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  • 1
    Electronic Resource
    Electronic Resource
    EFFECTS OF ISOTONIC SALINE LOADING ON RENAL TUBULAR AND NEUROGENIC DOPAMINE RELEASE IN CONSCIOUS RABBITS (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 22 (1995), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. This study was designed to investigate the effects of isotonic saline loading on renal tubular and neurogenic dopamine (DA) in conscious rabbits.2. Isotonic saline loading did not affect mean arterial pressure, heart rate or renal blood flow but markedly increased urine volume, sodium excretion and DA excretion.3. Renal DA spillover was not affected by venous emptying, while renal noradrenaline (NA) spillover tended to decrease during saline loading. The ratio of % renal DA spillover to % renal NA spillover increased to 2.3 ± 0.6 (P 〈 0.05) 3h after saline loading.4. Isotonic saline loading increased renal tubular DA production but had little effect on neurogenic DA release.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1995.tb02047.x
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  • 2
    Electronic Resource
    Electronic Resource
    ENALAPRILAT RESTORES SENSITIVITY OF BAROREFLEX CONTROL OF RENAL AND TOTAL NORADRENALINE SPILLOVER IN HEART FAILURE RABBIT (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 20 (1993), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The acute effect of an angiotensin converting enzyme inhibitor (ACEI), enalaprilat, on baroreflex-mediated changes in renal and total NA spillover rate in conscious rabbits with doxorubicin-induced cardiomyopathic congestive heart failure (CHF) were investigated under resting conditions and in response to changes in arterial pressure induced by sodium nitroprusside and phenylephrine infusions.2. Six saline-treated (N group) and 11 doxorubicin-treated rabbits (1 mg/kg administered i.v. twice weekly) were studied after 4 and 6 weeks treatment. Five CHF rabbits received saline (C group) and six enalaprilat infusion (ACEI group).3. After 4 weeks of doxorubicin, mean arterial pressure (MAP)-renal noradrenaline (NA) spillover and MAP-total NA spillover curves did not change during enalaprilat infusion.4. After 6 weeks, the C group showed blunted MAP-renal NA spillover and MAP-total NA spillover curves. In the ACEI group, however, both curves returned toward those seen in the N group (slope of MAP-renal NA curve: from 0.27 to 1.80 ng/min per mmHg, MAP-total NA curve: from 1.61 to 3.59 ng/min per mmHg).5. Results of this study indicate that enalaprilat enhances baroreflex control of renal and total NA spillover in rabbits with CHF and further support the view that activation of the renin-angiotensin system contributes significantly to the attenuated baroreflex responses in CHF.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1993.tb01709.x
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  • 3
    Electronic Resource
    Electronic Resource
    A SYMPATHETIC COMPONENT OF BAROREFLEX FUNCTION IN PATIENTS WITH ESSENTIAL HYPERTENSION (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 16 (1989), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 〈list xml:id="l1" style="custom"〉1The baroreflex-mediated changes in plasma norepinephrine (NE) and heart period (RR interval) to phenylephrine (PE)-evoked pressor and nitroprusside (NP)-evoked depressor stimulations were studied in 19 patients with chronic essential hypertension, 12 with borderline hypertension and in 11 age-matched normal controls.2Intravenous infusion of PE at a rate of 0.25-1.0 |ig/kg/min induced dose-related increases in fhean arterial pressure (MAP) and in RR interval and a decrease in plasma NE. Similarly, NP infusion at a rate of 0.1-0.4 ug/kg/min evoked the opposite changes in each variable. The reflex sensitivity was defined as the slope of linear regression between the changes in RR interval and MAP (RR/MAP) and between those in plasma NE (% of the baselines) and MAP (%NE/MAP).3Both RR/MAP and %NE/MAP for pressor and depressor stimulations were reduced below values found in normal subjects, in both chronic and borderline hypertensives.4The values of %NE/MAP was negatively related to the basal plasma NE during falls in blood pressure (r= -0.401, P〈0.05).5The %NE/MAP may be a useful index of the sympathetic component of baro-reflex sensitivity. A decrease in %NE/MAP in hypertensive and borderline hypertensive patients suggests a blunted sensitivity of the sympathetic constrictor reflexes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1989.tb03001.x
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  • 4
    Electronic Resource
    Electronic Resource
    Clinical application of horizontal cross rotatory tomography to air-myelography of cervical spine and its significance in cervical spondylosis (1978)
    Springer
    International orthopaedics 2 (1978), S. 31-38 
    Details
    ISSN: 1432-5195
    Keywords: Spine ; Spondylosis ; Myelography ; Tomography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé La tomographie axiale transverse après myélographie gazeuse de la colonne cervicale a été utilisée en clinique afin de comprendre la pathogénie de la myélopathie dans la spondylarthrite ankylosante. Dans un travail expérimental préliminaire, un modèle du cou a été construit avec «Phantom Mix-DP». Les conditions radiographiques optimales ainsi que la signification de l'opacité aérique ont été étudiées à l'aide de ce modèle. Des myélographies gazeuses normales ont été obtenues et étudiées chez 25 adultes en bonne santé, sans anomalies de la colonne cervicale ni de la moelle et les dimensions des trous de conjugaison ont été mesurées par planimétrie. Des tomographies axiales transverses sur myélographie gazeuse de la colonne cervicale ont été effectuées sur 57 patients atteints d'une myélopathie due à une spondylarthrite ankylosante et à une ossification du ligament longitudinal cervical. Les malades ont été classés en groupes selon les résultats morphologiques et planimétriques et la signification clinique de ces résultats a été étudiée en se référant à la compression de la moelle épinière. Cette méthode est valable en tant que technique complémentaire dans les maladies de la colonne cervicale ainsi que pour l'étude de la moelle cervicale.
    Notes: Summary Horizontal cross rotatory tomography has been used with air myelography of the cervical spine to study the pathogenesis of myelopathy in cervical spondylosis. In an experimental investigation, a model of the neck was made of “Phantom Mix-DP”. The optimum X-ray conditions and the significance of the air shadow were studied by using this model. Normal air-myelographs were obtained and studied in 25 healthy adults free from abnormalities in the cervical spine or cervical cord, and the areas of the spinal canal were measured using the planimeter. Horizontal cross rotatory tomography with airmyelography of cervical spine was performed in 57 cases with myelopathy due to cervical spondylosis and ossification of the longitudinal ligament of the cervical spine. The patients were classified into groups according to morphological findings and the clinical significance of these findings was studied with reference to cord compression. This technique was valuable as a supplementary investigation for diseases of the cervical spine and the cervical cord.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00266000
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  • 5
    Electronic Resource
    Electronic Resource
    Diagnosis of lumbar disc herniation by three-dimensional MRI (1998)
    Springer
    Journal of orthopaedic science 3 (1998), S. 18-26 
    Details
    ISSN: 1436-2023
    Keywords: Key words: Three-dimensional magnetic resonance imaging ; lumbar disc herniation ; radiculopathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: The lumbo-sacral region has anatomical lordosis and two-dimensional magnetic resonance imaging (2D-MRI) cannot therefore show spinal roots including the dorsal root ganglions in one picture. This makes it difficult to present the lateral part of spinal root lesions. We have recently described a new three-dimensional magnetic resonance imaging (3D-MRI) method which allows a stereoscopic view of the spinal cord and spinal nerve roots. In the present study, we evaluated three 3D-MRI techniques, rapid imaging spin echo (RISE) small tip angle gradient echo (STAGE), and short TI inversion recovery (STIR), for detecting disc tissue degeneration, and spinal cord and nerve root compression for identification of nerve roots and detecting signal changes indicative of thickening of the nerve root, and for evaluation of the extent of herniation in 30 patients with lumbar disc herniation. The RISE method was superior for detecting signal changes in disc degeneration, (in 100% of patients) compared with the STAGE method (in 56.1% of patients). All methods poorly identified L4 roots compared with L5 or S1 roots. The STIR method was the best for identifying nerve roots (L4, 62.5%; L5, 87.5%; S1, 91.7%). STAGE and STIR were useful for detecting injuries of the nerve roots. RISE showed disc extrusion better than the other techniques (in 64.7% of patients). The presurgical diagnosis on 3D-MRI agreed with the pathology findings at surgery in 71.4% of STIR, 55.6% of RISE, and 33.3% of STAGE MR images. Our results indicate that 3D-MRI is most useful for the diagnosis of lumbar disc herniation and spinal cord and nerve root compression. The STIR method is best for identifying abnormalities of the spinal cord, roots, and intervertebral discs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007760050017
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  • 6
    Electronic Resource
    Electronic Resource
    Catecholamine synthesizing enzymes in 70 cases of functioning and non-functioning phaeochromocytoma and extra-adrenal paraganglioma (1992)
    Springer
    Virchows Archiv 421 (1992), S. 25-32 
    Details
    ISSN: 1432-2307
    Keywords: Phaeochromocytoma ; Tyrosine hydroxylase ; Aromaticl-amino acid decarboxylase ; Dopamineβ hydroxylase ; Phenylethanolaminen-methyltransferase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Immunohistochemical localization of the catecholamine synthesizing enzymes, tyrosine hydroxylase (TH), aromatic L-amino acid decarboxylase (AADC), dopamine-β-hydroxylase (DBH) and phenylethanolamineN-methyltransferase (PNMT), was investigated in 70 cases of functioning and non-functioning phaeochromocytomas comprising 52 of adrenal and 18 of extra-adrenal origin. Of 59 functioning tumours, 30 were mixed epinephrine and norepinephrine-producing (mixed type) and 29 were norepinephrine-producing tumours. TH, AADC and DBH were detected in all functioning phaeochromocytomas, but PNMT was limited to the mixed-type phaeochromocytomas. Non-functioning phaeochromocytomas were divided into two groups, comprising a complete type, which induced neither elevated plasma catecholamines nor their metabolites in urine, and an incomplete type which exhibited no elevated plasma catecholamines, but showed a slightly high urinary vanillylmandelic acid level. In the non-functioning complete-type tumours, immunoreactive TH was negative, but the incomplete tumours of the adrenal medulla had all four enzymes, and corresponded to a mixed-type phaeochromocytoma. AADC and DBH were present universally in all functioning and non-functioning tumours, including TH-negative tumours. TH is a rate-limiting enzyme of catecholamine biosynthesis and deficiency of TH is an important feature of extraadrenal non-functioning phaeochromocytomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01607135
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