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  • 1
    Electronic Resource
    Electronic Resource
    Regenerated cutaneous nerves in human epidermal and subepidermal regions. An electron microscopy study (1984)
    Springer
    Archives of dermatological research 276 (1984), S. 115-122 
    Details
    ISSN: 1432-069X
    Keywords: Cutaneous nerve ; Regeneration ; Adult human skin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To elucidate the regeneration of cutaneous nerves in human skin, biopsy specimens were taken from the regenerated skin of extremities of five adult men with third degree burns that had occurred about 3 weeks previously. Numerous subepidermal nerves could be detected in the newly formed granulaltion tissue, independent of the blood vessels. These nerves were axon-Schwann's cell complexes. Some axons were packed with small clear vesicles 40–60nm in diameter or large dense-cored vesicles 70–100 nm in diameter and large dense bodies. Schwann's cell components showed a relatively abundant cytoplasm and many microfilaments. Intraepidermal nerves were frequently encountered in the interspace between the basal lamina and the cytomembrane of basal keratinocytes in most cases or in the intercellular spaces between basal keratinocytes; however, they were never seen in and beyond spinous layers. They were seen as axon-Schwann's cell complexes or naked axons. In one case a Schwann's cell containing axons migrated into the epidermis. These findings suggest that cutaneous nerves may show hyperregeneration in very early stages of wound healing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00511068
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  • 2
    Electronic Resource
    Electronic Resource
    Scanning electron microscopy of skin surface and the internal structure of corneocyte in normal human skin. An application of the osmium-dimethyl sulfoxide-osmium method (1988)
    Springer
    Archives of dermatological research 280 (1988), S. 293-299 
    Details
    ISSN: 1432-069X
    Keywords: Scanning electron microscopy ; Corneocyte ; Skin structure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A horny layer of normal human skin prepared according to the newly developed osmium-dimethyl sulfoxide-osmium method was examined using scanning electron microscopy. On the skin surface, cytomembranes of the uppermost corneocytes frequently had unilateral, very slightly flat-elevated, zonal areas along the junctions between the corneocytes. The uppermost corneocytes peeled off along the junctions, leaving the remnants of their cell bodies in the junctional areas. In the cracked surface, cytomembranes of the corneocytes protruded from the plane of their cytoplasmic surface. In the lateral junction between the corneocytes, the cytomembranes of the corneocytes were in tight contact with each other, while occasionally the marginal bands had become detached from the cytomembranes. In the vertical connection, cleavages formed between the cytomembranes of the corneocytes. There were thick woollen thread-like structures about 10–30 nm thick in the cytoplasm of the corneocytes. They formed fine irregular meshworks, with their tips projecting digitally: Transmission electron microscopy revealed these structures as most likely being keratin bundles transformed during processing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00440603
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  • 3
    Electronic Resource
    Electronic Resource
    Chondroid syringoma associated with hidrocystoma-like changes. Possible differentiation into eccrine gland. A histologic, immunohistochemical and electron microscopic study (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 16 (1989), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A case of chondroid syringoma associated with hidrocystoma-like changes was investigated by histology, immunohistochemistry and electron microscopy. Chondroid syringoma was histologically compatible with apocrine mixed tumor, and hidrocystoma-like changes did not fulfill diagnostic criteria of either eccrine hidrocystoma or apocrine hidrocystoma. However, epithelial cellular elements composing both chondroid syringoma and hidrocystoma-like changes suggested, immunohistochemically and electron microscopically, differentiation into eccrine gland. The lesions of both had an apparent transition of ductal structures of chondroid syringoma into hidrocystoma-like changes. Therefore, chondroid syringoma and hidrocystoma-like changes in this case may be organized as a peculiar type of cutaneous appendage tumor differentiating toward eccrine gland.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0560.1989.tb00053.x
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  • 4
    Electronic Resource
    Electronic Resource
    A case of secondary cutaneous amyloidosis: epidermal keratinocytes produce amyloid in the cytoplasm (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 17 (1990), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A case of secondary localized cutaneous amyloidosis associated with a seborrheic keratosis is reported. Amyloid was observed both in the stroma and in the tumor. Light and electron microscopy revealed amyloid within the cytoplasm of the tumor cells. This intracytoplasmic amyloid was seen in basaloid cells or in the border areas between basaloid cells and squamous cells, but it was not seen in squamous cells. The amyloid was positive for anti-keratin antibody and contained disulfide bonds. It is suggested that either abnormal keratinization or the degeneration of basaloid cells produced abnormal keratin proteins that formed this amyloid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0560.1990.tb00078.x
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  • 5
    Electronic Resource
    Electronic Resource
    Determination of malonaldehyde precursor in tissues by thiobarbituric acid test
    Amsterdam : Elsevier
    Analytical Biochemistry 86 (1978), S. 271-278 
    Details
    ISSN: 0003-2697
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0003-2697(78)90342-1
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  • 6
    Electronic Resource
    Electronic Resource
    A plan for on-line production and acceleration of radioactive isotope beams by use of electron cyclotron resonance ion source NANOGAN : The 8th international conference on ion sources (2000)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 71 (2000), S. 777-779 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: For the precise low background experiments on β decay and material sciences, we are planning to build a new ISOL-type facility to accelerate various β-radioactive nuclei utilizing the existing 5 MV Van de Graaff accelerator and an RFQ linac. Present status of the designing work is reported. In the present work, optical elements of the 41-m-long beam transport line to connect Van de Graaff accelerator and an RFQ linac were designed. Using two dipole magnets, two electric quadrupole doublets and six electric quadrupole triplets, low energy radioactive nuclear beams can be transported with sufficient efficiency. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1150291
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  • 7
    Electronic Resource
    Electronic Resource
    Sox2 expression in human stomach adenocarcinomas with gastric and gastric-and-intestinal-mixed phenotypes (2005)
    Oxford, UK : Blackwell Science Ltd
    Histopathology 46 (2005), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aims:  Other than ectopic expression of intestinal transcription factors, Cdx1 and Cdx2, the molecular mechanisms underlying gastric and intestinal phenotypes of human stomach adenocarcinomas have yet to be clarified in detail. We have reported that Sox2, an HMG-box gastric transcription factor, is expressed in normal gastric mucosa and down-regulated in intestinal metaplasia.Methods and results:  We analysed mRNA levels of Sox2 and other differentiation markers in 50 surgically resected stomach adenocarcinomas, immunohistochemically classified into gastric (G), gastric-and-intestinal (GI)-mixed, solely intestinal (I), and null (N) types. Sox2 was found to be transcribed in G and GI-mixed type adenocarcinomas in accordance with MUC5AC and MUC6 expression, while Cdx1 and Cdx2 were up-regulated in GI-mixed and I types along with the expression of MUC2 and villin. In the N type, both gastric and intestinal transcription factors were suppressed. Immunohistochemistry confirmed expression of Sox2 in MUC5AC+ lesions and Cdx2 localization together with MUC2. A stomach adenocarcinoma cell line, KATOIII, demonstrated both MUC5AC and Sox2, although MUC5AC mRNA was not detected in the Sox2+ AGS cell line.Conclusions:  Sox2 may play an important role in maintaining a gastric phenotype in stomach cancers as well as in normal tissue, in cooperation with other cofactor(s).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.2005.02170.x
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  • 8
    Electronic Resource
    Electronic Resource
    Thermal injury induces both necrosis and apoptosis in rat skin (1997)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 137 (1997), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1997.tb03805.x
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  • 9
    Electronic Resource
    Electronic Resource
    The value of genotypic analysis in the assessment of cutaneous plasmacytomas (1997)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 137 (1997), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We report a 79-year-old woman with primary cutaneous plasmacytoma in whom polymerase chain reaction (PCR) was used to demonstrate the monoclonality of the tumour. Four years after presentation, further skin lesions occurred and PCR again showed evidence of monoclonality despite the histology being non-specific. The reported frequency of multiple primary cutaneous plasmacytoma is increasing, and the mortality rate of patients with multiple lesions is three times that of those with a solitary lesion. PCR may be a useful technique for assessing such patients at presentation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.1997.18611931.x
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  • 10
    Electronic Resource
    Electronic Resource
    Lymphocytoma cutis induced by cobalt (1997)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 137 (1997), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1997.tb03763.x
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