ISSN:
1573-6849
Keywords:
chromosome 12
;
gene mapping
;
12q13–q15
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract The gene loci CDK4, GLI, CHOP and MDM2 have been mapped to the q13–q15 region of chromosome 12. Using fluorescencein situ hybridization onto simultaneously DAPI-banded metaphase chromosomes and interphase nuclei, we have more precisely mapped and ordered these loci, together with a number of Genethon microsatellite markers. GLI and CHOP localize to 12q13.3–14.1, CDK4 to 12q14 and MDM2 to 12q14.3–q15, and the gene order is cen-GLI/CHOP-CDK4-MDM2. The Genethon microsatellites D12S80 and D12S83 flank MDM2.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00713052
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