ISSN:
1573-8221
Keywords:
hypovolemic hypotension
;
postresuscitation period
;
infusion of dextran
;
RNA
;
proteins
;
acid phosphatase in the cerebral cortex
;
cerebellar Purkinje cells
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Infusions of dextran (10 mg/kg) during the 10 days of the postresuscitation period after hypovolemic hypotension lasting 4 h restored the normal concentrations of total RNA and of the rapidly moving protein fractions corresponding to prealbumins, albumins, postalbumins, ceruloplasmin, transferrin, and α-globulins. However, the high-molecular-weight protein fractions (β- and γ-globulins) remained considerably altered: The concentration of β-globulins was doubled whereas that of γ-globulins was reduced by 41%. The relative acid phosphatase activity increased in the postmitochondrial supernatant by 53%; an increase in acid phosphatase activity was found in the neurons, glia, and vascular endothelium. The number of Purkinje cells in the cerebellar cortex in the experimental series did not differ significantly from the control. The results emphasized the importance of using prolonged dextran influsions in the program of resuscitation measures for the treatment of patients with hypovolemic states.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00801810
Permalink