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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 32 (1987), S. 309-311 
    ISSN: 1432-1041
    Keywords: digoxin ; verapamil ; cirrhosis ; drug interaction ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The influence of a single low dose of verapamil (80 mg) on the serum levels of digoxin (single dose of 0.5 mg) was studied in 6 patients with hepatic cirrhosis and in 6 healthy volunteer controls. In the cirrhotic patients verapamil increased the peak serum level and the total AUC of digoxin by 98% and 32%, respectively. There was an associated 23% decrease in the renal digoxin clearance. In normal subjects only marginal alterations in digoxin kinetics were observed following verapamil administration. The results indicate that cirrhosis magnifies the influence of verapamil on digoxin kinetics.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 6 (1973), S. 61-63 
    ISSN: 1432-1041
    Keywords: Diazepam ; cardiac catheterization ; mitral valve disease ; haemodynamics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The haemodynamic effects of an intravenous infusion of diazepam (0.027 mg/kg/min i.v. for fifteen minutes) were studied in seven subjects with mitral valve disease during diagnostic cardiac catheterization. Diazepam produced a statistically significant decrease in arterial pressure in the pulmonary artery and aorta, and a fall in the heart rate. Cardiac output and the calculated peripheral and pulmonary resistances also changed, but not in a consistent manner, and the differences were not statistically significant. Oxygen saturation in the aorta and pulmonary artery was not affected.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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