Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Hautinfektionen durch Mycobacterium gordonae Fallbericht und Literaturübersicht (1996)
    Springer
    Der Hautarzt 47 (1996), S. 771-775 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Atypische Mykobakteriose ; Mycobacterium gordonae ; Key words Atypical mycobacteriosis ; Mycobacterium gordonae
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Mycobacterium gordonae is an atypical mycobacterium of very low pathogenic potential. It is widely distributed in soil and water and often detected on the mucous membranes of healthy persons. In recent years, there have been numerous reports of infections by M. gordonae in immunocompromised patients. In contrast, only four cases of skin infections by M. gordonae in immunocompetent patients have been published. We report on another patient without evidence of immunodeficiency who developed an atypical mycobacteriosis after a thorn injury during gardening. M. gordonae was isolated by tissue culture. The skin lesion cleared completely after treatment with doxycycline for three months.
    Notes: Zusammenfassung Mycobacterium gordonae zählt zu den atypischen Mykobakterien von sehr geringer Pathogenität. Es ist in Erdreich und Wasser weit verbreitet und häufig auf Schleimhäuten gesunder Personen nachzuweisen. Bei immunsupprimierten Patienten wurde in den letzten Jahren wiederholt über Infektionen durch M. gordonae berichtet. Hautinfektionen bei immunkompetenten Patienten wurden dagegen erst viermal beschrieben. Wir berichten über einen weiteren immunkompetenten Patienten, bei dem sich im Anschluß an eine Dornenverletzung während der Gartenarbeit eine atypische Mykobakteriose entwickelte. In der Gewebekultur wurde M. gordonae nachgewiesen. Eine Therapie mit Doxycyclin über 3 Monate führte zur vollständigen Abheilung.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050050507
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Diagnostik, Klinik und Therapie der frühen Chromoblastomykose an einem Fallbeispiel (1996)
    Springer
    Der Hautarzt 47 (1996), S. 693-700 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Chromoblastomykose ; Mykid ; Urlaubsdermatose ; Itraconazol ; Key words Chromoblastomycosis ; Mykid ; Tourist dermatosis ; Itraconazole
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Despite the availability of modern antimycotics, which produce high cure rates in early infections, the therapy of advanced chromoblastomycosis is still unsatisfactory. An initial chromoblastomycosis caused by a hitherto unidentified species of the genus Phialophora was diagnosed in a 46-year-old teacher. The organism was isolated twice at an interval of 6 weeks from a partly psoriasiform, partly verrucous lesion on the 4th toe. The infection was apparently acquired 4 years ago during a holiday at Cape Verde. Treatment with itraconazole (Sempera), 200 mg/day, and amphotericin B (Ampho-Moronal) cream for 6 weeks initially resulted in rapid regression. However, 4 weeks after cessation of therapy, the Phialophora species was cultured again from skin scrapings. Complete healing was achieved after re-treatment with itraconazole for 20 weeks at the same dosage in combination with topical amorolfine and local hyperthermia. Until now, no relapse has occured. The present case demonstrates that this rare disease, which mainly occurs as a traumatic mycosis in the rural population of tropical regions, must be included in the differential diagnosis of psoriasiform or verrucous skin lesions and also included in the list of diseases which may be acquired while on vacation in exotic locations.
    Notes: Zusammenfassung Die Therapie der fortgeschrittenen Chromoblastomykose ist trotz moderner Antimykotika immer noch unbefriedigend, während die Behandlung im Frühstadium hohe Heilungsraten erwarten läßt. Bei einem 46 Jahre alten Lehrer konnte eine initiale Chromoblastomykose durch eine noch unbekannte Spezies der Gattung Phialophora diagnostiziert werden. Der Erreger wurde 2mal im Abstand von 6 Wochen aus einem teils psoriasiformen, teils verrukösen Herd an der 4. Zehe isoliert, die Infektion ist vermutlich im Rahmen eines Badeurlaubs 4 Jahre zuvor auf Cap Verde acquiriert worden. Unter 6wöchiger Therapie mit Itraconazol (Sempera) 200 mg/Tag und einer Amphotericin-B-haltigen Zubereitung (Ampho-Moronal-Creme) kam es bei guter Verträglichkeit zunächst zu einer raschen Rückbildung des Hautbefunds. Vier Wochen nach Therapieende ließ sich der Erreger jedoch erneut aus Schuppenmaterial anzüchten. Eine nochmalige, nun 20wöchige Itraconazoltherapie in obiger Dosierung führte in Kombination mit topischem Amorolfin und lokaler Hyperthermie zu einer nun vollständigen, rezidivfreien Abheilung. Der vorliegende Fall zeigt, daß diese seltene Erkrankung – als Verletzungsmykose vornehmlich bei der Landbevölkerung tropischer Regionen auftretend – auch als sog. Urlaubsdermatose im Zug des Ferntourismus in die Differentialdiagnostik psoriasiformer oder verruköser Hautveränderungen einbezogen werden muß.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050050491
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Hefen der Gattung Trichosporon Identifizierung, Epidemiologie und Bedeutung der dermatologischen Krankheitsbilder (1996)
    Springer
    Der Hautarzt 47 (1996), S. 913-920 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter ; Trichosporon Epidemiologie ; Onychomykosen ; Key words Trichosporon ; Epidemiology ; Onychomycosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Based on molecular data, the genus Trichosporon was recently reclassified. Six human pathogenic species, which are closely related to specific types of infections can be differentiated. By means of commercial test systems and simple key criteria according to Gueho et al. [15], 44 isolates that had been identified as Tr. cutaneum between 7/92 and 1/96, were reclassified. The evaluation of clinical data also included 66 isolates that had not been preserved, and 27 strains of Tr. inkin. Trichosporon species were found in 4.8% of all yeast isolates (3.8% Tr. cutaneum, 1% Tr. inkin). Nearly every other isolate of Tr. cutaneum was cultivated from nail material, while Tr. inkin was mainly isolated from skin in the anogenital region. In 38 cases, reclassification revealed Tr. mucoides; Tr. ovoides and Tr. asteroides were identified in 3 cases each, while Tr. asahii, an especially remarkable pathogen in systemic mycoses, was not found. Clinically, isolates of Tr. mucoides were predominant in toenail mycoses which might be considered in the therapy of onychomycosis. Furthermore, isolates from the skin should be evaluated with respect to the increasing incidence of systemic Trichopsoron mycoses.
    Notes: Zusammenfassung Das Genus Trichosporon wurde kürzlich auf der Basis molekularer Daten reklassifiziert. 6 humanpathogene Species konnten abgegrenzt werden, die eine enge Beziehung zu umschriebenen Krankheitsbildern aufweisen. Mit Hilfe von kommerziellen Testsystemen und einfachen Schlüsselkriterien nach dem Vorschlag von Gueho et al. [15] wurden 44 aus dem Zeitraum 7/92–1/96 zunächst als Tr. cutaneum identifizierte Isolate reklassifiziert. In die Auswertung der klinischen Daten wurden weitere 66 nicht mehr zugängliche Isolate sowie 27 Tr. inkin Stämme einbezogen. Trichosporon-Hefen finden sich in 4,8% aller Hefe-Isolate (3,8% Tr. cutaneum, 1% Tr. inkin). Nahezu jedes zweite Tr. cutaneum Isolat stammt dabei aus Nagelmaterial, während Tr. inkin vor allem von der Haut des Genitoanalbereichs isoliert werden kann. Die Reklassifikation erbrachte in 38 Fällen die Diagnose Tr. mucoides und je 3 mal Tr. ovoides bzw. Tr. asteroides, während Tr. asahii als besonders beachtenswerter Erreger von Systemmykosen nicht gefunden wurde. Klinisch zeigt sich eine Häufung von Tr. mucoides bei Zehnagelmykosen, was in der Onychomykosetherapie berücksichtigt werden könnte. Therapeutische Überlegungen bei Hautisolaten sollten zudem die steigende Inzidenz systemischer Trichosporon-Mykosen einbeziehen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050050531
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Growth requirements and nitrogen metabolism of Malassezia furfur (1998)
    Springer
    Archives of dermatological research 290 (1998), S. 277-282 
    Details
    ISSN: 1432-069X
    Keywords: Key words Malassezia furfur ; Growth requirements ; Nitrogen metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Investigations on the nutrient requirements of Malassezia yeasts led to the preparation of a new minimal medium consisting of an amino nitrogen and a lipid source, which only allowed the growth of the species M. furfur. Carbohydrates, electrolytes, vitamins and trace elements were not required. Using the basal medium, a nitrogen auxanogram for M. furfur was developed, which allowed investigation of the assimilation of 22 amino acids and 9 further nitrogen sources. With the exception of cysteine, all amino acids were metabolized, as were ammonium salts, urea, creatine, creatinine, uric acid and allantoin. KNO3, however, failed to support growth. Depending on the source used, the yeast cells changed micromorphologically: both oval and round forms were induced. Assimilation of several amino acids resulted in dimorphism, especially in the case of glycine and serine. The cell yield differed significantly depending on the nitrogen source; short-chain unbranched amino acids were utilized most readily. Thus, M. furfur can be characterized as a relatively undemanding yeast species which is optimally adapted to the superficial skin environment. All other lipid-dependent Malassezia species seem to require more complex media.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030050304
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Decreased susceptibility of Malassezia furfur to UV light by synthesis of tryptophane derivatives (1998)
    Springer
    Antonie van Leeuwenhoek 73 (1998), S. 315-319 
    Details
    ISSN: 1572-9699
    Keywords: Malassezia furfur ; UV sensitivity ; Tryptophane-derived UV filter
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Recently, tryptophane (Trp)-dependent synthesis of pigments and fluorochromes in Malassezia furfur was described. The possible significance of this metabolic pathway for the microorganism remains to be explored. Since the upper parts of the human epidermis are a natural habitat of M. furfur, increased exposure to UV light may be hazardous. Five reference strains and one wild type strain of M. furfur were grown on m-Dixon agar, in which the nitrogen source peptone had been substituted either by pigment-inducing tryptophane or arginine. The yeast cells thus obtained were harvested after 6 days, washed with physiological saline and inoculated on to the modified Dixon medium. Immediately after inoculation, the yeast cells were irradiated with UVA (100, 150 and 200 Jcm-2, single dose) or UVB (100, 500, 1000, 1500, 2000 mJcm-2, single dose; 500, 1500, 2500 mJcm-2cumulative dose). Irrespective of the primary nitrogen source (Trp or Arg), unexposed controls showed nearly identical cell yield after 5 days. In the case of irradiation, however, growth reduction of cells cultured on Trp was lesser than that of cells fed with arginine. High significance (p〈0.0001) was found especially with the upper UVA and UVB doses. Differences were also found among the individual test strains, the wild strain being most sensitive. One strain (CBS 6094) failed to produce pigment on Trp medium, and there were no differences in the growth behavior of subcultures of this strain fed with either arginine or tryptophane under irradiation. In conclusion, synthesis of pigments and fluorochromes by M. furfur implies the generation of potent UV filters in the UVA and UVB spectrum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1001500310537
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Detection of extracellular phospholipase activity inCandida albicans andRhodotorula rubra (1996)
    Springer
    Mycopathologia 135 (1996), S. 149-155 
    Details
    ISSN: 1573-0832
    Keywords: Candida albicans ; phospholipases ; Rhodotorula rubra ; virulence factor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Phospholipases are important pathogenicity determinants inCandida albicans. They play a significant role in damaging cell membranes and invading host cells. High phospholipase production is correlated with an increased ability of adherence and a higher mortality rate in animal models. By means of an egg yolk-containing agar and thePz (= phospholipase activity zone) value according to Price, the present study investigated phospholipase production in 170 strains ofC. albicans. At an incubation temperature of 37 °C,Pz values ranged from 0.395 to 1; no clear relationship was found between clinical origin of the isolates and severity of the disease. In addition toC. albicans, a total of 110 strains of 16 other yeast species were investigated for possible phospholipase production. Only yeasts of the speciesRhodotorula rubra showed phospholipase activity, with mean values exceeding those observed inC. albicans. This result was confirmed by an assay using sterile culture filtrates and phosphatidyl-[3H-methyl]-choline-dipalmitoyl as a substrate. SinceRh. rubra has only rarely been demonstrated as a pathogen in humans, we believe that factors such as reduced growth at 37 °C, absence of dimorphism and low ability of adherence lessen the importance of high phospholipase activity inRh.rubra as a pathogenicity determinant. Therefore, potential virulence factors should always be considered in the context of the whole spectrum of pathogenic determinants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00632336
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...