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  • 1
    Digitale Medien
    Digitale Medien
    Paracoccidioidomycosis in nude mice: Presence of filamentous forms of the fungus (1988)
    Springer
    Mycopathologia 101 (1988), S. 3-11 
    Details
    ISSN: 1573-0832
    Schlagwort(e): Paracoccidioides brasiliensis ; nude mice ; hyphal forms
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract Congenitally athymic nude mice (nu/nu) and their phenotypically normal littermates (nu/+) were intraperitoneally infected with yeast cells of a strain of Paracoccidioides brasiliensis. The nude mice developed a severe and generalized infection with an intense parasitism of several organs, accompanied by a low-grade of tissue reaction. The lesions were characterized by abundant yeast-like cells of the fungus, and in some animals, numerous hyphal forms could be well visualized. In control animals, infection was moderate, almost exclusively restricted to the area of inoculation, and the lesions presented few parasites surrounded by an inflammatory response. Filamentous forms of the fungus were never encountered in these animals.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00455663
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Inoculation experimental animals withParacoccidioides brasiliensis strains: An attempt to reestablish the dimorphic process and variation in pathogenicity as a function of time of preservation under mineral oil (1996)
    Springer
    Mycopathologia 133 (1996), S. 135-138 
    Details
    ISSN: 1573-0832
    Schlagwort(e): Paracoccidioides brasiliensis ; Inoculation experimental ; Variation in pathogenicity ; Dimorphism ; Preservation in oil
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract In an attempt to reestablish the dimorphic process in strains ofParacoccidioides brasiliensis in the transition phase (Y ⇄ M) and to reisolate them, five strains in the transitional phase due to the long time of preservation under mineral oil and two strains in the yeast-like phase were inoculated into male albino rats. The animals were then studied for the presence of paracoccidioidomycotic granulomata. Of the seven strains inoculated, five caused granulomatous nodules in several organs of the animals and only two of these five strains, which had been preserved for the shortest period of time (9 years) were reisolated in culture. Two strains were unable to provoke infection, with no lesions detected in any organ. It is assumed that the long period of time during which the strains were left under oil favored the alteration of celt wall contents, leading to differences in pathogenicity.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02373019
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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