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  • 1
    Electronic Resource
    Electronic Resource
    Abortogenic activity of antiserum to alpha-foetoprotein (1976)
    [s.l.] : Nature Publishing Group
    Nature 259 (1976), S. 222-224 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Approximately 100 pregnant mice (day 9-20 of gestation) of the DB2A, C57BL, or Nya:NYLAR strains were injected intraperitoneally with 0.5-2.0 ml of specific anti-AFP (prepared as described under Table 1), with non-immune rabbit serum (NRS), or with buffered saline. The mice were examined 6, 12, 18 ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/259222a0
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Immunotherapeutic suppression in transplantable solid tumours (1974)
    [s.l.] : Nature Publishing Group
    Nature 250 (1974), S. 50-52 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Amniotic fluid (AF) containing AFP was obtained from C57BL mice as described by Sell5. AFP was isolated from the AF by upward flow gel filtration on Sephadex G-75, followed by preparative polyacrylamide gel (PAAG) column electro-phoresis using a modification of Gussev's method6. A single band could ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/250050a0
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Human alpha – Fetoprotein peptides bind estrogen receptor and estradiol, and suppress breast cancer (2000)
    Springer
    Breast cancer research and treatment 63 (2000), S. 41-52 
    Details
    ISSN: 1573-7217
    Keywords: alpha fetoprotein ; breast cancer ; estradiol ; estrogen receptor ; peptides
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Alpha-fetoprotein (AFP) is a transporter of various serum ligands and regulator of cellular growth during pregnancy. Estrogens modify AFP to exhibit growth suppressive properties. We recently synthesized a peptide (P149) from human AFP that suppresses the growth of mouse uterus and MCF-7 breast cancer cells. Here it is shown that molar excess treatment of native AFP with estradiol-17β (E2) exposes the P149 site on AFP. The anti-estrogenic and anti-tumor activities of AFP-peptides were tested in vivo in the immature mouse uterine assay and mammary tumor (6WI-101)-induced ascites assay, and in vitro in a cytostatic assay using five different human breast tumor cell lines. AFP-peptide P149, and fragments of P149, P149A and P149C but not P149B, suppressed the growth in both in vivo assays. P149 also suppressed the in vitro growth of MCF-7, MDA-MB-231, MDA-MB435 breast cancer cells by more than 75%. P149 and P149A bound the estrogen receptor-α (ER) with low affinities compared to E2 and tamoxifen, while P149B bound 3H-E2 with 105 fold less affinity compared to ER. The recent epidemiologic observation that high AFP levels in young pregnant women reduce their subsequent risk of postmenopausal breast cancer may be related to the growth suppressive property of AFP with the exposed P149 epitope.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006484223325
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    Paper (German National Licenses)
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