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  • 1
    Electronic Resource
    Electronic Resource
    Rapid detection of mutations by conformation-sensitive gel electrophoresis. Application to the identification of a fourth family with the Arg^5^1^9-〉Cys substitution and three new mutations in the type II procollagen gene
    Amsterdam : Elsevier
    Matrix Biology 14 (1994), S. 391 
    Details
    ISSN: 0945-053X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0945-053X(94)90114-7
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  • 2
    Electronic Resource
    Electronic Resource
    Resource partitioning by three species of hemipteran herbivores on the basis of host plant density (1981)
    Springer
    Oecologia 48 (1981), S. 414-417 
    Details
    ISSN: 1432-1939
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Three hemipteran herbivores partition a common resource plant, Senecio smallii, on the basis of bud density and plant patch size. The monophagous herbivore, Neacoryphus bicrucis, is most abundant in larger patches where bud density is greatest. The oligophagous herbivore, Harmostes reflexulus, is most abundant in small patches of high bud density. The polyphagous species, Lygus pratensis, is most abundant in small patches where abundance is independent of bud density. The aggressive nature of the monophagous herbivore appears to mediate the responses of the other species.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00346503
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  • 3
    Electronic Resource
    Electronic Resource
    Amifostine: potential for clinically useful cytoprotection (1994)
    Springer
    Supportive care in cancer 2 (1994), S. 380-384 
    Details
    ISSN: 1433-7339
    Keywords: Amifostine ; WR-2721 ; Cytoprotection ; Myelosuppression ; Radioprotection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The ability to target malignant cells for cytotoxicity while sparing normal host tissues has proven to be limited. These limitations have resulted in unacceptable toxicity or insufficiently effective therapy. Continuing investigation of new, potentially useful cytotoxic agents must continue. An alternative approach, also worthy of study, is the selective protection of normal tissues. This approach, used in conjunction with available therapeutic agents, may open the therapeutic window and incrementally enhance the effectiveness of cytotoxic therapy. A variety of methods have been used to protect normal tissues selectively. Regional protection can be used for certain organ systems, such as the oral mucosa. Selective protection on a systemic level is more difficult but agents that seem to protect normal but not malignant tissues selectively are being developed. Among these is amifostine, which was originally selected by the U.S. defense department for study as a radio-protectant. Pre-clinical studies have suggested that amifostine is differentially concentrated in normal tissues but not in malignant tissues. Tissue-specific differences in the activity of alkaline phosphatase, which dephosphorylates amifostine to its active metabolite WR-1065, and in pH are thought to be involved in this relative specificity. Clinical studies indicate that amifostine can reduce the myelosuppression produced by cyclophosphamide, the combination of cyclophosphamide and cisplatin, and, perhaps, carboplatin. The protective effects of amifostine on non-hematopoietic toxicities are being investigated. Future trials will investigate the integration of amifostine with cytokine-based supportive care in order to define the role of this potentially clinically useful cytoprotectant agent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00344052
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  • 4
    Electronic Resource
    Electronic Resource
    A phase I trial of intrapleural recombinant human interferon α (rHuIFNα2b) in patients with malignant pleural effusions (1994)
    Springer
    Journal of cancer research and clinical oncology 120 (1994), S. 169-172 
    Details
    ISSN: 1432-1335
    Keywords: Intrapleural ; Phase I ; rHuIFNα2b
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The use of intrapleural sclerosing agents to control reaccumulation of pleural fluid in patients with malignant effusions has been widely investigated. A phase I trial of intrapleural recombinant human interferon α (rHuIFNα2b) was initiated to determine the toxicity and maximal tolerated dose in this group of patients. rHuIFNα2b was instilled as a single dose following chest tube (15/16) or percutaneous (1/16) drainage of cytologically proven malignant effusions. Doses of rHuIFNα2b were escalated from 25×106 to 200×106 U/m2 in cohorts of three to four patients. Toxicity was mild to moderate, and included chills, fever and chest pain, and resembled that produced by systemic administration of rHuIFNα2b. Dose-limiting toxicity occurred at 200×106 U/m2 and consisted of hepatic enzyme elevations and renal failure. Partial control of the effusions was noted in two patients, with two additional patients having stable disease. Phase II trials of rHuIFNα2b should utilize up to 150×106 U/m2 for intrapleural instillation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01202197
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  • 5
    Electronic Resource
    Electronic Resource
    Interspecific interference competition and mate choice in the soldier beetle, Chauliognathus pennsylvanicus (1981)
    Springer
    Behavioral ecology and sociobiology 9 (1981), S. 65-66 
    Details
    ISSN: 1432-0762
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Interference competition directed at soldier beetles, Chauliognathus pennsylvanicus, by four aggressive wasp species changed the mate choice of females. In the absence of wasps, females mated more frequently with males of greater weight and greater antennal scape diameter. Only in the presence of wasps did females frequently mate when they did not contain mature ova. When wasps were abundant, the proportion of beetles mating was higher. Wasps reacted aggressively toward mating beetles less frequently than toward single beetles. Therefore, females may have fed more efficiently in the presence of wasps when coupled.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00299855
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  • 6
    Electronic Resource
    Electronic Resource
    Phase II Trial of Liposomal Doxorubicin (Doxil®) in Advanced Soft Tissue Sarcomas (2000)
    Springer
    Investigational new drugs 18 (2000), S. 253-259 
    Details
    ISSN: 1573-0646
    Keywords: liposomal doxorubicin ; liposome ; sarcoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Purpose: To assess the objective response rate, toxicityexperienced, progression-free survival, and overall survival ofpatients with previously untreated advanced soft tissue sarcomastreated with a liposomal doxorubicin formulation (Doxil). Methods: Patients with metastatic or recurrent soft tissuesarcoma who had received no prior chemotherapy for advanceddisease were treated with liposomal doxorubicin (Doxil) accordingto a two stage accrual design. Doxil was administered at 50mg/m2 every 4 weeks. A total of 15 patients were treated andare evaluable for response and toxicity. Results: The male/female ratio was 7/8, the median age was60 years (34–75) and the ECOG performance status was 0-1 in〉90% of patients. Leiomyosarcoma (7/15) and malignant fibroushistiocytoma (2/15) were the most common histologic diagnoses.No objective responses were observed in the 15 evaluablepatients. No lethal toxicity occurred. Grade 3–4 leukopenia orneutropenia were reported in 3/15 (20%) patients. Grade 3mucositis or hand-foot syndrome occurred in 2/15 (13%) and 1/15(7%) patients respectively and seemed more severe in olderpatients. The median time to progression was 1.9 months (range0.9–6.2). Twelve patients have now died. The Kaplan-Meierestimate of median overall survival is 12.3 months. As called forin the study design, accrual was terminated because no responseswere obtained in the first 15 patients. Conclusion: Though well-tolerated, Doxil given accordingto this dose and schedule to patients with advanced soft tissuesarcoma had no significant therapeutic activity. A correlationbetween older age and skin/mucosal toxicity of Doxil is suggestedin this study but needs confirmation. Future investigations ofDoxil in soft tissue sarcomas should use a different schedule anddose.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006429907449
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  • 7
    Electronic Resource
    Electronic Resource
    More on the cold eddy south of Enshunada: Evidence of an approximate 3°c increase in mean sea surface temperature sometime between 1941 and 1949 (1972)
    Springer
    Journal of oceanography 28 (1972), S. 254-259 
    Details
    ISSN: 1573-868X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract Although February mean sea surface temperatures at Hachijojima indicate no long-term trends from 1926 to 1970, historical data from 1901 to 1967 (over 100,000 observations) from ships-of-opportunity in the area south of Enshunada indicate an abrupt increase of approximately 3°C in both February and annual mean sea surface temperatures sometime between 1941 and 1949, possibly in 1942. This change is considered to be too large to be the result of differences that might have occurred in observational methods, and heat budget calculations indicate that surface cooling should have occurred. Cause for the increase is unexplained at this time.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02109295
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