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  • 1
    Electronic Resource
    Electronic Resource
    Conformations of glycyl-trans-4-fluoro-L-prolyl-L-tryptophan in aqueous solution (1976)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 98 (1976), S. 3970-3975 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00429a037
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  • 2
    Electronic Resource
    Electronic Resource
    Conformations of cis- and trans-4-fluoro-Yl-proline in aqueous solution (1973)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 95 (1973), S. 5725-5729 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00798a046
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  • 3
    Electronic Resource
    Electronic Resource
    Attempted synthesis of 2-methylalanyl-L-prolyl-L-tryptophan. An unexpected result (1976)
    s.l. : American Chemical Society
    The @journal of organic chemistry 41 (1976), S. 1653-1655 
    Details
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jo00871a042
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  • 4
    Electronic Resource
    Electronic Resource
    Emergency colectomy in colitis (1989)
    Springer
    International journal of colorectal disease 4 (1989), S. 200-203 
    Details
    ISSN: 1432-1262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Conclusion While the overall morbidity and mortality of ulcerative colitis is low, toxic megacolon poses a challenge to even the most experienced gastrointestinal surgeon. To optimize results, patients require careful and frequent assessment, and vigorous preoperative resuscitation. Surgery must be performed carefully with the goal of improving the patient's overall well-being. In most instances, this means that a definitive surgical procedure is not performed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01649704
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  • 5
    Electronic Resource
    Electronic Resource
    Improved results following use of an advancement technique in the treatment of ileoanal anastomotic complications (1988)
    Springer
    International journal of colorectal disease 3 (1988), S. 161-165 
    Details
    ISSN: 1432-1262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Between December 1981 and March, 1987, 188 ileal reservoir and ileoanal anastomosis procedures were performed at the University of Toronto. Anal anastomotic complications occurred in 24 (12.8%) patients. There were 19 patients who developed a leak as a result of non-healing of the ileoanal anastomosis (group 1). Late fistulae occurred in 5 patients (group 2). Various treatments were employed. In group 1, 2 of 15 (13%) patients treated with drainage and antibiotics, 3 of 7 (43%) in whom the anastomosis was resutured, and 5 of 7 (71%) in whom repair was performed by advancing the ileal outlet and resuturing the anastomosis, healed their anastomosis. One patient was treated successfully by performing a fistulotomy. Treatment was unsuccessful in one patient in whom the ileal reservoir and ileoanal anastomosis were revised and re-anastomosed. One patient (50%) in group 2 was treated successfully by advancing the ileal outlet and resuturing the anastomosis. Complete healing of the anastomosis was achieved in 12 patients (50%), although 3 patients subsequently required excision of the reservoir because of inability to evacuate spontaneously (1), incontinence (1), or psychological reasons (1). All nine (38%) patients who were functioning with their ileal reservoir were continent. One patient intubated the reservoir. The rate of urgency and soiling, and the number of bowel movements per 24 hours did not differ significantly from those of patients without these anastomotic complications. Our results suggest that early diagnosis and repair of ileoanal anastomotic dehiscence by advancement of the ileal outlet and resuturing of the ileoanal anastomosis results in improved reservoir salvage and satisfactory functional results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01648360
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  • 6
    Electronic Resource
    Electronic Resource
    Pelvic pouch emptying scan: an evaluation of scintigraphic assessment of the neorectum (1991)
    Springer
    International journal of colorectal disease 6 (1991), S. 29-32 
    Details
    ISSN: 1432-1262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Bien que l'étude scintigraphique de la vidange des poches pelviennes ait été utilisée pour évaluer la fonction du néorectum chez les patients qui ont subi une colectomie ou une proctectomie muqueuse et une anastomose iléo-anale avec réservoir, les études précédentes n'ont pas étudié la valeur de ce test pour mesurer le volume de la poche et sa vidange. Cette étude a donc été entreprise pour déterminer: (1) la valeur de la méthode chez les patients avec un résultat fonctionnel stable: (2) si une vidange fractionnée est corrélée avec le volume de la poche. 10 patients ayant un résultat fonctionnel stable ont eu à deux reprises à une semaine d'intervalle une scintigraphie au technecium 99. Le volume moyen des selles artifielles instillées était de 338±104 CC. La différence moyenne de volume instillé entre le premier et le deuxième scan était de 78±26 CC et la différence moyenne absolue du pourcentage évacué était de 12±9%. Cette différence entre les deux examens n'était pas statistiquement significative (p〉0.05). Il n'y avait pas de corrélation significative entre le volume des selles artificielles instillées dans la poche pelvienne et la fraction spontanément évacuée (r=-0.1). Le résultat suggère que la scintigraphie au technécium 99 de la vidange d'une poche pelvienne est valable chez les patients qui ont un résultat fonctionnel stable. La quantité de matières évacuée est indépendante du volume de la poche.
    Notes: Abstract Although scintigraphic pelvic pouch emptying scans have been used to evaluate neorectal function in patients who have undergone colectomy, mucosal proctectomy, and ileoanal pouch anastomosis, previous reports have not documented the reliability of this test in measuring pouch volume and emptying. Thus, this study was undertaken to determine: (1) the reliability of this test in patients with stable functional results and, (2) whether the emptying fraction correlates with the volume of the pouch. Ten patients who had stable functional results had 99m Tc-sulphur colloid pouch emptying scans performed on two occasions, one week apart. The average volume of artificial stool that was instilled was 338±104 cc. The mean difference in the volume instilled between the initial and repeat scans was 78±26 cc and the mean absolute difference in the percentage evacuated was 12±9 percent. These inter-test differences were not statistically significant (p〉0.05). There was no correlation between the volume of artificial stool instilled into the pelvic pouch and the fraction spontaneously emptied (r=-0.1). Our results suggest that the 99m Tc-sulphur colloid pelvic pouch emptying scan is reliable in patients with stable functional results. Pouch emptying fraction is independent of pouch volume.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00703957
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  • 7
    Electronic Resource
    Electronic Resource
    Ileal pouch-anal anastomosis: pregnancy, delivery and pouch function (1996)
    Springer
    International journal of colorectal disease 11 (1996), S. 84-87 
    Details
    ISSN: 1432-1262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé But: Evaluer les grossesses, accouchements et résultats fonctionnels de patients qui ont subi la confection d'une poche iléo-anale.Moyen: Une étude rétrospective avec questionnaire.Lieu: L'étude a été menée dans un hôpital universitaire.Sujet: Douze femmes qui avalient subi la confection d'une poche iléo-anale dans le centre des maladies inflammatoires du Mount Sinai Hospital et qui par la suite étaient devenues enceites ont été identifiées à partir des documents de l'hôpital. Un questionnaire de suivi a été complété par tous les sujets.Résultats: Douze patientes ont mené à terme 16 grossesses qui se sont terminées par 10 accouchements et 6 césariennes. Aucune complication n'est à déplorer en relation avec la poche au cours des 16 grossesses et deux complications sont survenues dans les suites des accouchements.Conclusion: Une grossesse peut être menée à terme de manière sûre chez des femmes porteuses d'une poche iléo-anale. Des résultats fonctionnels sont altérés au minimum. L'accouchement est sûr et seules des raisons obstétricales doivent être anvisagées pour réaliser une césarienne.
    Notes: Abstract Objective: To evaluate the pregnancies, deliveries and functional results of patients who have undergone and ileal pouch-anal anastomosis.Design: A retrospective survey by questionnaire.Setting: The study was conducted at a university hospital.Subjects: Twelve women who had undergone an ileal pouch-anal anastomosis at the Inflammatory Bowel Disease Centre, Mount Sinai Hospital and who had subsequently become pregnant, were identified from the hospital records. A follow up questionnaire was completed by all subjects.Results: Twelve patients had 16 deliveries. There were 10 vaginal deliveries and 6 caesarian sections. There were no pouchrelated complication during the 16 pregnancies and there were two postpartum complications.Conclusions: Pregnancy is safe in women with an ileal pouch-anal anastomosis. Functional results are altered minimally. Vaginal delivery is safe and obstetric reasons should determine whether a caesarian section is performed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00342465
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  • 8
    Electronic Resource
    Electronic Resource
    Ileal pouch-anal anastomosis: pregnancy, delivery and pouch function (1996)
    Springer
    International journal of colorectal disease 11 (1996), S. 84-87 
    Details
    ISSN: 1432-1262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé. But: Evaluer les grossesses, accouchements et résultats fonctionnels de patients qui ont subi la confection d'une poche iléo-anale. Moyen: Une étude rétrospective avec questionnaire. Lieu: L'étude a été menée dans un hôpital universitaire. Sujet: Douze femmes qui avalient subi la confection d'une poche iléo-anale dans le centre des maladies inflammatoires du Mount Sinai Hospital et qui par la suite étaient devenues enceintes ont été identifiées à partir des documents de l'hôpital. Un questionnaire de suivi a été complété par tous les sujets. Résultats: Douze patientes ont menéà terme 16 grossesses qui se sont terminées par 10 accouchements et 6 césariennes. Aucune complication n'est à déplorer en relation avec la poche au cours des 16 grossesses et deux complications sont survenues dans les suites des accouchements. Conclusion: Une grossesse peut être menée à terme de manière sûre chez des femmes porteuses d'une poche iléo-anale. Des résultats fonctionnels sont altérés au minimum. L'accouchement est sûr et seules des raisons obstétricales doivent être anvisagées pour réaliser une césarienne.
    Notes: Abstract. Objective: To evaluate the pregnancies, deliveries and functional results of patients who have undergone and ileal pouch-anal anastomosis. Design: A retrospective survey by questionnaire. Setting: The study was conducted at a university hospital. Subjects: Twelve women who had undergone an ileal pouch-anal anastomosis at the Inflammatory Bowel Disease Centre, Mount Sinai Hospital and who had subsequently become pregnant, were identified from the hospital records. A follow up questionnaire was completed by all subjects. Results: Twelve patients had 16 deliveries. There were 10 vaginal deliveries and 6 caesarian sections. There were no pouch-related complication during the 16 pregnancies and there were two postpartum complications. Conclusions: Pregnancy is safe in women with an ileal pouch-anal anastomosis. Functional results are altered minimally. Vaginal delivery is safe and obstetric reasons should determine whether a caesarian section is performed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003840050026
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  • 9
    Electronic Resource
    Electronic Resource
    Operative and environmental risk factors for recurrence of Crohn’s disease (1999)
    Springer
    International journal of colorectal disease 14 (1999), S. 224-226 
    Details
    ISSN: 1432-1262
    Keywords: Key words Crohn’s disease ; Anastomosis ; Risk factors ; Stapled ; Hand-sewn
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  This retrospective study determined whether a hand-sewn or stapled anastomosis leads to a greater recurrence rate in patients undergoing ileocecal resection for terminal ileal Crohn’s disease. The effects of oral contraceptive use, smoking, and age at onset of disease were also examined. Ninety-two patients with Crohn’s disease of the terminal ileum whose first operation was an ileocecal resection (terminal ileum and right colon up to but not including the hepatic flexure) were studied for symptomatic and operative recurrence. The symptomatic recurrence rates were 15% at 1 year, 31% at 2 years, and 45% at 3 years. The operative recurrence rates were 6% at 1 year, 14% at 2 years, and 22% at 3 years. The type of anastomosis, whether hand-sewn or stapled, did not affect the rates of symptomatic (P=0.3) or operative (P=0.6) recurrence. After the initial resection smoking affected both symptomatic (P=0.03, risk ratio=2.380) and operative (P=0.041, risk ratio=3.13) recurrence, but there was no effect of age at onset of disease or use of the birth control pill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003840050215
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  • 10
    Electronic Resource
    Electronic Resource
    Crohn's disease and pregnancy (1990)
    Springer
    Diseases of the colon & rectum 33 (1990), S. 869-873 
    Details
    ISSN: 1530-0358
    Keywords: Crohn's disease ; Pregnancy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Seventy-eight pregnancies in 50 patients were reviewed to evaluate the effects of Crohn's disease on the outcome of pregnancy and the influence of the pregnancy on the course of Crohn's disease. Overall, 21 pregnancies (27 percent) had abnormal outcomes including spontaneous abortions (9), infants small for gestational age (6), premature infants (5), and infants who developed respiratory distress (1). Eight (50 percent) patients with active disease compared with 13 (21 percent) patients with inactive disease at conception had abnormal outcomes (P 〈0.05). During pregnancy 15 (55 percent) with active disease and 6 (12 percent) with inactive disease had an abnormal outcome (P 〈0.001). Neither medical nor surgical treatment, independent of disease activity, appeared to affect the outcome adversely. Eighteen of 73 (25 percent) patients with quiescent or mild disease relapsed, and seven of 16 patients with some disease activity improved (44 percent). Of 34 patients on medication, nine relapsed (27 percent), and of 39 patients not on medication, nine relapsed (24 percent) (P=N.S.). These results suggest that the outcome of pregnancy is not adversely affected by Crohn's disease. However, patients with active disease at conception and/or during the pregnancy have poorer outcomes independent of the use of medication or requirement of surgery. Neither pregnancy nor medications taken affect the course of the disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02051924
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