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  • 1
    Electronic Resource
    Electronic Resource
    D-Cycloserine enhances social behaviour in individually-housed mice in the resident-intruder test (1994)
    Springer
    Psychopharmacology 116 (1994), S. 317-325 
    Details
    ISSN: 1432-2072
    Keywords: D-Cycloserine ; Strychnine-insensitive glycine site ; GABA ; Social behaviour ; Mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract D-Cycloserine (DCS) has been reported to affect the central nervous system in man. To investigate whether the compound produces specific behavioural effects, DCS was administered to male mice in a resident-intruder situation and the behaviour of the interacting mice assessed using ethological analysis. Resident mice given DCS (32.0–320.0 mg/kg PO, 60 min before testing) showed dose-dependent increases in social investigation, smaller increases in sexual behaviour and decreased aggressiveness. Defensive and flight behaviour were not affected. Intruder mice showed slight increases in sexual behaviour that were not dose-dependent, and small increases in social investigation. The increases in social investigation induced by DCS (320.0 mg/kg) in resident mice were not reversible with R-HA 966 (32.0 mg/kg IP, 30 min before testing), a blocker of the strychnine-insensitive glycine modulatory site associated with theN-methyl-D-aspartate receptor, but were blocked by the GABA antagonist bicuculline (0.56 mg/kg IP, 5 min before testing). The small DCS-induced increase in sexual behaviour in residents was reversed by R-HA 966. Within the parameters of the resident-intruder situation, DCS exerts socio-sexual behaviour-enhancing effects which are dependent upon the role of the interactant, and which are mediated by an action upon multiple substrates. DCS may be regarded as another example of a sociotropic (approach-promoting) agent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02245335
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  • 2
    Electronic Resource
    Electronic Resource
    A single administration of d-amphetamine prior to stimulus pre-exposure and conditioning attenuates latent inhibition (1997)
    Springer
    Psychopharmacology 130 (1997), S. 79-84 
    Details
    ISSN: 1432-2072
    Keywords: Key words Latent inhibition ; Conditioned emotional response ; Amphetamine ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of a single administration of d-amphetamine (0.32 mg/kg, SC) upon latent inhibition (LI) in a one-session pre-exposure and conditioning procedure was investigated in rats in a conditioned emotional response paradigm. It was found that amphetamine attenuated LI. The effects could not be attributed to differences in unconditioned suppression nor to differences in response rates between the experimental groups. These results support the observations of Dunn and suggest that the disruption of LI may not depend upon a complex interaction between changes in neuronal processes consequent upon repetitive amphetamine administration and the schedule with which the drug is administered during the experimental procedure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002130050213
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    A time-activity baseline to measure pharmacological and non-pharmacological manipulations of PCP-induced activity in mice (1997)
    Springer
    Psychopharmacology 134 (1997), S. 157-163 
    Details
    ISSN: 1432-2072
    Keywords: Key words Phencyclidine (PCP) ; Locomotion ; Ataxia ; Time ; Haloperidol ; Chlordiazepoxide ; Pentobarbital ; Mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract At critical doses of PCP (10 mg/kg IP in the present studies), locomotor stimulation in mice is initially suppressed by short-lasting ataxia, albeit at higher levels of activity than controls. This provides a time-activity baseline of PCP-stimulated locomotion potentially sensitive to i) pharmacological antagonism indicated by a change in the time-activity relationship to that seen at lower PCP doses, ii) interaction with the ataxic phase resulting in further decreases in activity similar to that seen at higher PCP doses and iii) reductions in activity without a change in the time-activity relationship. This baseline was explored using three manipulations employed in the clinical management of PCP toxicity: treatment with a neuroleptic (haloperidol), a benzodiazepine (chlordiazepoxide) and modification in environmental stimulation (changing of lighting conditions). Both haloperidol (0.125–0.5 mg/ kg, IP) and chlordiazepoxide (5–20 mg/kg IP) further reduced activity during the ataxic phase of the PCP time-activity relationship qualitatively similar to the effects of pentobarbital (20–40 mg/kg IP). Changing of lighting conditions from red to white light resulted in significant reductions in levels of activity of PCP-treated animals but no change in the time-activity relationship. No manipulation resulted in true reversal of the PCP induced time-activity relationship. The results parallel the clinical findings that neuroleptic and benzodiazepine administration have no specific effects upon PCP-intoxication and that environmental manipulation may modify the degree of PCP stimulation. The time-activity baseline described may prove useful in the evaluation of the effects of pharmacological and non-pharmacological manipulations of PCP-induced activity in rodents.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002130050437
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The acetylcholinesterase inhibitor, ENA 713 (Exelon), attenuates the working memory impairment induced by scopolamine in an operant DNMTP task in rats (1999)
    Springer
    Psychopharmacology 146 (1999), S. 10-18 
    Details
    ISSN: 1432-2072
    Keywords: Key words Delayed non-matching to position task ; Scopolamine ; ENA 713 ; Exelon ; Working memory ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract   Rationale: The disruption of working memory in the delayed non-matching to position (DNMTP) task by the muscarinic antagonist, scopolamine, is considered to be a model of the spatial working memory deficit in Alzheimer’s disease (AD) patients. Objective: To investigate whether ENA 713 (Exelon) (0.1, 0.5 mg/kg, IP), an acetylcholinesterase inhibitor, would reverse the effects of scopolamine in the DNMTP task. Methods: Male Lister Hooded rats were trained to criterion in an operant DNMTP task (0- to 16-s delay intervals) before receiving vehicle, scopolamine (0.05 mg/kg, SC) alone, ENA 713 (0.1, 0.5 mg/kg, IP) alone, or combinations of scopolamine and ENA 713, in two variations of the task – with and without barriers inserted between the food magazine and the two levers. Barriers were inserted to prevent the use of positional strategies to perform the task, since this behaviour may confound the conclusions of the effect of drugs on working memory. Results: It was found that: (i) scopolamine significantly reduced choice accuracy delay-dependently in both test situations while modifying non-mnemonic measures of task performance delay-independently, indicating an impairment of working memory; (ii) ENA 713 (0.5 mg/kg) significantly attenuated the scopolamine-induced impairment of working memory and significantly reduced the scopolamine-induced changes in some non-mnemonic measures of task performance; (iii) the presence of barriers did not alter the effects of scopolamine and ENA 713 on working memory. Conclusion: ENA 713 reversed the working memory deficit induced by scopolamine. These results are consistent with the attenuation of learning and memory disruptions due to cholinergic dysfunction by ENA 713 in other preclinical assays, and predict a drug-induced improvement in working memory in AD patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002130051082
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Comparison in the mouse of the effect of the opiate delta receptor antagonist ICI 154 129 and naloxone in tests of extinction, passive avoidance and food intake (1983)
    Springer
    Psychopharmacology 82 (1983), S. 41-45 
    Details
    ISSN: 1432-2072
    Keywords: Opiate delta receptor ; Naloxone ; ICI 154 129 ; Extinction ; Food intake ; Passive avoidance ; Mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of 30 and 80 mg/kg ICI 154 129, an opiate delta receptor antagonist, were compared with those of 0.1 and 10 mg/kg naloxone using tests of food-intake, passive avoidance and extinction in mice. Whereas anloxone depressed food intake and facilitated extinction, ICI 154 129 failed to affect food intake, passive avoidance or extinction although the mice reared significantly more during the test of food intake.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426378
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    Paper (German National Licenses)
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