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  • 1
    ISSN: 1360-0443
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin , Psychologie
    Notizen: Background  Previous published studies assessed the efficacy of bupropion in smoking cessation only in North American populations of smokers. Results of therapeutic drug trials are not always directly applicable in other populations.Aims  To confirm the efficacy of bupropion in smoking cessation in European smokers.Design  A multi-centre, randomized, double-blind placebo-controlled trial.Setting  Seventy-four smoking cessation out-patient clinics in France.Participants  The study included 509 smokers motivated to quit smoking.Intervention  Subjects were randomized to either slow-release bupropion 150 mg b.i.d. (B) or to placebo (Pl) in a 2 : 1 ratio, treated for 7 weeks, and followed-up for 26 weeks.Measurements  Main outcome measure: 6 months’ point prevalence abstinence, determined by self-report and expired air carbon monoxide measurement. Secondary outcome measures: weeks 4–7 and weeks 4–26 continuous abstinence rates, craving, withdrawal symptoms, weight and cigarette consumption in smokers unable to quit. Adverse events were recorded systematically.Findings  Six months’ point prevalence abstinence rates were 31% and 16%[odds ratio = 2.3, confidence interval (CI) 95%: 1.4–3.7] in the B and Pl groups, respectively. Continuous abstinence rates were 41% (B) and 21% (P) with OR = 2.5 (CI 95%: 1.6–3.9) for weeks 4–7, and 25% (B) and 13% (P) with OR = 2.2 (CI 95%: 1.3–3.6) for weeks 4–26, respectively. Craving decreased significantly more with B than with Pl during treatment period, but there was no difference for total withdrawal symptoms score. Abstinent subjects gained significantly less weight at week 7 with B than with Pl. Low level of nicotine dependence, high motivation, absence of smoking-related disease, long duration of previous quit attempts, male gender, low level of current alcohol problems and living as a couple were predictive of successful cessation. With the exception of marital status, no interaction was observed between any of these predictive factors and the efficacy of bupropion. More of those who continued smoking in the B group than the P group reduced their consumption by at least 50%.Conclusions  Sustained-release bupropion is efficacious as an aid to smoking cessation in European smokers. No outcome predictors were identified that might indicate that certain subgroups of smokers would benefit more than others from treatment with bupropion.
    Materialart: Digitale Medien
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  • 2
    Digitale Medien
    Digitale Medien
    Oxford UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 15 (2001), S. 0 
    ISSN: 1365-2036
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: : The relationship between Helicobacter pylori infection and non-ulcer dyspepsia is not established.〈section xml:id="abs1-2"〉〈title type="main"〉Aim: To determine whether eradication of H. pylori might be of benefit in non-ulcer dyspepsia patients.〈section xml:id="abs1-3"〉〈title type="main"〉Methods: We randomly assigned 129 H. pylori infected patients with severe epigastric pain, without gastro-oesophageal reflux symptoms, to receive twice daily treatment with 300 mg of ranitidine, 1000 mg of amoxicillin, and 500 mg of clarithromycin for 7 days and 124 such patients to receive identical-appearing placebos.〈section xml:id="abs1-4"〉〈title type="main"〉Results: Treatment was successful (decrease of symptoms at 12 months) in 62% of patients in the active-treatment group and in 60% of the placebo group (N.S.). At 12 months, the rate of eradication of H. pylori was 69% in the active-treatment group and 18% in the placebo group (P 〈 0.001). Complete relief of symptoms occurred significantly more frequently in patients on the active treatment (43%) than in placebo-treated patients (31%, P=0.048). Within the active-treatment group, therapeutic success was significantly more frequent in the non-infected patients (84% vs. 64%, P=0.04).〈section xml:id="abs1-5"〉〈title type="main"〉Conclusions: Although eradicating H. pylori is not likely to relieve symptoms in the majority of patients with non-ulcer dyspepsia, a small proportion of H. pylori-infected patients may benefit from eradication treatment.
    Materialart: Digitale Medien
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  • 3
    Digitale Medien
    Digitale Medien
    Springer
    Neuroradiology 38 (1996), S. 333-337 
    ISSN: 1432-1920
    Schlagwort(e): Spinal tumours ; Spinal cord compression ; Primary non ; Hodgkin's lymphoma ; Magnetic resonance imaging
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We examined eight patients with primary spinal epidural non-Hodgkin's lymphoma presenting with spinal cord compression and proven histologically after laminectomy (7 cases) or biopsy (1 case) by MRI. The most common findings were an isointense or low signal relative to the spinal cord on T1-weighted images (T1WI) and high signal on T2-weighted images (T2WI). Spinal cord compression, vertebral bone marrow and paravertebral extension were assessed. Contrast enhancement was intense in seven of the eight cases and homogeneous in all of them. T2WI (performed in 2 cases) may be useful to distinguish metastatic carcinomas and sarcomas. T1WI demonstrated the full extent of the epidural lesion, which was well-delineated in all cases. When the paravertebral extension is not well-defined, a study with contrast medium should be performed.
    Materialart: Digitale Medien
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  • 4
    Digitale Medien
    Digitale Medien
    Springer
    Neuroradiology 38 (1996), S. 333-337 
    ISSN: 1432-1920
    Schlagwort(e): Key words Spinal tumours ; Spinal cord compression ; Primary non-Hodgkin's lymphoma ; Magnetic resonance imaging
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We examined eight patients with primary spinal epidural non-Hodgkin's lymphoma presenting with spinal cord compression and proven histologically after laminectomy (7 cases) or biopsy (1 case) by MRI. The most common findings were an isointense or low signal relative to the spinal cord on T1-weighted images (T1WI) and high signal on T2-weighted images (T2WI). Spinal cord compression, vertebral bone marrow and paravertebral extension were assessed. Contrast enhancement was intense in seven of the eight cases and homogeneous in all of them. T2WI (performed in 2 cases) may be useful to distinguish metastatic carcinomas and sarcomas. T1WI demonstrated the full extent of the epidural lesion, which was well-delineated in all cases. When the paravertebral extension is not well-defined, a study with contrast medium should be performed.
    Materialart: Digitale Medien
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  • 5
    Digitale Medien
    Digitale Medien
    Springer
    Coral reefs 18 (1999), S. 179-186 
    ISSN: 1432-0975
    Schlagwort(e): Key words Coral ; Remote sensing ; Optical spectra ; Pigments
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Geologie und Paläontologie
    Notizen: Abstract  Coastal reef degradation and widespread bleaching of corals, i.e. loss of pigments and/or symbiotic zooxanthellae, is increasing globally. Remote sensing from boats, aircraft or satellites has great potential for assessing the extent of reef change, but will require ground-verified spectral algorithims characteristic of healthy and degraded reef populations. We collected seven species of Caribbean reef corals and also representative macroalgae from reefs near Lee Stocking Island, Bahamas and quantified their pigments using high performance liquid chromatography. We also measured the fluorescence and reflectance spectra of corals and macroalgae using an in situ benthic spectrofluorometer. In visibly pigmented (unbleached) coral from 4 to 5 m depth, the mean (±SD) surface density of pigments (3.0±1.3 μg chlorophyll-a cm-2 and 2.1±0.7 μg peridinin cm-2) was similar between colonies of the same species, but differed among species. The mean quantity of pigment per zooxanthella (1.8±0.9 pg chl-a cell-1 and 1.4±0.7 pg peridinin cell-1) also differed among species and sometimes between colonies of the same species. Chl-a and peridinin densities per surface area of coral were positively correlated. When excited with blue light (480 nm), macroalgae and corals had typical chlorophyll fluorescence with a peak at 680 nm and a smaller shoulder peak at 730 to 740 nm. Most corals, unlike macroalgae, also had distinct fluorescence peaks between 500 and 530 nm. In visibly bleached corals 680 nm fluorescence was greatly reduced in amplitude. Pigmented coral, under natural lighting conditions, had a reflected light peak at about 570 nm. Reflectance increased over all wavelengths in bleached corals, with the greatest increase at the wavelengths where chlorophyll and accessory pigments absorb light, i.e. 670 and 450 to 550 nm. Both fluorescence and reflectance spectra appear promising to remotely differentiate between pigmented and bleached coral and between coral and macroalgae.
    Materialart: Digitale Medien
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  • 6
    Digitale Medien
    Digitale Medien
    Springer
    European journal of orthopaedic surgery & traumatology 8 (1998), S. 27-36 
    ISSN: 1432-1068
    Schlagwort(e): Lumbar Spine ; Osteosynthesis ; FEA ; In vitro testing
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The present study is a numerical comparison using finite-element analysis (FEA) of two different concepts of spinal fixation devices when implanted. These implants are 1) the Easy®, “rigid” Screw/Rod (ø 6mm) system; 2) the Twinflex®, “dynamic” system (ø 2 X 2.5 mm ELF). A parameterised 3D FEA model of an L3-sacrum segment, developed by Lavaste, Skalli & Robin, was used. Geometric and mechanical models of each implant were then constructed, before being inserted in the spinal segment model. Then, for model validation, these two L3-S2 instrumented segmental models were submitted to similar boundary conditions as used in a previous in vitro comparison of the same implants. Flexion loaddisplacement curves were then controlled using experimental results. Loads acting on screws and longitudinal elements were calculated and analysed for a better understanding of the intrinsic differences between both constructs. Load-displacement responses of both constructs were quite similar (L3 sagittal rotation at 10 N.m = ~1.5°), while loads in the implant were not. For example, the axial push-in forces at the S1 screws were equal to 30 N for the Twinflex®, and 150 N for the Easy® Screw/Rod system. The pull-out forces at the S2 screws were respectively 100N and 200 N for the Twinflex and Screw/Rod Concept. At other levels, axial forces were all lower than 60 N, the Twinflex®, values being higher than the Easy® ones. Bending moments along screws were respectively 0.7 N.m and 1.4 N.m at the L3 level for the Twinflex® and the Easy® systems. At lower levels, values were all below 0.6 N.m, again with a reversed proportion. Bending moments calculated along longitudinal elements were always lower than 0.3 Nm for the Twinflex®, and up to 2 N.m for the Easy® system. Axial forces in the Twinflex® longitudinal elements were about 160 N, and about 100 N in the Easy® rods. Although the numerical approach mainly provides tendencies, it clearly seems that reducing flexural stiffness of lumbar fixation induces more homogeneous load transmission along the construct, and greatly reduces axial push-in/pull-out forces at the S1/S2 levels, and all this without reducing the rigidity of the whole construct. Conversely, it has been shown that “rigid” longitudinal elements may concentrate stresses at the construct extremities, relieving loads at intermediate levels at the same time, which may be the sign of a stress-shielding-like phenomenon. These differences arise from a fundamental difference between both kinds of longitudinal elements in the way they transmit loads. The ø 6 mm rods mainly oppose a bending reaction torque to the applied flexion moment, whereas the Twinflex® construct mainly balances the applied flexion torque by an anterior compression of the anterior column, combined with posterior traction on its longitudinal elements (ELF).
    Materialart: Digitale Medien
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  • 7
    Digitale Medien
    Digitale Medien
    Springer
    European journal of orthopaedic surgery & traumatology 8 (1998), S. 171-174 
    ISSN: 1432-1068
    Schlagwort(e): Arthrography ; Second hip arthrography ; Hip aspiration ; Infection
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The aim of that study was to evaluate the place of arthrography for component loosening and of hip aspiration for diagnosing infection. 52 arthrograms were done under local anesthesia in radiology suites under fluoroscopic guidance. If no fluid was aspirated a non bacteriostatic saline solution was injected and reaspirated. Liquid was then analized. Component loosening was evaluated by plain films and by arthrography and compared to the surgical findings in all cases. The sensitivity of arthrography (94.5%) was better than that of plain films (83%) for evaluating socket loosening, but was worse (77%vs 92%) for femoral component evaluation. They were no false positive evaluations in socket loosening, but false negatives occurred in 2 cases with supporting material such as screws and plates. Results for femoral loosening are more difficult to analyse. The sensitivity (77%) and the specificity (81%) of arthrography are lower than plain films (92% and 88%). Most authors consider that the femoral component is loose when more than one third of the stem has a lucent line. 4 patients had such findings and were operated on. In each case the stem was found to be stable at operation. We removed the stem in two cases and left it in place in two old patients. We simply cleaned the granuloma from the proximal part of the femur. It means that arthrography did not really fail to make the diagnosis. But surgical procedures in case of incomplete radiolucent lines are not mandatory and depend on the individual surgeon's philosophy. Sensitivity of hip aspiration to identify periprosthetic germ was 66% and a specificity was 100%. No false positives were found. Only one patient over 41 without any sign of active infection had a positive hip aspiration. This test is not sensitive enough to be a prerequiste test before total hip revision but has to be done in cases of clinical or suspected sepsis.
    Materialart: Digitale Medien
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  • 8
    Digitale Medien
    Digitale Medien
    Springer
    European journal of orthopaedic surgery & traumatology 9 (1999), S. 135-149 
    ISSN: 1432-1068
    Schlagwort(e): Lumbar spine ; Narrowing ; Stenosis ; Surgery
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Orthopedic surgeons and neurosurgeons gathered in Paris on January 29 for the third annual meeting of the ARGOS association, presided over by Dr. Christian Mazel from the Montsouris Medical Center (IMM Site Choisy) in Paris, Prof. Pierre Kehr of the Strasbourg-Illkirch Center of Traumatology and Orthopedics (CTO), and Dr. Jean-Paul Forthomme from the Saint-Joseph Clinic in Mons (Belgium). The day focused on the theme of lumbar canal stenosis. From its diagnosis to the choice of surgical technique — root canal enlargement, laminectomy, or other — or the role played by arthrodesis, this vast subject allowed substantial room for debate. We present here a synopsis of the day.
    Materialart: Digitale Medien
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