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  • 1
    Electronic Resource
    Electronic Resource
    A rubro-olivary pathway I. identification of a descending system for control of the dynamic sensitivity of muscle spindles (1967)
    Springer
    Experimental brain research 3 (1967), S. 372-381 
    Details
    ISSN: 1432-1106
    Keywords: Red nucleus ; Inferior olive ; Muscle spindles ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In cats anesthetized with halothane the influence of central stimulation upon the dynamic sensitivity of muscle spindles in the flexor digitorum longus muscle was studied. One mesencephalic and one medullary region were found which caused an increase in dynamic spindle sensitivity when stimulated electrically. Histological identification of stimulating points showed these regions to be the caudal pole of the red nucleus and the inferior olivary nucleus respectively. Lesions in the olive decreased rubral effects on the spindles, indicating that the red nucleus and the olive are parts of the same system descending to dynamic fusimotor neurones. Further evidence for this point are given in a following paper (APPELBERG 1967).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00237562
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    BODY WATER CHANGES IN RELATION TO NUTRITION OF PREMATURE INFANTS (1963)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 110 (1963), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1963.tb15803.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    MANAGEMENT BY OBJECTIVES IN PERSPECTIVE (1972)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of management studies 9 (1972), S. 0 
    Details
    ISSN: 1467-6486
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Economics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1467-6486.1972.tb00541.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    A quantitative analysis of the microglial cell reaction in central primary sensory projection territories following peripheral nerve injury in the adult rat (1983)
    Springer
    Experimental brain research 96 (1983), S. 19-27 
    Details
    ISSN: 1432-1106
    Keywords: Dorsal column nuclei ; Gracile nucleus ; Primary sensory neuron ; Dorsal horn ; Glia ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The time course of the microglial cell reaction in central nervous system primary sensory projection territories has been examined following peripheral nerve injury in the adult rat using qualitative and quantitative analysis of immunoreactivity with the monoclonal antibody OX-42, which recognises the complement receptor CR3. The regions examined included the gracile nucleus, the column of Clarke and the spinal cord dorsal horn (superficial and deep laminae separately) after unilateral sciatic nerve transection, and the spinal trigeminal nucleus following unilateral infraorbital nerve transection. In all territories examined a qualitative increase in OX-42 immunoreactivity was observed 24 h postlesion. Further, quantitative analysis revealed an exponential development of the OX-42 immunoreactivity, with a peak at one week postlesion, thereafter showing a slow exponential decline. Our results show that the signal (or signals) that induces the microglial cell response in primary sensory projection territories is rapid in comparison to previously described central degenerative changes following peripheral nerve lesions (transganglionic degeneration). These findings are compatible with the hypothesis that activated microglia play a pathogenetic role in the development of transganglionic degeneration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00230435
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Changes in microglial cell numbers in the spinal cord dorsal horn following brachial plexus transection in the adult rat (1988)
    Springer
    Experimental brain research 73 (1988), S. 61-68 
    Details
    ISSN: 1432-1106
    Keywords: Microglia ; Dorsal horn ; Nerve lesion ; Light microscopy ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of peripheral nerve transection on the size of the microglial cell population in cytoarchitecturally distinct regions of the spinal cord dorsal horn of rats was evaluated at selected intervals 2 through 35 days after unilateral brachial plexotomy. The identification of cells was verified by electron microscopic examination of a representative random sample of cells included in the counts. Microglial cell numbers were increased in laminae I, II as well as the arbitrarily defined deeper laminae 3.5 days after surgery. Although microglial cell numbers in laminae I were within normal range 35 days after axotomy, those of the more ventrally located laminae remained significantly greater than control values for the duration of the experimental period. These findings demonstrate that: 1) microglial cell proliferation in the dorsal horn is an early event in the central changes that are attendant to peripheral nerve injury 2) the time course of the response varies in cytoarchitecturally different regions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00279661
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  • 6
    Electronic Resource
    Electronic Resource
    Transganglionic transport of the lectin Soybean agglutinin (Glycine max) following injection into the sciatic nerve of the adult rat (1998)
    Springer
    Journal of neurocytology 27 (1998), S. 233-245 
    Details
    ISSN: 1573-7381
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The lectin soybean agglutinin (SBA) from Glycine max binds to small-sized dorsal root ganglion cells and their central terminals in the superficial dorsal horn of the spinal cord. Here we investigated the ability of SBA and SBA conjugated to horseradish peroxidase(SBA-HRP) to trace thin calibre afferents into the spinal cord from a peripheral nerve. Following injection into the sciatic nerve, labelled cells in the dorsal root ganglion were predominantly small-sized but some medium-sized cells were also labelled. Colocalisation studies of transported SBA with various neuronal markers showed that all neurons that transported SBA-HRP showed SBA binding, indicating high uptake specificity for the conjugate. 15% were immunoreactive for RT97 indicating that some axons were myelinated, and 54% also expressed binding sites for isolectin B4 from Griffonia simplicifolia, a selective marker for a subpopulation of unmyelinated afferents. With regard to neurotransmitter content, 43% of the SBA cells contained calcitonin gene-related peptide, 33% contained substance P and 2.5% somatostatin. In addition, 3% contained carbonic anhydrase. Centrally, injection of SBA in the sciatic nerve resulted in labelled terminals in somatotopically appropriate regions of laminae I–II of the dorsal horn, and in the gracile nucleus. A few neurons in the dorsal horn were labelled indicating that some transneuronal transport of SBA had occurred. The results show that SBA can be used as a transganglionic tracer to label fine calibre primary afferents that project to laminae I–II of the spinal cord and the gracile nucleus. It appears to label more afferents than isolectin B4, including also a subpopulation of myelinated afferents.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006980814321
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    A system for manually or automatically controlled gustatory stimulation (1971)
    Springer
    Medical & biological engineering & computing 9 (1971), S. 715-717 
    Details
    ISSN: 1741-0444
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02474655
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    Paper (German National Licenses)
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