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  • 1
    Electronic Resource
    Electronic Resource
    Expression of Staphylococcus saprophyticus surface properties is modulated by composition of the atmosphere (1995)
    Springer
    Medical microbiology and immunology 184 (1995), S. 81-85 
    Details
    ISSN: 1432-1831
    Keywords: Staphylococcus saprophyticus surface-associated protein ; Haemagglutinin ; Protein expression ; Environmental regulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Expression of two major surface proteins of Staphylococcus saprophyticus, the haemagglutinin and the Staphylococcus saprophyticus surface-associated protein (Ssp), requires carefully defined culture conditions. The Ssp is produced when bacteria are grown on agar, whereas expression of the haemagglutinin requires growth in broth. We sought to identify the environmental signals that are responsible for this modulation. Varying the pH, the osmolarity of the growth medium or the temperature did not influence expression of the proteins. In contrast, growth in an anaerobic atmosphere increased haemagglutination titres and fibronectin binding (both mediated by the haemagglutinin) but suppressed production of the Ssp. As the influence of the CO2 level could be excluded, we conclude that expression of these surface proteins is probably modulated by the O2 content of the atmosphere.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00221391
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  • 2
    Electronic Resource
    Electronic Resource
    GyrA sequence-based typing of Legionella (2000)
    Springer
    Medical microbiology and immunology 189 (2000), S. 7-11 
    Details
    ISSN: 1432-1831
    Keywords: Key wordsLegionella ; GyrA ; Typing ; Quinolone resistance-determining region ; Pulsed-field gel electrophoresis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Comparative sequence analysis of a 423-bp segment of the gyrA gene including a region homologous to the quinolone resistance-determining region (QRDR) of other species was evaluated as a novel typing method for Legionella strains. The study was performed with 29 reference strains representing 11 different Legionella species, with various serogroups, and with 13 clinical isolates of L. pneumophila. Pulsed-field gel electrophoresis and serotyping were employed for comparison of the clinical isolates. QRDR sequencing proved to be a highly discriminative tool for typing Legionellae, and permitted identification of species, serogroups and even different strains within serogroup 1. None of the isolates were resistant to quinolones in vitro and this correlated with dissence of mutations in the QRDR region. The data show that comparative sequence analysis of a short fragment of the gyrA gene is a potentially useful tool for typing of Legionella beyond the serogroup level. It is anticipated that mutations of the QRDR may arise in Legionella as a consequence of the introduction of quinolones as the agents of choice for the treatment of infections with this agent in immunocompromised patients. The employment of QRDR-typing maybe helpful in uncovering such mutations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00008255
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  • 3
    Electronic Resource
    Electronic Resource
    The new managerialism in education management: corporatization or organizational learning? (2002)
    Bingley : Emerald
    Journal of educational administration 40 (2002), S. 534-551 
    Details
    ISSN: 0957-8234
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Education
    Notes: During the 1990s, many schools and universities had begun to phase out traditional forms of educational governance and adopted forms and practices used in private and corporate management. Yet, the meaning (and implementation) of these changes is contested. Proponents of the new managerialism in education argue that managerial methods are necessary to respond to the demands of a changed environment with dramatically increased degrees of uncertainty in a knowledge-dependent society. Opponents view the new managerialism in the context of capitalist corporatism penetrating heretofore sacrosanct boundaries of non-market institutions. In this paper, I argue that the ongoing changes in education management are better understood as instances of organizational learning in response to the limits of bureaucratic organization in turbulent environments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/09578230210446027
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  • 4
    Electronic Resource
    Electronic Resource
    From "loose coupling" to "tight management"? Making sense of the changing landscape in management and organization theory (2002)
    Bingley : Emerald
    Journal of educational administration 40 (2002), S. 515-520 
    Details
    ISSN: 0957-8234
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Education
    Notes: This article briefly considers the changes in organizational thinking about schools and colleges as formal organizations over the past 40 years. While there are signs for a "paradigm" shift away from earlier conceptions of "loosely coupled" organizations and even of a growing indifference of organization scholars to the particular problems of managing and organizing education, there are also indications that our ability to organize schools and universities effectively and efficiently is becoming rapidly more important in an increasingly knowledge-dependent society.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/09578230210454992
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  • 5
    Electronic Resource
    Electronic Resource
    Between theory and experience: The dia-logical nature of managerial knowledge - implications for the preparation of education leaders (2003)
    Bingley : Emerald
    Journal of educational administration 41 (2003), S. 455-470 
    Details
    ISSN: 0957-8234
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Education
    Notes: Argues for the need to conceive managerial and administrative knowledge as dia-logical (as opposed to technical) knowledge and explores the implications for the preparation of education leaders. Although there is widespread agreement that knowledge-in-action (know how, intuition, tacit knowledge) is different from technical or propositional knowledge, the preparation of education practitioners continues to be conducted as if the acquisition of technical knowledge was all-important. Given that the university, as an institution, is always likely to favour technical over dialogical knowledge, it is important to demonstrate that the notion of "intuition", "experience" or "tacit knowledge" are anchored in the best traditions of pragmatism, as well as in the current surge of interest in knowledge management.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/09578230310489326
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  • 6
    Electronic Resource
    Electronic Resource
    Cloning of aas, a gene encoding a Staphylococcus saprophyticus surface protein with adhesive and autolytic properties[Parts of t] (1998)
    Oxford BSL : Blackwell Science Ltd, UK
    Molecular microbiology 29 (1998), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: A gene encoding a novel cell wall-associated protein of Staphylococcus saprophyticus that binds fibronectin and to sheep erythrocytes has been cloned and sequenced. The 4392 bp open reading frame codes for an amino acid sequence that is quite similar to the Atl, an autolysin, of Staphylococcus aureus and to the AtlE of S. epidermidis. The two regions of most pronounced homology code for an N-acetyl-muramyl-L-alanine amidase and for an endo-β-N-acetyl-D-glucosaminidase. The cloned protein lysed cells of S. saprophyticus and Micrococcus luteus exogenously. Subcloning localized the enzymatic activities to the regions of high homology and demonstrated that the interposed sequence is responsible for the adhesive activities. Two allelic replacement mutants were constructed that lacked autolytic activity and adhesive properties. The N-terminal portion of the protein contains seven highly conserved, contiguous repeats with no similarity to published sequences. It lacks the motifs typical of Gram-positive surface proteins and shows a different overall organization. This autolysin/adhesin of S. saprophyticus (Aas) appears to represent a new class of staphylococcal adhesins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2958.1998.00983.x
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  • 7
    Electronic Resource
    Electronic Resource
    No Association Between Helicobacter pylori Genotypes and Antibiotic Resistance Phenotypes within Families (2002)
    Oxford, UK : Blackwell Science Ltd
    Helicobacter 7 (2002), S. 0 
    Details
    ISSN: 1523-5378
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background. Triple therapy combining a proton pump inhibitor with two antibiotics, e.g. clarythromycin (CLR), metronidazole (MTZ) or amoxicillin (AMX), represents the standard in Helicobacter pylori eradication regimens. Resistance to antimicrobial agents, particularly MTZ (up to 56% in Western countries) and CLR (up to 15% in southern Europe), is frequently observed and may be associated with treatment failure [1]. Recently, several studies indicated that individual H. pylori colonies from a single anatomic site may not always yield identical genotypes, or the identical patterns of susceptibility to antibiotics [2–5]. Representative for every single patient we analyzed 27 H. pylori antrum isolates for susceptibility to antimicrobial agents in order to test whether identical H. pylori genotypes exhibit a similar pattern of susceptibility to antibiotics.Methods. PCR, RELP, PFGE, antibiotic susceptibility testing.Results. H. pylori genotype and antibiotic susceptibility pattern in families do not segregrate.Conclusion. Molecular typing of H. pylori from family members does not predict antibiotic susceptibility pattern.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1523-5378.2002.00111.x
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  • 8
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    Unknown
    Das Tier als Medium numinoser Begegnung (1976)
    Köln : Periodicals Archive Online (PAO)
    Zeitschrift für Religions- und Geistesgeschichte. 28 (1976) 289 
    Details
    ISSN: 0044-3441
    Topics: History , Philosophy , Theology and Religious Studies
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:6475-1976-028-00-000010
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  • 9
    Electronic Resource
    Electronic Resource
    The hemagglutinin of Staphylococcus saprophyticus binds to a protein receptor on sheep erythrocytes (1997)
    Springer
    Medical microbiology and immunology 186 (1997), S. 37-43 
    Details
    ISSN: 1432-1831
    Keywords: Key words Hemagglutinin ; Adhesion ; Sheep ; Receptor ; Membrane-proteins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Staphylococcus saprophyticus, an important cause of urinary tract infections, produces two major surface proteins, the S. saprophyticus surface-associated protein (Ssp) and the hemagglutinin, which mediates fibronectin binding and also functions as the major adhesin of the organism. The hemagglutinating and fibronectin binding functions probably reside on different parts of the molecule. To identify a receptor on eukaryotic cells, binding and inhibition studies with acidic and neutral glycosphingolipids, carbohydrates, and proteins of sheep erythrocyte membranes were conducted. S. saprophyticus did not bind to any glycosphingolipid and no inhibition was observed when hemagglutination assays were done in the presence of carbohydrates or fibronectin. Neither treatment of erythrocytes with galactose oxidase or neuraminidase and galactose oxidase nor mild periodate oxidation of erythrocytes reduced hemagglutination. However, proteinase-treated erythrocytes were no longer agglutinated. Similarly, untreated erythrocyte membranes inhibited hemagglutination, whereas proteinase-treated membranes did not. In addition, only hemagglutinating strains bound to 60- and 21-kDa sheep erythrocyte membrane proteins on ligand blots, and these proteins inhibited hemagglutination. Our data indicate that, in contrast to many other hemagglutinins, the receptor on sheep erythrocytes for S. saprophyticus is a protein.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004300050044
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  • 10
    Electronic Resource
    Electronic Resource
    [η]-M-Beziehung von PolyoctenamerenHerrn Prof. Dr. Heinrich Hellmann zum 60. Geburtstag gewidmet (1974)
    Weinheim : Wiley-Blackwell
    Angewandte Makromolekulare Chemie 37 (1974), S. 97-103 
    Details
    ISSN: 0003-3146
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Solution properties of polyoctenamers were studied. A relation [η]-M in toluene at 25°C was elucidated. The kθ-value derived from this relation agrees quite well with similar data of polybutadiene, polypentenamer and polyethylene. No evidence was found for the existence of cyclic structures in polyoctenamers.
    Notes: Lösungseigenschaften von Polyoctenameren wurden untersucht. Eine Viskositäts-Molekulargewichts-Beziehung in Toluol bei 25°C wurde ermittelt. Der daraus abgeleitete kθ-Wert stimmt mit den für Polybutadien, und Polyäthylen bekannten Werten überein. Ein Hinweis auf die Existenz von ringförmigen Makromolekülen konnte nicht gefunden werden.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/apmc.1974.050370108
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