non-responders to the latter combination were randomized and treated either with 50 mg hydrochlorothiazide and labetalol or with 50 mg hydrochlorothiazide, 200 mg atenolol and prazosin. If after 1 month a DP≤90 mmHg had been reached the patient was reassessed after a further 3 months. If a DP〉90 mmHg was found the dose of labetalol or prazosin was increased and the patient was re-examined after 1 month. This protocol was followed until the maximum dose was reached or adverse reactions prevented a further increase in dosage. During 6 months of treatment there was a further drop in systolic and diastolic blood pressures under both regimens of, respectively, 8.6 and 2.4 mmHg for labetalol, and 7.7 and 5.0 mmHg for the prazosin group. At the end of the period the average daily doses of labetalol and prazosin were 1256 mg and 4.3 mg, respectively. There was no significant difference in the average number of complaints between the labetalol and the prazosin group.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00544059
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  • 9
    Electronic Resource
    Electronic Resource
    Comparison of atenolol 50 mg and 100 mg as initial treatment in uncomplicated mild to moderate hypertension (1985)
    Springer
    European journal of clinical pharmacology 28 (1985), S. 351-352 
    Details
    ISSN: 1432-1041
    Keywords: atenolol ; hypertension ; side-effects ; dose-response relationship ; initial treatments
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary After screening a local population in the northern part of The Netherlands for hypertension, 59 patients with a diastolic pressure (DP) between 95 and 130 mmHg were randomized and treated either with 50 mg atenolol (n=29) or 100 mg atenolol (n=30) for 1 month. There was no significant difference between the two treatments, neither in the fall in systolic and diastolic pressures nor in the number of complaints reported. It is concluded that in the initial treatment of uncomplicated mild to moderate hypertension, 100 mg atenolol has no advantage over a 50 mg dose.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00543336
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  • 10
    Electronic Resource
    Electronic Resource
    Comparison of labetalol, propranolol and hydralazine in hypertensive out-patients (1982)
    Springer
    European journal of clinical pharmacology 21 (1982), S. 457-460 
    Details
    ISSN: 1432-1041
    Keywords: hypertension ; propranolol ; hydralazine ; labetalol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In a randomised cross-over trial the combination labetalol/hydrochlorothiazide was compared with the combination of propranolol/hydralazine/hydrochlorothiazide in 34 uncomplicated hypertensive patients, who were not satisfactorily controlled with hydrochlorothiazide 50 mg alone. The elevated diastolic pressure (D.P.) in 27 patients responded satisfactorily to the labetalol schedule and in 28 patients to the propranolol/hydralazine schedule. No difference was found in the rate of decrease of D.P., nor in the disappearance of hypertension — related complaints. Although the duration of the washout between treatments was at least one month, treatment was significantly more efficacious during the second period. Labetalol pre-treatment especially seemed to enhance the effect of subsequent propranolol/hydralazine administration. Side effects due to therapy were rare and were not related to any particular treatment. The median daily dose of labetalol in responders was 600 mg and that of propranolol/hydralazine 120/60 mg (in both therapies hydrochlorothiazide 50 mg was given in addition). Patients showed a slight preference for the labetaol medication. It is concluded that labetalol/hydrochlorothiazide and propranolol/hydralazine/hydrochlorothiazide are equally satisfactory in the treatment of uncomplicated hypertension.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542038
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