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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 57 (1935), S. 983-984 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 55 (1933), S. 4384-4391 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Diabetologia 19 (1980), S. 54-57 
    ISSN: 1432-0428
    Keywords: Rat fetus ; B cell differentiation ; pancreatic insulin ; maternal diabetes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fetal pancreatic development was measured in terms of total organ DNA and insulin concentration (ng/μg DNA) in the offspring of rats made mildly diabetic by intraperitoneal streptozotocin injection (60 mg/kg) on the first and second day of life. On day 20 the mean pancreatic insulin concentration of fetuses of diabetic mothers was significantly higher than that of controls (27.8 versus 20.8 ng/μg DNA) but no significant difference was observed on day 18 (4.47 versus 4.68 ng/μg DNA), day 16 (0.64 versus 0.77 ng/μg DNA) or day 14 (0.04 versus 0.03 ng/μg DNA). No significant difference in total pancreatic DNA was observed between test and control animals on day 14, 16, 18 or 20 of gestation. It is concluded that maternal streptozotocin diabetes alters the development of the differentiated fetal B cell (20 days) but has no effect on the protodifferentiated B cell (14 days), or during the period of secondary transition (16–18 days).
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Diabetologia 19 (1980), S. 143-147 
    ISSN: 1432-0428
    Keywords: Rabbit fetus ; insulin ; somatomedin activity ; cartilage growth
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of insulin injection in fetal rabbits on plasma somatomedin activity and cartilage metabolism was investigated. One fetus in each of 12 litters was injected with 1 unit of insulin zinc suspension subcutaneously on day 27 of gestation and a control fetus was injected with the same volume of 0.154 mol/l saline. The litter was delivered by caesarean section on day 29 and each fetus identified. Plasma somatomedin activity was determined by fetal rabbit cartilage bioassay. Costal cartilage from individual fetuses was incubated in medium containing [3H]thymidine or [35S]sulphate as indicators of cell replication and matrix synthesis respectively. Individual values for somatomedin activity or cartilage isotope uptake were ranked within a litter. In each case the rank in the litter of the insulin-injected fetus, but not the saline-injected fetus, was significantly higher than the mean rank of the litter. Insulin did not stimulate cartilage metabolism in vitro.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Diabetologia 13 (1977), S. 637-638 
    ISSN: 1432-0428
    Keywords: Hypoglycin ; insulin secretion ; rabbit pancreas ; glucose ; radioimmunoassay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Hypoglycin A (0.01–1.0 mmol/l) stimulated insulin release from pieces of rabbit pancreas in vitro in the presence or absence of extracellular glucose. The relevance of this finding to the hypoglycaemia of Jamaican vomiting sickness is discussed.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-0428
    Keywords: Rat fetus ; streptozotocin ; insulin ; pancreas ; somatomedin ; growth ; cartilage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A mildly diabetic state was induced in pregnant rats following treatment with streptozotocin the day after mating. On day 21 of gestation, these rats had a lower plasma insulin (55±9 versus 107±23 mU/l for control rats; p〈0.05, mean ±SEM) and a reduced pancreatic area occupied by insulincontaining cells compared with control animals (0.40±0.04 versus 1.03±0.08%; p〈0.001), but hyperglycaemia was not apparent. Fetuses from mildly diabetic animals were longer but not heavier than those from control rats. Plasma somatomedin activity measured by fetal rat cartilage bioassay was higher in fetuses from mildly diabetic rats (1.12±0.07 versus: 0.74±0.05 U/ml for control fetuses; p〈0.001) as was cartilage metabolic activity in basal culture medium (35S sulphate uptake) (1 883±141 versus 1473±104 c.p.m./mg for control rats; p〈0.05), but plasma insulin levels and the pancreatic area occupied by insulin-containing cells did not differ between the two groups of fetuses. Fetal plasma somatomedin activity, measured by fetal cartilage assay, showed a significant positive correlation with both body weight and length. It is concluded that by day 21 of gestation a small body overgrowth had occurred in the fetus of the mildly diabetic rat and this was associated with an increase in plasma somatomedin activity, but not with any abnormality of circulating insulin levels or volume density of B cells in the pancreatic islets.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 141 (1983), S. 46-49 
    ISSN: 1432-1076
    Keywords: Peak expiratory flow rates ; Children ; Greece
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Peak expiratory flow rate (PEFR) and standing height (Ht) were measured in 522 healthy Greek children aged 7–16 years. The regression equation of PEFR on height in centimetres was PEFR=5.34 Ht-380.8. This demonstrated markedly higher values for PEFR in Greek children compared to previously published data from other countries. A sample of 339 British children was examined similarly. The regression equation of PEFR on height in centimetres was PEFR=5.64 Ht-472.5. This was similar to previously published data. No cause for this discrepancy was found after close examination of population sampling, measurement error or calibration error in the Greek study. It is therefore concluded that Greek children appear to have an unexpectedly high PEFR for height.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 146 (1987), S. 113-122 
    ISSN: 1432-1076
    Keywords: Prenatal growth ; Nutrition ; Insulin ; Placental lactogen ; Tissue growth factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The evidence reviewed here shows that the endocrinology of fetal growth is very different from that operating postnatally. Pituitary hormones play little part in stimulating growth of the lean body mass or skeleton although growth hormone (GH) may be involved, in some as yet ill defined way in the ontogeny of the fetal pancreatic islet and insulin secretion. Insulin is important because it stimulates fetal cellular anabolism but acts in a permissive manner: with too little insulin growth is inhibited, with too much growth proceeds at a genetically predetermined rate. Placental lactogen (PL), or other peptides within the GH/PL family, may act as a true growth-promoting hormone in the fetus; it stimulates both cellular metabolism and mitosis. The part played by endocrine control mechanisms in the fetus is set in context by an appreciation of the importance of locally acting tissue growth factors, and in particular the somatomedins. Their part in fetal growth control is intimately bound up with the plane of nutrition experienced by the fetus. It is concluded that the simplest analysis that makes biological sense involves a consideration of hormones, tissue growth factors and nutrition, not hierarchically but as mutually interacting variables.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 140 (1983), S. 135-137 
    ISSN: 1432-1076
    Keywords: Nocardia infection ; Primary abdominal
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A Sudanese girl became desperately ill with liver and kidney abscesses due to Nocardia asteroides. She did not have pulmonary or cutaneous infection. She recovered after surgical drainage of the abscesses and prolonged treatment with intravenous amikacin and high dosage cotrimoxazole and sulphadimidine. After recovery normal neutrophil function, cell-mediated and humoral immunity were demonstrated.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Calcified tissue international 35 (1983), S. 135-144 
    ISSN: 1432-0827
    Keywords: Total body calcium ; Neutron activation analysis ; Femur ; Radius ; Ulna ; Densitometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary In a heterogeneous group of 12 male and 30 female patients, total body calcium (TBCa) was measured by neutron activation analysis, and bone mineral content of the distal femur and six regions of the distal radius and ulna were measured by photon absorptiometry. TBCa was an average of 71 g (9%) lower than normal in the females and 119 g (11%) lower than normal in the males. Of the forearm measurements, those of the radial shaft provided the best estimate of TBCa with a standard error of estimation (SEE) of 88 g (14% of the mean value) for female patients alone, and 113 g (16%) for the whole group. The measurement on the femur provided a better estimate with SEE 80 g (13%) for female patients and 90 g (13%) for the whole group. These SEE are comparable with the variability in TBCa between normal subjects, which has a coefficient of variation of the order of 20% in both sexes. A slightly better estimate of TBCa can be obtained by using a multiple regression equation involving both the femur and radial shaft measurements with a SEE of 74 g (12%) for female patients and 81 g (11%) for the whole group. The correlation between the estimated deficit of TBCa and the estimated deficit of bone mineral from the forearm and the femur has been calculated.
    Type of Medium: Electronic Resource
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