ISSN:
1619-7089
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Following a study of the main factors involved in the 68-Ga labelling of human serum albumin microspheres (H.S.A.M.), especially methods of production and preparation of active solution and conditions of radioelement fixation on the protein support, the practical details of a fast technique (60 min) based on the process described by Hnatowich are presented. This method gives high labelling yields (93±3%), and after washing of the microspheres leads to a radiopharmaceutical product almost without free68Ga (less than 2%). The spheres ready for use carry a total radioactivity corresponding to about 35%, including decay, of the activity originally recovered in the generator eluate and to more than 98% of that, found in the final suspension. The labelled product is sterile, non-pyrogenic and non-toxic. When it is injected in animals by left ventricle catheterization the uptake rates in the heart, lungs, spleen, left kidney and right kidney are similar to those observed with reference85Sr-labelled carbonized microspheres. This radiopharmaceutical, casy to prepared and having excellent biological and nuclear properties, seems ideally suited for the scanning of organs by positron emission tomoscintig raphy.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00626078
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