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  • 1
    Electronic Resource
    Electronic Resource
    Prognostic relevance of cathepsin D detection in micrometastatic cells in the bone marrow of patients with primary breast cancer (1998)
    Springer
    Breast cancer research and treatment 49 (1998), S. 145-154 
    Details
    ISSN: 1573-7217
    Keywords: tumour cell detection ; cathepsin D ; breast cancer ; micrometastasis ; prognostic factor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Patients with an elevated level of cathepsin D in breast cancer tissue have an adverse prognosis. This study evaluated the prognostic relevance of cathepsin D detection in disseminated tumour cells in bone marrow. Bone marrow was sampled intraoperatively from both anterior iliac crests in 290 patients with primary breast cancer. Interphase cells were enhanced and stained immunocytologically with two antibodies: BM2, which detects tumour-associated glycoprotein TAG 12, which is typically expressed by almost all breast cancer cells, and the anti-cathepsin D antibody. 67 of 149 BM2-positive women (45%) developed metastatic disease (median follow-up time: 69 months). Of these, 15 were cathepsin D-positive (22%). Patients with cathepsin D-positive cells in bone marrow (n = 26; 9%) had a significantly shorter metastasis-free interval (38 months) compared with women who were cathepsin D-negative (64.5 months). The worst prognosis was seen in patients positive for both markers (30.5 months), followed by those who were cathepsin D-negative and BM2-positive (48 months). The detection of cathepsin D on disseminated tumour cells characterises a subgroup of patients with a poorer prognosis who should undergo more aggressive adjuvant systemic therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005965927185
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Metastatic breast cancer: clinical course, prognosis and therapy related to the first site of metastasis (2000)
    Springer
    Breast cancer research and treatment 59 (2000), S. 271-278 
    Details
    ISSN: 1573-7217
    Keywords: bone metastases ; breast cancer ; clinical course ; localization of metastases ; prognosis ; therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Although metastasis is a frequent event in breast cancer patients, insight into the clinical course, prognosis and therapy with respect to the site of the first metastases has been poor and contradictory in former investigations. Follow-up data from 648 patients with metastatic breast cancer were statistically analyzed. Patients with bone metastases at first relapse had better overall survival (median 71 vs. 48 months; p〈0.001) and survival after first metastases (median 24 vs 12 months; p〈0.001) than patients with visceral metastases at first relapse. Bone was the site of first metastasis in 46%, and 71% of patients with metastatic breast cancer developed bone metastases. The localization of the second metastatic site was of prognostic relevance in patients with first visceral metastases, but not in patients with first bone metastases. The presence of osseous metastases correlated significantly with estrogen and progesterone receptor positivity, tumor grading I/II and S-phase fraction 〈5%. The better prognosis of patients with bone metastases is not determined exclusively by hormone receptor status. The disease is significantly more stable in patients with first bone metastases than in those with first visceral metastases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006308619659
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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